Drugs causing ocular toxicity

it contains almost all the drugs which causing ocular toxicity.hope will useful for u guyz

1. DRUGS CAUSING OCULAR TOXICITY

2. INTRODUCTION Ocular toxicity,as all other areas of toxicology is a never ending,ever expanding branch till the scientist work and ophthalmologist prescribe Clinicians must base their decision on Available data Past experience Human variables

3. Toxicity may be of minor complications like Conjunctivitis Medicamentosa or aplastic anemia death

4. Ocular toxicology may be discussed in following lines Ocular manifestation of systemic medication Systemic manifestation following topical ocular medication Ocular complications following topical ocular preparations Agents affecting specific ocular areas

5. OCULAR MANIFESTATION OF SYSTEMIC MEDICATION

6. ANTI-INFECTIVE AGENTS: DRUG SIDE EFFECTS CHLORAMPHENICOL >>>>> optic neuritis central scotoma rare toxic amblyopia ETHAMBUTOL >>>>> inflammation of optic disc,nerve,tract color vision disturbance

7. ISONIAZID >>>>> optic neuritis optic atrophy NALIDIXIC ACID >>>>> minor visual disturbance color vision defects rare, papilloedema reversible sixth nerve palsy RIFAMPICIN >>>>> conjunctival hyperemia lacrimation SULFONAMIDE >>>>> conjunctival and corneal scarring steven -Johnson syndrome

8. GRISEOFULVIN >>>>> macular degeneration macular oedema papilloedema pseudotumour cerebri photosensitivity TETRACYCLINES >>>>> blurring of vision diplopia rare, papilloedema reversible pseudo tumour cerebri STREPTOMYCIN >>>>> optic neuritis

9. ANTI-PARASITE DRUGS: DRUGS SIDE EFFECTS AMODIAQINE >>>>> corneal deposit rare, retinopathy reversible CHLOROQUINE >>>>> corneal deposit CD is frequent bilateral macular degeneration reversible when total dose is more than 100gm irreversible macular change occurs

10. QUININE >>>>> retinal vascular disorders with cherry red spot at macula acute loss of vision with excessive doses partially toxic amblyopia reversible TRYPARSAMIDE >>>>> impaired vision optic atrophy reversible

11. ANTI-INFLAMMATORY AGENTS: DRUGS SIDE EFFECTS IBUPROFEN >>>>> disturbance of colour vision rare blurring of vision reversible optic neuritis INDOMETHACIN >>>>> corneal deposit rare diplopia reversible mydriasis possible retinal damage NAPROXEN >>>>> blurred vision scotomas

12. OXYPHENBUTAZONE >>>>> conjunctival and corneal scarring PHENYLBUTAZONE >>>>> steven -Johnson syndrome TOIMETIN >>>>> toxic amblyopia diplopia GOLD SALT >>>>> corneal deposits reversible ACETAMINOPHEN >>>>> steven -Johnson syndrome

13. CARDIOVASCULAR : DRUGS SIDE EFFECTS AMIODARONE >>>>> corneal deposit lens opacities reversible conjunctival hyperemia VASODILATOR-HYDRALAZINE >>>>> lacrimation conjunctivitis very rare QUANITHIDINE >>>>> ptosis

14. NERVOUS SYSTEM: DRUGS SIDE EFFECTS PENTAZOCINE >>>>> miosis hallucination PHENACETIN >>>>> xanthopsia ANTICHOLENERGICS >>>>> mydriasis problem in accommodation reversible raise in IOP in angle closure glaucoma

15. ANTI CONVULSANT: DRUGS SIDE EFFECTS PHENYTOIN >>>>> nystagmus diplopia frequent weakness of accommodation and convergence reversible TRIMETHADIONE >>>>> glare in bright light fading of colors reversible

16. ANTI DE-PRESSANTS: LITHIUM CARBONATE >>>>> blurred vision sodium def accommodative weakness reversible MONOAMINE-OXIDASE >>>>> changes in color perception INHIBITORS papilloedema rare visual acuity IMIPRAMINE DESIPRAMINE NORTRIPTYLINE >>>>> increased IOP frequent TRICYCLICS impairement of accommodation

17. ANTI-PARKINSONISM DRUG: DRUGS SIDE EFFECTS AMANTADINE >>>>> visual hallucination frequent in elders reversible BENZTROPINE >>>>> blurring of near vision dilatation of pupil

18. BENZODIAZEPINES & DERIVATIVES: DRUGS SIDE EFFECTS CHLORDIAZE POXIDE HCL >>>>> blurred vision reversible with overdose diplopia irreversible CLORAZEPATE DIPOTASSIUM >>>>> nystagmus DIAZEPAM diplopia allergic conjunctivitis

19. HYPONOTICS: DRUGS SIDE EFFECTS FENFLURAMINE >>>>> dilatation of pupil KETAMINE >>>>> visual hallucination rare nystagmus reversible

20. ANTI PSYCHOTIC: DRUGS SIDE EFFECTS CHLORPROMAZINE HCL >>>>> pigment deposition in anterior portion of lens & posterior cornea PERPHENAZINE >>>>> blurring of near vision enlarged pupil rare PROCHLORPERAZINE >>>>> uncontrolled eye movement PHENOTHIAZINES >>>>> conjunctival deposit corneal opacity retinal degeneration

21. HORMONES: DRUGS SIDE EFFECTS CONTRACEPTIVES >>>>> retinal haemorrhages papilloedema corneal edema & swelling rare nystagmus

22. THANK YOU

23. DONE BY V.YOGAPRIYA