Dry powder inhalers

Dry powder inhalers

1. Dry powder Inhalers SUBODH S SATHEESH 2 ND MPHARM DEPT OF PHARMACEUTICS ECPS Department of pharmaceutics 1 DPI

2. Introduction COPD Pulmonary dosage forms Inhaler technology PMDI Dry powder inhalers 2 DPI

3. Ideal characters Easy to use Multiple doses Moisture Accurate and uniform Consistent Minimize adhesion 3 DPI

4. Design Capsule opening mechanism Airflow Retention of capsule debris Mouthpiece design 4 DPI

5. Issues with design Single dose devices Multiple dose devices 5 DPI

6. Mechanism Impaction Diffusion Sedimentation Interception Electrostatic precipitation 6 DPI

7. Drug delivery Invitro Invivo 7 DPI

8. Inhalation devices Nebulizers Pressurized metered dose inhalers Dry powder inhalers 8 DPI

9. Factors affecting DPI devices Humidity Interparticulate forces Particle size Physical properties of powders Carrier and size 9 DPI

10. characterization Crystallinity Polymorphism Moisture content Particle size Forces of interaction 10 DPI

11. Micronization Fluid energy mill Ball mill Pin mill 11 DPI

12. Evaluation Appearance Colour Sieve analysis Moisture content Spray pattern Flow properties 12 DPI

13. Current trends Twisthaler Handihaler Turbuhalers Easyhaler 13 DPI

14. CONCLUSION Drug delivery to lungs Improves aerosol delivery systems High patient compatibility High dose carrying capacity Treatment of asthma and COPD DPI 14

15. Bibliography Frijilink H W, Dry powder inhaler for pulmonary drug delivery IJPR 2015; 1(1);67-86. Nithi yadav , Alka lohani , Dry powder inhalers. A review, Indo global journal of pharmaceutical sciences, 2014;3(2);141-171 Newman SP, Evolution of dry powder inhalers formulation and perfomance . Respiratory care 2013 1209-1223 Mark copley , accessing Dry powder inhalers. Copley scientific 2012;(3):1027-1028 Sahane SP, Nikhar AK. Dry powder inhalers, IJPC 2011;(3) 1143-1149. DPI 15

16. 16 DPI THANKS FOR LISTENING