Dry Powder Inhaler ppt.

Introduction of DPI

1. Graded Seminar Dry Powder Inhaler Submitted By- Mr. Tejas Chandrakant Jagtap M. Pharm (Pharmaceutics) 2 nd Semister Guided By- Dr. (Mrs.) Shilpa P. Chaudhari HOD, Pharmaceutics Dept. Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44. Dr. D. Y. Patil College of Pharmacy, Akurdi , Pune-411044.

2. Contents: Background Introduction & Definition Types of DPI Characteristics Advantages Disadvantages DPI formulation Carriers used in DPI Techniques for DPI Characterization of DPIs References 2 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

3. Background: N ot used as commonly in the United States as are MDIs . G reater variety in design and function of DPIs relative to MDIs. I nclude P re-metered and D evice-metered DPIs. Changes in design is done for reproducibility of the dose and particle size distribution . The most formidable challenge for DPIs is that to maintain the qualities till expiration period and functionality of device . 3 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

4. Introduction: What are Dry Powder Inhalers (DPIs) ? 4 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

5. Dry Powder Inhalers (DPIs) DPI is device that delivers medication to the lungs in the form of dry powder. DPIs are also commonly used to treat Respiratory Diseases such as asthma, bronchitis, emphysema and COPD . Either in a capsule or Inside the inhaler itself . Once loaded or actuated, the operator puts the mouthpiece of the inhaler into the mouth and takes a deep inhalation. 5 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

6. Dry Powder Inhaler (DPIs) Commonly used to deliver medications such as inhaled corticosteroids into the lungs.   This inhaler is breath-activated. The medication is released only when you take a deep, fast breath in through the inhaler. This is different than a metered dose inhaler that pushes medication into the lungs. Marketed examples of dry powder inhalers include: Advair Diskus , Asmanex , Pulmicort flexhaler . 6 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

7. 7 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

8. Types of DPIs: 8 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

9. Ideal Characteristics required for DPI’s Effective Dosing. Uniform dose through out life. Targeted and optimize delivery: Controlled respirable fraction. Inhalation of dose-independent aerosol generation. Bolus of aerosol available at the beginning of an inhalation. Operable at low inhalation flow rates. Continued…. 9 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

10. Ideal Characteristics required for DPI’s Good Environmental production. Design optimized by the use of, for e.g., particle engineering, manufacturing innovation, etc. In-process controls for quality. Compact, Portable, C heap, Reusable and Efficient d evice. Clear comparative data for complaint. 10 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

11. Advantages 11 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

12. Disadvantages 12 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

13. DPI Formulation Considerations: C onsist of the API or carrier powder mixed with drug (API). Particle size of drug should be < 5 μm. The micronization of drug is done by milling, spray drying, and supercritical fluid extraction. M icronized drug particle achieve good aerodynamic properties of the dispersed powder. Improvement in formulation performance by development of tertiary excipients like magnesium stearate and leucine . H elps in improving the performance of formulation by interfering with inter-particle bonding due to its antiadherent action . 13 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

14. Carriers used i n DPIs U sed to improve drug particle flow ability, improving dosing accuracy, minimizing the dose variability. T o facilitate the easy emission of drug particles from capsules and devices, thereby increasing the inhalation efficiency. Design of the carrier particle is important for the development of DPIs. C haracteristics of carrier particles include physico -chemical stability, biocompatibility and biodegradability. S hould be compatible with the drug substance and must be inert, available and economical. Examples of carriers: Lactose, mannitol, glucose, sorbitol, maltitol , and xylitol. 14 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

15. Advantages of lactose as a carrier 15 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

16. Techniques for DPI A ) Controlled crystallization or precipitation: Crystallization , or precipitation, is the process by which particles are produced from solution of the material in a suitable solvent. The formation of a stable, crystalline material is normally the target of this final step. In the production of materials for use in DPI products, however, the particle size of the crystallized product is normally too large. Subsequent reduction in particle size is then necessary and can significantly alter the physical nature of the material. 16 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

17. B) Micronization: Micronization involves high energy particle-size reduction technique that can convert coarse-diameter particles into particles <5µm in diameter. Types of equipment used as, jet or fluid energy mills and ball mills. All techniques involve applying a force on the particle, typically in the form of a collision, either particle-particle or particle-equipment. As the size of the particle decreases, the number of imperfection decreases. Techniques for DPI 17 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

18. C) Blending: It serves as a commonly used method for improving the flow ability, fill ability, and dispersability of small cohesive particles wherein the drug is blended with excipients particles. The objective of the mixing process is to produce an ordered powder in which the small particles attach themselves to the surface of larger “carrier” particles. The final product performance of a powder blend in DPI is ultimately depends on the individual drug and carrier properties as well as on the process by which they are blended. Techniques for DPI 18 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

19. D ) Pelletization: The process involves deliberate agglomeration of the fine drug material into less cohesive, larger units. Pelletization is usually achieved by vibratory sieving or any process that tumbles powder. The resultant pellets must be used in a system capable of deaggregating to an appropriate particle size for aerosol drug delivery . Techniques for DPI 19 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

20. Characterisation of DPIs 20 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

21. Characterisation of DPIs 21 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

22. References: https:// www.aaaai.org/conditions-and-treatments/conditions-dictionary/dry-powder-inhalers, dated on April14 th , 2017. Santosh Thorat, Tushar Mahajan, Sarika Meshram, ” Formulation And Product Development Of Dry Powder Inhaler: An Overview”, World Journal Of Pharmacy And Pharmaceutical Sciences, Volume 4, Issue 11, 639-655. Paul J Atkins, “ Dry Powder Inhalers: An Overview”, Conference Proceedings: Respiratory Care, Volume 50, No. 10, 1304-1312. “Guidance for Industry: Metered Dose Inhaler (MDI) and Dry Powder Inhaler (DPI) Drug Products”, “Chemistry , Manufacturing, and Controls Documentation”, U.S. Department of Health and Human Services, Food and Drug Administration, Centre for Drug Evaluation and Research (CDER ). http://www.malvern.com/en/industry-applications/sample-type-form/powders-granules /, dated on April26, 2017. http:// www.sympatec.com/EN/LaserDiffraction/INHALER.html , dated on April26, 2017. 22 Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-44.

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