DRUGS IN MOOD DISORDERS AND CENTRAL NERVOUS SYSTEM

DRUGS FOR MOOD DISORDER

2. Drugs in Mood DisordersDrugs in Mood Disorders
SS
TT
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DD
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TT
SS

3. Mood / Affective Disorders
• Depression
• Mania

4. Depression: Features in Most Cases
Mood 
•Mild sadness
to
•Intense feelings of:
•Guilt
•Worthlessness
•Hopelessness

5. Depression: Features in Most
Cases
Difficulty in Thinking
•Inability to concentrate
•To ruminate
•Lack of decisiveness

6. Depression: Features in Most
Cases
Loss of interest in:
•Work
•Recreation

7. Depression: Features in Most Cases
Somatic complaints
•Headache
Sleep disturbances
•Disruption
•Less sleep
•Excessive sleep
Others
•Loss of energy
•Change in appetite
•Sexual drive 
•Anxiety

8. Depression: In Some Cases
•Psychomotor retardation / Agitation
Delusion
•Hypochondriacal
•Persecutory
Activities
•Withdrawal
Major physical symptoms
•Anorexia
•Insomnia
•Sexual drive 
•Weigh loss
•Various other somatic complaints

9. Mania: Features
Mood
•Euphoria
•Irritability
Sleep
•Disruption
Hyperactivity
Racing thoughts
Grandiosity
Psyschotic symptoms

10. Classification: Antidepressants
NE Reuptake Inhibitors
•Tertiary Amine Tricyclics
•Secondary Amine Tricyclics
Selective Serotonin
Inhibitors
Atypical Antidepressants
MAO Inhibitors

11. NE Reuptake Inhbitors
Tertiary
amine TCAs
•Amitriptyline
•Imipramine
•Trimipramine
•Clomipramine
•Doxepine
Secondary
amine TCAs
•Desipramine
•Nortriptyline
•Protriptyline
•Maprotiline
•Amoxapine

12. Selective Serotonin
Reuptake Inhibitors (SSRIs)
•Citalopram
•Escitalopram
• Venlafaxine
•Fluoxetine
•Paroxetine
•Fluvoxamine
•Sertraline

13. Atypicals
•Bupropion
•Trazodone
•Nefazodone
•Duloxetine
•Atomoxetine
•Mirtazapine

14. MAOIs
•Phenelzine
•Tranylcypromine
•Selegiline

15. Mood - stabilizers
•Neuroleptics
•Clonazepam
•Lithium
•Valproic acid
•Carbamazepine
•Newer anticonvulsants
•Calcium channel blockers