drug book.docx

Drugs of pediatric nursing

1. DRUG BOOK

SIGNATURE OF SUBJECT COORDINATOR SIGNATURE OF EXTERNAL

SIGNATURE OF INTERNAL

2. INDEX

3. SR.NO
NAME OR
CLASSIFICATIONS
NAME OF THE DUG

1
ANALGESICS AND
ANESTHETICS
 ACETAMINOHEN
 ASPIRIN
 FENTANYL
 IBUPROFEN
 KETAMINE
 MIDAZOLAM
 PROPOFOL

2
ANTICONVULSANTS
 PHENYTOIN
 PHENO BARBITOL
 SODIUM VALPROATE
 CARBOMAZEPINE

3
ANTI COAGULANTS
 HEPARIN
 WARFARIN

4. 4
ANTIHYPERTENSIVE
 ATENDOL
 PROPRANOLAL
 NEFEDIPINE
 VERAPAMIL

5
DIURETICS
 ACETAZOLAMIDE
 FRUZEMIDE
 MANNITOL
 SPIRANOLACTONE

6
VASODILATORS
 SODIUM NITROPRUSSIDE
 HYDRALAZINE

7
ANTI TUBERCULOSIS DRUGS
 ISONIAZID
 PYRAZINAMIDE
 RIFAMPICIN
 ERYTHROMYCIN

5. 8

ANTI LEPROSY DRUGS
 DAPSON
9


BROCHO DILATORS
 SALBUTAMOL
 ATROPINE SULPHATE
 TERBUTALINE

10

ANTI MALARIAL DRUGS
 CHLOROQUININE PHOSPHATE
 PRIMAQUININE PHOSPHATE




11


ANTIVIRALS
 ACYLOVIR
 RIBOVIRIN
 ZIDOVUDINE

12



CARDIOTONICS
 DGOXIN

6. 13

ANTI BIOTICS
 AMPICILLIN
 PENCILLIN
 TETRACYCLIN HYDROCHLORIDE
 CEFOTAXIM

14

ANTI RETROVIRALS
 INOINAVIR SULPHATE
 ZINDOVUDINE

15

ANTI NEOPLASTIC DRUGS
 CYCLO PHOSPHAMIDE
 VINCRISTINE SULPHATE

7. ANALAGESICS
&
ANESTHETICS

8. SL
NO.
NAME
OF
DRUG
TRADE
NAME
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAINDI
RATION
SIDE
EFFECT
NURSING
RESPONSI
BILITIES
1













ACET
AMIN
OPHE
N
AASE
AEGI
NA
ORA
L
300M
g
 It exhibits
analysis
action by
peripheral
blockage of
pain
impulse
generation
 It produces
antipyretics
effect by
inhibiting
the
hypothalam
ic heart
regulation
center.
 Mild,
moderate
pain
 Post
impyrexi
a
 Rheumat
ic fever
 Hypersensiti
vity









 Nausea
 Vomiting
 Allergic
reaction
 Skin
rashes
 Diarrhea
 Ulceration
 Perforatio
n
 Hemaehag
e
 Neurosis
 Aplastic
anemia
 Check
for any
C.I
 Check
for any
adverse
reaction.
 Follow
the
principle
s of drug
administr
ation.

9. 2



aspirin







Arced


Oral


3-25
mg
80-
100-
mg/kg

 It inhibits
analgesic
action by
antipyretic
action
 A non-
steroidal
salicylate
that inhibits
prosta
glandins
synthesis
acts on the
hypothalam
us heart
regulating
center.
 A substance
that
stimulate
platelet
aggregates.
 It reduces
inflammatio
n, pain,
decreases
fever.

 Analgesia
 Fever
 MI
 Stroke
 Ischemic
attack
 Kawasaki
disease

 Hypersensitivi
ty
 Bleeding
disorders
 Chicken ox
 GI bleeding o
ulceration
 Hepatic
impairment
 Allergy
 Pregnancy
 lactation

 GI distress
 Allergic
reaction
 Bronchospa
sm
 Pursuits
 Urticaria
 Headache
 Tinnitus
 Difficulty in
hearing
 Lethargy
 Confusion
 Drowsiness’

 Use liquid
form for
children &
patient who
are
difficulty in
swallowing
 In children
don’t
exceeds
five dos in
24hrs
 Check vital
signs
 Chick for
any rashes

10. SL
NO.
NAME
OF
DRUG
TRAD
E
NAME
ROUTE DOSE MODE OF
ACTION
INDICA
TION
CONTRAIND
IRATION
SIDE
EFFECT
NURSING
RESPONSI
BILITIES
3



IBUPR
OFEN
-
8-12mg
600-8—
mg







0.4-
0.6gm
Iv









Oral









 It Is a synthetic
compound
having
analgesic &
mid anti-
inflammatory
effect







 Fever
 pain
 a cute peptic
ulcer
 gastric
irritation
 dyspnea
 GI bleeding
 jaundice
 check for
side
effects

11. SL
NO.
NAME
OF
DRUG
TRAD
E
NAME
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATIO
N
SIDE
EFFECT
NURSING
RESPONSI
BILITIES
4



FENT
ANYL
fend
cap
O IV 0.5-
3mg/kg

0.5-
1mg/kg
 it inhibits
prostaglandi
n synthesis






 pain
 anesthesia
 hypersensit
ivity
 dyspnea
 peptic ulcer
 rhinitis
 nausea
 vomiting
 check for
any side
effect &
adverse
reaction
 assess vital
signs
regularly

12. SL
NO.
NAME
OF
DRUG
TRAD
E
NAME
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATIO
N
SIDE
EFFECT
NURSING
RESPONSI
BILITIES
5
PROP
OFOL





- IV 1-
2mgl/kg
It Is an liquid
used as 1%
emulsion. It is
used for i.v
indication &
short duration
anesthesia.
 Sedation
 ECT
 hypersensit
ivity
 nausea
 vomiting
 pain
 headache
 involuntary
muscle
contraction







 check for
any side
effect
 monitor
vital signs

13. ANTI CONVULSANT

14. SL
NO.
NAME
OF
DRUG
TRAD
E
NAME
ROU
TE
DOSE MODE OF
ACTION
INDICAT
ION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSI
BILITIES
1 PHEN
YTOIN
EPTOI
N
Oral 5
mg/kg
 May stabilize
neuronal and
limit seizure
activity either
by increasing
influx of ion
across the cell
membrane is to
monitor cortex
of nerve
impulse
 Tonic
clone
seizure
 Static
epilepti
cs
 Hypersensiti
vity
 Hepatic
dysfunctio
n
 Hypotension
 Respiratory
depression
 Ataxia
 Diplopia
 Vomiting
 Constipation
 Toxichepatit
es









 don’t give
IM unless
dosage
adjustment
 Divided
dose give
with or
after meal.
 Don’t stop
drug
suddenly
 Monitor
drug level.

15. SL
NO.
NAME
OF
DRUG
TRAD
E
NAME
ROUTE DOSE MODE OF
ACTION
INDICAT
ION
CONTRAIND
IRATION
SIDE
EFFECT
NURSING
RESPONSI
BILITIES
2 Sodium
valproa
te
- Oral/IV 10-15
mg/kg
Unknown
facilitated the
effects to
inhibit neuron
transmitter
GABA

 Sample
complex
seizure
 Mixed
seizure
type
 Hypersen
situity
 Hepatic
disease
 Children
younger
than
10years
 Urea cycle
disorders
 Dizziness
 Headache
 Insomnia
 Chest pain
 Hypertensio
n
 Blurred
vision
 Abdominal
pain
 Anorexia
 Diarrhea
 Alopecia


 Obtain
lives
function
test
 Monitor
drug level
 Tell patient
to take
drug c
food/milk
to reduce
and verse
GJ effect.

16. SL
NO.
NAME
OF
DRUG
TRA
DE
NAM
E
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAIND
IRATION
SIDE
EFFECT
NURSING
RESPONSI
BILITIES

3
Diaz
epam
- IV/IM
oral
0.12-
0.8
mg/kg/
day

0.04-
0.3
mg/kg
 A
benzodiazepin
e that
depresses all
levels of the
CNS by
enhancing the
action of
gamma amino
butyric acid, a
major
inhibitory
neurotransmitt
er in the brain
 It produces
anxiolytic
effect, elevates
the seizure
threshold



 Cough
 Anxiety
 Skeletal
muscle
relaxation
 Preanesthe
sia
 Alcohol
arthdeval
 Status
epileptics
 Hypersensitiv
ity
 Angle closure
glaucoma
 Coma
 CNS
depression
 Respiratory
depression
 Sever
uncontrolled
pain
 Pain IM
injection
 Somnolenc
e
 Fatigue
 Ataxia
 Slurred
speech
 Headache
 Constipatio
n
 Nausea
 Blurred
vision
 When the
patient
have
sudden
change of
position
can cause
of zziness
 In street the
patient to
avoid
alcohol
while
taking
diazepam
 Monitor
vital signs.

17. ANTIBIOTICS

18. SL
NO
.
NAME
OF
DRUG
TR
AD
E
NA
ME
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAIND
IRATION
SIDE
EFFECT
NURSING
RESPONSI
BILITIES
1 AMPICI
LLIN













- ORAL
/IV
25-
30mg/k
g
 Inhibit cell-
wall synthesis
during bacterial
multiplication.
 UTI
 G1
infection
 Skin
infection
 Hypersensitiv
ity
 Seizure
 Lethargy
 Vomiting
 Diarrhea
 Nausea
 Anaxity
 Confusion
 Before
giving
drug ask
Pt about
degree of
reaction to
penicillin
 Monitor
Na
+
level

19. SL
NO
.
NAME
OF
DRUG
TR
AD
E
NA
ME
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
2
Penicil
lin
- IV/1m
l oral
500mg  It is bind to
the bacterial
cell wall
synthesis.
 The protects
the penicillin
from
enzymatic
degradation.
 Respirator
y
infection
 UTI
 Meningoc
occal
 infection
 hypersensiti
vity
 seizure
 diarrhea
 nausea
 vomiting
 headache
 oral or
vaginal
candidiasis
 anemia
 monitor the
patients
pulse & B.P
 notify the
vomiting or
diarrhea
 monitor
respiratory
rate& any
rashes
 Cheek for
any side
effect.

20. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAIND
IRATION
SIDE
EFFECT
NURSING
RESPONSI
BILITIES
3 AMIKA
CIN
Amik
in
IV/IM 250 mg
for
12hrs






 It is an
aminoglycoside
antibiotic that
irreversibly
binds to protein
or bacterial
ribosomes.
 Interferes
protein
synthesis of
susceptible
microorganism
 Typhoid
 Bronchitis
 UTI
 Hypersensitiv
ity
 Pain in
duration
 Thromboph
lebitis
 Difficulty
in
breathing
 Drowsiness
 Weakness
 Monitor
patient for
swelling
 Monitor
respiratory
rate.
 Monitor
urine
output
 Monitor the
patient
pulse &
B.P


21. SL
NO
.
NAME
OF
DRUG
TR
AD
E
NA
ME
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAIND
IRATION
SIDE
EFFECT
NURSING
RESPONSI
BILITIES
4 TETRAC
YCLIC
HYDRO
CHLOID
E
- Oral 25-
30mg/k
g
 May exert
bacteriostatic
effect by
binding to
protein or
bacterial
ribosomes.
 They inhibit
protein
synthesis.
 Grana
positive
infections
 Rectal
infection n
 Urethral &
endo-
cervical
infection
 Soretheoat
 Glossites
 Diarrhea
 Hypersensitiv
ity
 Nausea
 Vomiting
 Skin rashes

 Obtain
specimen
for culture
&
sensitivity.
 Check
patient
tongue for
infection
 Check for
any side
effect

22. ANTI COAGULANTS

23. SL
NO
.
NAME
OF
DRUG
TR
AD
E
NA
ME
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAIND
IRATION
SIDE
EFFECT
NURSING
RESPONSI
BILITIES
1 HEARIN













- IV 25-
50units
/kg hr
 Accelerator
reaction of
anti-thrombin
complex and
deactivates
thrombin
preventing of
fibrinogen to
fibrin.
 Pulmonary
embolism
 Deseirited
intravascu
lar
coagulati
on.
 Hypersensitiv
ity
 Active
bleeding
 Ascorbic acid
deficiency
 Fever
 Rhinitis
 Irritation
 Peuritis
 Cut Icaria
 Dew blood
to
establishes
baseline
coagulatio
n before
therapy .
 Check
vital

24. SL
NO
.
NAME
OF
DRUG
TR
AD
E
NA
ME
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAIND
IRATION
SIDE
EFFECT
NURSING
RESPONSI
BILITIES
2 WARFA
RIN




















   

25. ANTI-HYPERTENSIVE

26. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
1 Epineph
rine




















- 1m, sc
IV
0.2-
0.5 ml
0.25m
g
 It has stimulant
action on
predominant B
receptor
 It dilates the
blood vessels of
the skeletal
muscle on
account of
predocinderent
of B2 receptor.
 It increases
heart rate &
myocardial
contractility.
 Anaphylac
tic shock
 Bronchial
asthma
 Cardiac
resusutati
on
 Open
angle
gleeman
 Angoneur
otic
edema of
larynx
 Vertigo
 hypotensio
n
 Hypotension
 Palpation
 Angina
 Nausea
 Headache
 Vomiting
 Sweating

 Use
extrence
caution in
alkylate &
preparing
doses
 Any solution
of adrenaline
that is teen to
panic should
not be given.
 Bp should be
cheeked
energy
15minuts.

27. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
2 Propran
olol
- Oral 0.5-
1mg/k
g/day
 An anti-
hypertensive,
antianginal,
antiarrhythmic, &
ant migraine
agent that blocks
beta1,beta2,
adrenergic
receptors.
 It decreases
oxygen
requirements.
 It slows Av
conduction.
 Therapeutic
effect: decreases
cardiac out put

 Angina
 Arrhythmi
c
 Hypertrop
hy sub
aortic
stenosis.
 Migraine
headache
 MI
 Essential
tremors
 Asthenia
 Beady
card
 Cardiogen
ic shock
 Raynaud
& syndrome
 CHF
 Pregnancy
 Lactation
 Diminished
sexual
ability
 Drowsiness
 Difficulty
sleeping
 Unusual
fatigue
 Beady
cardiac
 Depression
 Diarrhea
 Anxiety
 Pruritus
 Always
cheek patents
apical pulse
before giving
drug.
 Pulse rate
occurs a rolel
drug & notify
pees cubes
incredibly
 Give drug
consistently
meals foods.
May increase
absorption of
propranolol

28. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
3 AMLO
DIPINE
- oral 5-
10mg
 It has antianginal
antihypertensive
actor
 A calcium
channel blockers
that inhibits ca
moucment across
cardiac
&vascular
smooth cell
membrane.
 Therapeutic
effect decreases
peripheral
vascular
resistance & BP
by vasodilation.

 Hypertensi
on
 Angina
 Renal
inepairien
t
 Hyper
sensitivity
 Severe
hypotension
 Aortic
stenosis
 Heart
failure
 Severe
hepatic
diseases
 Peripheral
edema
 Headache
 Flushing
 Dizziness
 Palpitation
 Nausea
 Fatigue
 Chest pain
 Beady cardia
 Orthostatic
hypotension
 Tel the
patient to take
nitroglycerine
for acute
angina
symptoms.
 Notify cline
of irregular
heartbeat,
shortness of
breath,
shortness of
breath ,
swelling of
feet, hand etc.
 Monitor BP
continuously.

29. SL
NO
.
NAME
OF
DRUG
TRAD
E
NAME
ROU
TE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
4 HYDR
ALAZI
NE






- Oral/
IV
0.75-
1mg/k
g/day
 An anti-
hypertensive
direct
vasodilating
effects on
arterials.
 Therapeutic
effect: decreases
BP &
resistance.
 Hypertensi
on
 Failure of
heart
 Hypersens
itivity
 Coronary
artery
disease
 CNA
 Renal
caiemant
 Headache
 Palpitation
 Tachycardi
a
 GI
disturbances
 Nausea
 Vomiting
 Peripheral
ederea
 Dizziness
 Nasal
congestion
 Flushed
face
 CBC, left
cell
purparation
& ANA litxe
diter
mination
should be
performed
before
surgery
 Advise
precaution
from
orthostatic
hypotension.
 For IV use
monitor BP
every
5minutes

30. DIURETICS

31. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
1 FUOSE
MIDE
- Oral/
IV/
IM
1-
6mg/kg
day in
6-12 hr

1-2
mg/kg
(IV,IM)




 Aldop duretic
that enhances
excretion of
sodium chloride
& potassium by
direct action at
the ascending
liner of the loop
of Henley
 It produces
decrees & lower
BP
 Edema
 Hypertensi
on
 Anuria
 Hepatic
coma
 Sever
electrolyte
depletion
 Pregnancy
 lactation
 increased
urinary
frequency
 nausea
 dyspepsia
 abdominal
camps
 diarrhea
 constipation
 electrolyte
disturbance
 dizziness
 to prevent
nocturia give
PO&IM
preparation on
the morning
 monitor
fluid intake &
output
electrolytes,
BUN & co2
level
frequency
 watch for s/s
of
hypokalemia
 monitor
glucose level
in DM patient

32. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
2 SPIRON
OLACT
ONE

-









PO 1.5-3.3
mg/kg/d
ay in 1-
2
divided
doses
 an potassium
sparing durative
that intefeve
sodium
reabsorption by
competitively
inhibiting the
action of
aldosterone in
the distal tubule,
this promoting
Na & H2o
excretive &
 it produce
diuresis lower
BP
 edema
 hypertensi
on
 hirsutine
 mypolcale
nier
 primacy
aldostero
ne
 acute renal
insufficienc
y
 anuria
 BUN &
serum
creatin level
increase
 Hyperkale
mia
 Pregnancy
 Lactation
 Hypertension
 dehydration
 nausea
 lethargy
 dyspepsia
 abdominal
camps
 diarrhea
 constipation
 confusion
 Assess the
patent
actually
 Monitor vital
signs
 Cheek for
any rashes
 Cheek for
abdominal
discomfort
 Give the
drug meals
to enhance
the
absorption
 Instruct the
patient to
report mental
confusion

33. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
3 TRIAM
TEREN
E
- Oral 2-4
mg/kg/d
ay in
single
dose
 A potassium
sparing
directive that
inhibits sodium,
potassium
ATPase
 It increases
odium &
decreases
potassium
excretion
 It produces
decreases &
lowers BP
 Edema
 Hypertensi
on
 Hyperkale
mia
 Renal
disease
 Hepatic
disease
 Pregnancy
 lactation
 fatigue
 nausea
 diarrhea
 abdominal
pain
 leg cramps
 headache
 anorexia
 rash
 dizziness
 ECG
changes
 Assess the
patient
actually
 Monitor vital
signs
 Cheek for
any rashes
 Monitor
ECG
 Monitor
BUN &
creatin
level
 Cheek for
fluid
electrolyte
imbalance

34. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
4 XIPAMI
DE
- Oral 10-
20mg
 It is peniacysite
of action is the
cortical segment
of early distal
tubes.
 If inhibit
sodium
reabsorption,
choice & water
are retained in
the tubule
secondly
 Relaxant effect
on arterioles &
elevation of
blood.
 Edema
 Hepatic
crepauien
t
 Renal
crepavierien
t
 Acute
electrolyte
unbalance
 Cirrhosis
of lives
 Weakness
 Fatigue
 Muscle camp
 GI
disturbance
 Hearing loss
 Monitor vital
signs
 Monitor
patient for
allergic
reaction
 Monitor to
chart
 Provide right
dosage at
right time.

35. VASODILATOR

36. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
1 SODIUM
NITROP
RUSSID
E
- IV/
oral
2.5-10
mg/kg
 A potent
vasodilation
used to treat
energy
hypertension
condition
 It acts directly
on arterial &
venous smooth
muscle
 Decreases
peripheral
vascular
resistance .
 Improves
cardiac outputs
 BP in
hypertoni
c crisis
 Controlled
hypertens
ion in
surgical
procedure
 Acute
CHF
 Hypersens
itivity
 Compensa
tory HTN
 Increased
ICP
 Fleshing of
skin
 Increased
intracranial
pressure
 Rash
 Pain &
redness in
infection
site.
 Monitor the
vital for
every ½
hourly
 Monitor
cardiac
output
 Cheek the
patient
infection site
for any
 Pain redness
are present
or not

37. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
2 HYDRA
LAZINE
- Oral 0.75-1
mg
/kg/day
 An anti-
hypertensive
direct vaso
dilating effects
on bacterial
 Therapeutic
effect decreases
BP and systemic
resistance
 Severe
hypertens
ion
 Angina
 Coronary
artery
disease
 leepus
erythematou
s
 headache
 palpitation
 tachycardia
 nausea
 vomiting
 parenthesis
 fluid
cetertion
 peripheral
edema
 Dizziness
 Flushed face
 Nasal
congestion
 Advise the
patient to
take the drug
meals
 Notify
clinical of
any
unrespects
prolonged
general
tiredness or
fever muscle
or join
aching or
chest pain
 Cheek the
stools
 Advise
precaution
for
orthostatic
hypotension

38. ANTI LEPROSY
DRUGS

39. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
1 DAPSO
NE
- Oral
1m
100mg
0.5ml/
0.2ml
 Bacteriostatic
activity
 It acts by
inhibiting the
de-noro
synthesis of
folic acid by
M.cepeai
 The action is
antagonist by
Para
aminodizolic
acid
 Anti
lepeotic
uses
 Dermatitis

 Hypersens
itivity
 Infant
younger
than
2months
 Hemolytic
anemia
 lever &
kidney
damage
 allergies
reaction
 nausea
 jaundice
 vomiting
 before
administrati
ng the drug
ask the
patient for
any allergic
reaction to
drug
 monitor 1/0
chart
 cheek for
any side
effects

40. ANTI-MALARIAL
DRUGS

41. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
1 CHLOR
OQUINE
PHOSPH
ATE
ARAL
EN
Oral 10mg/
kg
 it is a 4 amino
quinolone
derivative
 it has a
suppressive
effect like
quinine
 it acts by
inhibiting the
incorporation
of phosphate
into RNA &
DNA of
plasmodia’s.
 Acute
malaria
 Extra
intestinal a
moebiasis
 Giardiasis
 Taeneasis
 Arthritis
 Hypersens
itivity
 Skin rashes
 Bleaching of
scalp, nose,
eye lashes
 Visual
distributes
 Blurred
vision
 Diplopia
 Psychotic
episodes
 Abdominal
cramps
 Anemia
 Monitor
complete
blood count
 Ensure that
periodic
visual or
ophthalmic
examination
are
performed
 Monitor
lever
function test.
 Check for
any side
effect
 Check vital
signs

42. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
2 DRIM
AQUIN
EPHOS
PHAT
E

-














Oral 3mg/da
y
 It belongs to
the group of 8
aminoquinolines
 If acts on the
exocrytheocytes
cycle & on
ganeeto cycle
 Sonce of the
ganutocyteace
destroyed
 The remaining
cannot mature
in the mosquito
 Malaria  A granule
cytosols
 Rheumatoi
d arthritis
 Nausea
 Vomiting
 Epigastric
disteriess
 Leukopenia
 Anemia
 Guie the
drug by
follow 6
dights
 Cause the
drug after
meals.
 Obtain
frequent
blood studies
 Cheek vital
signs
 Cheek for
any side
effect

43. ANTI – T.B
DRUGS

44. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATI
ON
CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
1 Pyrazina
mide
- Oral 20-30
mg/kg
body wt
is 3-4
divided
closed
max of
3 gm
daily
 It is the
pyrozine
analogue of
nuotinnude
 When the drug
is used alone the
diseases is
initially
contracted but
soon relapses
because
microorganisms
rapidly resistant
 When it is
administered de
multineouslt
inoicazis the
bacteria is
sensitive.
 Tuberculo
sis
 Hypersens
itivity
 Aethealgeas
 Nausea
 Vomiting
 Dysuria
 Malaria
fever
 Elevation of
plasma uric
acid
 Acute
episodes of
gout.
 Reduces serve
1NH
concentratio
n
 Cheek vital
signs
 Cheek for any
side effect
 Observe cough

45. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
ROU
TE
DOSE MODE OF
ACTION
INDICATION CONTRAI
NDIRATI
ON
SIDE
EFFECT
NURSING
RESPONSIBIL
ITIES
2 ERYTH
ROMYC
IN
- Oral 250m
g/kg
 It mainly
acts on gram
+ve cocci
 It acts
against
penicillin
resistant
staphylococc
i.
 URTI
 Acute
pneumonia
 Vaginitis
 Impetigo
 Wound &
burn
infection
 Whooping
cough
 Hypersens
itivity
 Mild to
sense
epigastria
pain
 Diarrhea
 Other
allergic
reactions

 May increases
serve digoxin
 Level so the
nurses should
be aware
about it.
 It reduces the
therapeutic
effect of
penicillin
terferadine &
astinizole
 It increases the
risk of the
adverse effect
on the heat so
cheek
continuously.

46. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICA
TION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
3 ETHA
MBUT
O
HYDR
OCHL
ORIDE















- Oral 15
mg/kg
 May inhibit
synthesis of on
or more
metabolites of
susceptible
bacteria
changing al
metabolism
during division.
 Pulmon
ary TB
 Children
younger than
13 years
 hypersensitiv
ity
 headache
 optic
nutritive
 anemia
 nausea
 GF upset
 Joint paint.
 Perform visual
aquity test &
Coloma that
before &
dividing
therapy.
 Ensure any
change in
vision
 Cheek any
other side
effects

47. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICA
TION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
4 ISONI
AZID
Isota
mine
Oral 10-15
mg/kg
 May inhibit all
wall
biosynthesis by
interfering rapid
& DNA
synthesis
 Activity
growin
g
tubercl
e
bacilli.
 Acute rap tie
disease
 Memory
impairment
 Hepatitis
 Jaundice

 Always give
drug other
anti-tubercle
drug to
prevent
development
of resistance
 Cheek for any
effect.

48. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICA
TION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
5 RIFAM
PICIN
- Oral/
IV
10-20
mg/kg
 Inhibit DNA
dependent RNA
polymerase
impairs RNA
synthesis
 Pulmon
ary TB
 Hypersensiti
vity
 Headache
 Fatigue
 Shock
 Drowsiness
 Hematuria
 Give drug
atleast other
anti TB drug
for best
absorption
 Monitor
hepatic
function
 Give capsule 1
hour before
or 2 hrs after
meal.
 Cheek for any
side effect

49. ANTI- VIRAL
DRUGS

50. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICAT
ION
CONTRAI
NDIRATIO
N
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
1 ACYCL
OVIR
- Oral 10
mg/kg
 It inhibits the
replication of
virus
 It has a
selective effect
on the virus out
affecting the
host
 It is highly
effective against
reaps viruses
 Neonatal
herpes
simplex
virus
infection
 Herpes
zoster
virus
infection
 Influenza
virus
infection
.
 Hypersensi
tivity
 Glaucoma
 Depression
 Pregnancy
 Lactation
 Penal
impairment
 Headache
 Nausea
 Vomiting
 Skin rash
 Vaginitis
 Alopecia
 Muscle
cramps
 Tremors

 Do not give
1m/se
 Monitor
mental
function
 Tell patient to
take drug as
prescribed
 Cheek for any
side effect

51. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICATIO
N
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
2 RIBAVI
RINE
- Oral/
IV
5-10
mg/kg
divided
dose
 It is a purine
nucleoside
analogue
 It Is a broad
spectrum of
antiviral
activity
against DNA
&RNA
viruses.




 Infection
 viral
infection
 respiratory
tract viral
infection
 influenza
virus
infection
 viral
hepatitis
 herpes group
of virus
 hypersensiti
vity
 anemia
 renal
impairment
 pregnancy
 lactation
 headache
 nausea
 vomiting
 skin rash
 cardiac arrest
 HTN
 Cheek vital
sigins
 Follow 6
rights for
administerin
g the drug
 Monitor renal
functions.

52. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICA
TION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
3 ZIDOV
UDINE
- Oral/
IV
2mg/kg  Nucleoside
reverse
transcriptase
inhibit
replication of
HIV of blocking
DNA synthesis
 HIV
infectio
n
 Hypersensiti
vity
 Lactation
 Pregnancy

 Nausea
 Vomiting
 Diarrhea
 Skin rash
 Headache
 Monitor blood
studies
 Cheek vital
signs
 Instinct the
patient to
take drug is
in cepty
stomach

53. BRONCHO – DIALATORS

54. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICA
TION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
1 ADREN
ALIZE
- IV/I
M
0.2-0.5
ml for
6hrs
 This is a patient
bronchodilator
 It also relieves
the pulmonary
congestion by
constricts the
pulmonary
arterioles
 The relief of an
attach of
adrenalin is
demotic but
may be
accompanied by
unpleasant
palpation
 It is helpful in
smooth muscle
relaxation.
 Beady
cardio
 Beady
arrhyth
mias
 Hypersensiti
vity
 Acute angle
closure
glaucoma
 Ischemia
 Obstructive
neuropathy
 Angina
 Nausea
 Headache
 Vomiting
 Sweating
 Use extreme
caution in
alkylating &
preparing
doses
 Any education
of adrenaline
that is turn to
pink should
not be given
 BP should
cheek every
15 minutes
 The drug
should be
injected
slowly.

55. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICAT
ION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
2 ATROPI
NE
SULHA
TE
- Oral/
IV
se
0.02-
0.15
mg/kg
 Anti-
cholinergic
that inhibits
acetyl choline
as pares ympa
their neuron
affect or
function
 Brady
cardiac
 Brady are
hythmias
 Hypersensiti
vity
 Acute angle
closure
glaucoma
 Ischemia
 Obstructive
uropathy






 Headache
 Insomnia
 Restlessness
 Palpitation
 Dey mouth
 Constipation
 Cheek for
tacky cardiac
 Cheek vital
signs
 Monitor I/O
chart

56. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICA
TION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
3 IPRATR
OPIUM
BROMI
DE
- Inhal
ation
0.3%  It inhibits
reflux by
antagonizing
ACH muco
curaine
receptor on
bronchial
smooth muscle.
 Broncho
spasm
 Rhinorr
hea
 Hypersensiti
ve

 Nausea
 Vomiting
 Blurred
vision
 Palpitation
 Chest pain
 GI distress
 dyspnea
 take care to
purulent
leakage
around the
nose
 the drug
should be
injected
slowly
 cheek for any
side effects

57. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICA
TION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
4 SALBU
TAMOL
- Oral 1mg/kg
6-8 hrs
 it is an odorless
white powder
 it also relive
the pulmonary
congestion by
constricts the
pulmonary
arterioles
 asthma
 emphys
ema
 bronchit
is
 myocardial
insufficiency
 hyperthyroid
ism
 pregnancy
 palpitation
 tremors
 tachycardia
 anorexia
 vomiting
 nausea

 cheek for any
side effect
 monitor vital
signs
 administer
drug by
follows 6
rights

58. CARDIOTONICS

59. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICA
TION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
1 DIGOXI
N
- Orall
y /IV
10-
15mg/k
g
0.8-
1mg/kg
for loyr
children
 a cardiac
glycoside that
increases the
influx of cat
wine from
extracellular to
intracellular
cytoplasm
 it is
antiarrhythmic
cardiac
glycoside
 CHF
 Atrial
fibrillat
ion
 Paroxys
m atrial
achy
cardiac
 Ventricular
fibrillation
 Hypersensiti
ve
 Ventricular
tacky cardiac
 Acute MI
 Sinus beady
cardiac
 Renal
disease
 Hypothec
disease
 Fatigue
 Headache
 Malaria
 Arrhythmia
 Anorexia
 Nausea
 Vomiting
 Diarrhea

 Do not
administer
rapidly by IV
route to
patient
receiving
diagnosis
 Instant patient
do not take
an extra dose
of digoxin
 Advise patient
to use some
beand
constantly

60. ANTI – NEOPLASTIC
DRUGS

61. SL
NO
.
NAME
OF
DRUG
TRA
DE
NA
ME
ROU
TE
DOSE MODE OF
ACTION
INDICATIO
N
CONTRAI
NDIRATIO
N
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
1 CYCL
OPHO
SPHA
MIDE

-















2-8
mg/
kg/
day
Oral/IV  An
alkylating
agent that
inhibits DNA
& RNA
protein
synthesis by
crossing
DNA & RNA
strands
 It preventing
cell growth.
 It is a potent
immune
suppressant

 Nephrotic
syndrome
 Hodgkin’s
disease
 Mycosis
 Fungoides
 Retinoblasto
ma
 Breast
carcinoma
 Ovarian
adenocarci
noma
 Hypersensi
tivity
 Bone
marrow
suppresses
 Impaired
renal/replica
function
 Leukopenia
 Nausea
 Vomiting
 Alopecia
 Diarrhea
 Darkening of
skin
 Stomatitis
 Headache
 Diaphoresis

 Monitoring
CBC,
differential,
platelet
count
 Renal function
studies,
BUN.UA,
serum, uric
acid
 Take the input
output
report.

62. SL
NO
.
NAME
OF
DRUG
TRA
DE
NA
ME
ROU
TE
DOSE MODE OF
ACTION
INDICATIO
N
CONTRAI
NDIRATIO
N
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
2 VINCR
ISTINE
SULFA
TE














- IV 1.4-2
mg/day
>10kg
50mg/k
g for
once
weekly
 It exceeds it
cytotoxic
activity by
assessing the
cell lysis is
the metap
bone protein
of cell
division
resulting cell
lysis
 Also inhibits
DNA
dependent,
RNA
synthesis
 Hodgkin
disease
 Neuronblast
oma
 Willm’s
tumor
 Hypersensi
tivity
 Hepatic
dysfunction
 Sensory loss
 Loss of deep
tendon
reflexes
 Diplopia
 Diarrhea
 Constipation
 Nausea
 Vomiting
 Anoxia
 Weight loss
 Encourage
adequate
fluid intake
to increase
urine output

63. SL
NO
.
NAME
OF
DRUG
TRA
DE
NA
ME
ROU
TE
DOSE MODE OF
ACTION
INDICATIO
N
CONTRAI
NDIRATIO
N
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
3 METH
OTRE
XATE
-























Oral /
IV
10-15
mg/day
 An anti
metabolite
that competes
enzymes
necessary to
reduce folic
acid to tetra
hydro folic
acid.
 It causes
death of
cancer cells.
 Trophoblasti
c neoplasm
 Notify
 Head &
neck cancer
 Chariot
carcinoma
 Acute
lymphocyti
c leukemia
 Rheumatic
arthritis
 Psoriasis
 Lymph
sarcoma
 Hypersensi
tivity
 Hepatic
dysfunction
 Nausea
 Vomiting
 Stomatitis
 Burning
 Erythema
 Diarrhea
 Rash
 Dermatitis
 Provirus
 Dizziness
 Alopecia
 Anorexia
 Malaria
 Headache
 Blurred
vission

 Provide
patient
fanuly
education
 Notify
clinician of
black, chills,
fever, sere
throat,
bleeding
 Diet 10-12
glasses of
fluid/day
 Assess lives
function tests

64. ANTI – RETROVIRAL
DRUGS

65. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICA
TION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
1 INDIN
AVIR
SULFA
TE



Crixi
van
500
mg
Oral  It prevents
cleavage of the
viral ply protein
by bindings to
the protease
active site
leading from
action of
immature non-
infections viral
particles.
 HIV
infectio
n
 Hypersensiti
ve
 Sever
hepatic
impairment

 Headache
 Malaria
 Insomnia
 Dizziness
 Abdominal
pain
 Nausea
 Vomiting
 Back pain
 Insect the
patient to
drink at least
1.5 L of
fluid daily
 Inform the
patient that
indinavir is
not a cure for
HIV
infection

66. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICA
TION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
2 ZIDOV
UDINE
-






160
mg
up to
200
mg/k
g for
neon
ate
Oral  It will prevents
the cleavage of
the vital poly
proteins by
binding to the
protease active
site
 HIV
infectio
ns
 Hypersensiti
ve

 Diarrhea
 Acid
regulation
 Dry mouth
 Flank pain
 Severe
headache
 Dizziness
 Convulsions
 Instruct the
patient to
drink at least
1.5 L of fluid
daily

67. SL
NO
.
NAME
OF
DRUG
TRA
DE
NAM
E
RO
UTE
DOSE MODE OF
ACTION
INDICA
TION
CONTRAIN
DIRATION
SIDE
EFFECT
NURSING
RESPONSIBI
LITIES
3 AZIDOT
HYMIDI
NE
- Oral/
IV
200-250
mg
every 4-
8 hrs.











 It is synthetic
analogue of
thymidine
 It acts by
inhibiting viral
transcriptase
 It crosses
placenta
 It decreases
mortality
 HIV
infectio
n
 Hypersensiti
vity
 Diarrhea
 Nausea
 Vomiting
 Dizziness
 Convulsions
 Instruct the
patient to
drink al least
1.5 L of fluid
daily
 Cheek for side
effects
 Monitor
continuously