Drug Delivery System.pptx

Drug delivery system mainly used to induced the medicines by using some targeted way that a person get more effect of that medicine. it can be nano particles which use to deliver the medicines

1. DRUG DELIVERY SYSTEM Health Biotechnology Superior University Group 8 Ayesha Hashmi Ayesha Yasin Usama Mukhtar

2. Drug Delivery System What are drug delivery devices? What Are the Four Drug Delivery Methods? Drug delivery technology Drug delivery technology companies Possible Systems for drug delivery Targeted drug delivery system Future Perspectives Content

3. Drugs Drugs have played a pivotal role in alleviating illnesses, enhancing well being, and extending both human and animal lifespans. Drug delivery system Drug delivery systems describe technologies that carry drugs into or throughout the body. What are drug delivery devices? Drug delivery devices are specialized equipment designed to facilitate therapeutic substances to patients. I NTRODUCTION

4. Syringes and Needles These are widely used for injections. Syringes allow for precise measurement and controlled delivery of liquid medications. Auto injectors These devices are designed to deliver a pre-measured dose of medication through a needle with the push of a button. They are often used for severe allergic reactions. Insulin Pens These are specialized devices used by people with diabetes to inject insulin. They offer a convenient and discreet way to self-administer insulin.

5. Nebulizers Nebulizers convert liquid medication into a fine mist that can be inhaled into the lungs. They are commonly used for respiratory conditions, such as asthma. Fig: Insulin Pen Fig: Nebulizers

6. Immediate Release The dosage form that is designed to give a rapid and complete release of the drug. Non-Immediate Release The dosage form encompassing drugs that do not fully release upon administration. What Are the Four Drug Delivery Methods?

7. Site-Specific Release  The dosage form that offers targeted delivery of a drug directly to the location where it is administered. Sustained Release The dosage form that releases a drug continuously at a slow or controlled rate over a prolonged period of time. What Are the Four Drug Delivery Methods?

8. DRUG DELIVERY TECHNOLOGY

9. Drug delivery technology means finding smart ways to give medicines to the body in a precise and controlled manner. It can take various forms, including drug-loaded nanoparticles, liposomes, micelles, implantable devices, and transdermal patches. DRUG DELIVERY TECHNOLOGY

10. Pharmaceutical Technology has listed companies providing products and services related to drug delivery, including: Oral drug delivery technologies Transdermal drug delivery systems Self-injection devices Automated test solutions for pharmaceutical drug delivery systems. DRUG DELIVERY TECHNOLOGY COMPANIES

11. • Insulet : This company is headquartered in Billerica, Massachusetts. It touts the OmniPod Delivery System, which is a tubeless system to deliver insulin. • Becton Dickinson : As one of the largest medical device companies in the world, Becton Dickinson is involved in innovative drug delivery development. • Ipsen SA and Insmed Inc : These companies are key patent filers in nanoparticles for drug delivery. DRUG DELIVERY TECHNOLOGY COMPANIES

12. POSSIBLE SYSTEMS FOR DRUG DELIVERY

13. Colloidal drug strategies involve utilizing drug carriers that contain microscopically dispersed drug particles suspended in a colloidal suspension. They are tiny and invisible delivery vehicles for medicines, such as micelles and liposomes. The purpose is to obtain systems with optimized drug loading and release properties, long shelf-life and low toxicity. COLLOIDAL DRUG CARRIERS

14. COLLOIDAL DRUG CARRIERS

15. Liposomes are spherical vesicles made up of biodegradable natural or synthetic phospholipids. They are amphipathic characterized by lipophilic tail and hydrophilic head on the same molecule. LIPOSOMES

16. Water-soluble drugs are trapped inside the hydrophobic core, while fat-soluble drugs are incorporated into the phospholipid layer of liposomes. Liposomes attach to cellular membranes and appear to fuse with them, releasing their or drugs into the cell. In the case of phagocytic cells, the liposomes are taken up, the phospholipid walls are acted upon by organelles called lysosomes, and the medication is released. LIPOSOMES

17. Liposome Doxorubicin Sulphate Lipid bilayer Incorporation in blood stream Liposome accumulation in tumor tissue EXAMPLE Fig: Mechanism of Liposome drug delivery system for tumor cells Endocytosis and Doxorubicin Sulphate releases Induce the Controlled death of tumor cells

18. Increased stability and decreased toxicity of encapsulated drug. Both hydrophilic and hydrophobic drugs can be carried. Non – toxic and non – pyrogenic. Advantages of Liposomes

19. Micelles are molecular aggregates formed by substances dispersed in a liquid phase from which they colloid. Micelles formed by self-assembly of amphiphilic block copolymers (5-50 nm) in aqueous solutions. MICELLES

20. Micelles have a protective shell that keeps the drug safe from breaking down in body or being destroyed by enzymes. The drugs can be physically entrapped in the core of block copolymer micelles, which can help them dissolve better in water. Fig: Micelles forming Assemblies MICELLES

21. Helps medicines to dissolve in water easily. Protects the medicines from breaking down in the body or being destroyed by enzymes. Advantages of Micelles

22. Drug delivery systems can provide advanced efficacy and decrease toxicity for anticancer agents. Anticancer drugs:- Anticancer drugs provide current information on the clinical and experimental effects of toxic and non-toxic cancer agents in cancer treatment. Fig: Protein and peptide delivery to lungs by using advanced targeted drug delivery system Targeted drug delivery system

23. Lung-specific drug delivery Pulmonary drug delivery offers several advantages in the treatment of respiratory diseases (such as pulmonary, arterial hypertension) over other routes of administration. Targeting to brain The great interest in mucosal vaccine delivery arises from the fact that mucosal surfaces represent the major site of entry for many pathogens.

24. Strategies for drug delivery to the brain: Several drugs do not have physiochemical characteristics such as high lipid solubility, low molecular size and positive charge which are essential to succeed in traversing BBB (blood brain barrier). Disruption of the BBB  Approach was to break down the barrier by injecting mannitol solution into arteries in the neck.

25. Nanoparticulate systems for brain delivery of drugs One of the possibilities to deliver drugs to the brain is the employment of nanoparticles. Other controlled drug delivery system Oral There is a great need in oral delivery of protein and peptide drugs, suitable devices for delivering the therapeutic agent. Parenteral  Medications placed into the tissues and the circulatory system by injection. 

26. The colon specific drug delivery System (CDDS)is beneficial not only for the oral delivery of proteins and peptide. It is also for the delivery of low molecular weight compounds used to treat diseases associated with the colon or large intestine. THE COLON SPECIFIC DRUG DELIVERY SYSTEM

27. Advances in surface technology of nanoparticles have allowed nanocarriers to engage applicants for future work involving targeted drug delivery and they are currently used to diagnose or treat several types of cancer. Additionally, there are different formulations, which are now in different stages of clinical trials to Enhance therapeutic efficacy Reducing toxicity Increasing patient compliance Enabling entirely new medical treatments. FUTURE PROSPECTIVES

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