Discovery analytical consulting 070617

Company Profile: Discovery Analytical Consulting

1. Mark Portsmouth Background Applied Chemistry BSc., Brunel University, 1982-6 3x internships at British Gas Research, Porton Down Chemical Defence Establishment and Metropolitan Police Forensic Science Laboratory Fisons Pharmaceuticals/Astra/AstraZeneca Charnwood, 1986-1999 Bioanalysis Immunoassay HPLC-UV/Fluorescence/ECD Online SPE (AASP and column switching) GLP Medicinal Chemistry Support Introduced Open Access LC/MS, chiral screening, SFC, CE Combinatorial Chemistry analysis and purification CombiPure , 1999-2006 Chemical Library Services High Throughput QC of compound collections High Throughput purification

2. CombiPure 4 column LCMS purification system

3. Background (continued) Galapagos NV, Mechelen, Belgium, 2006-2007 Med Chem support: analysis and purification ADME Takeda Cambridge, 2007-2016 Compound Management Med Chem Support Phys Chem ADME Discovery Formulation Discovery Bioanalysis

4. HolyGrail Software

5. Formed in December 2016 Support to Pharma, Biotech and CROs Consultancy Analytical Chemistry External Study Management Applications Development Training Discovery Workflows Compound Management Automated Data Management Technology Partnerships

6. Key skills Experience in building Analytical Teams from scratch, including development of the necessary infra-structure and ongoing management of these teams to deliver key products and services essential to the successful execution of projects Expertise applied to many aspects of Drug Discovery including supporting key functions such as Medicinal Chemistry, physico-chemical measurement, ADME screening, Bioanalysis and Compound Management

7. Consul tancy Analytical Chemistry Operational reviews Development of analytical strategy, staff resources and capital investment planning Support for synthetic chemistry Advice on all aspects of LC/MS, compound purification, SFC and chiral analysis/purification Compound QC and CofA Physical Chemistry assays Solubility Stability Lipophilicity Discovery Formulation Screening In vitro ADME assays PAMPA Microsomal stability CYP inhibition PPB Metabolite ID Compound Management Strategies, systems and resources for efficient storage, tracking and retrieval of solid and solution compound collections including: Workflow processes from synthesis to assay designed to drive down screening cycle times Advice on appropriate automation strategies and instrumentation Bespoke Compound Management software with features including: Comprehensive sample tracking Assay request system Status tracking Integration with QC data Integration with Analytical systems (e.g. for QC or ADME sample lists)

8. Applications Effective separations developed for clients without the required expertise in house or to mitigate capacity/resource shortage working with in-house experts Undertaking projects at the customer site will negate the need for a subsequent method transfer step Alternatively, laboratory work can be carried out at a fully qualified CRO facility Training In collaboration with a well-established training provider High-quality, affordable, instrument-independent training courses to boost your knowledge, confidence and results in all aspects of LC/MS Training is provided for all levels of experience Approved by the Royal Society of Chemistry for purposes of Continuing Professional Development

9. Strategic Collaborations