Ectoparasiticides

scabies
parasites

1. Ectoparasiticides
Used to kill parasites that live on
the body surface

2. 1.Lice – Pediculus wingless insects
2.Mites – Sarcoptes /Acrus scabiei

3. Drugs
Permethrin
Lindane (BHC)
Benzyl Benzoate
Crotamiton
Sulfur
Dicophane (DDT)
Ivermectin

4. Permethrin
Most convenient drug for scabies and lice
Delayed depolarization  neurological
paralysis in insects
Minimal systemic absorption
Nearly 100% cure rate in scabies and
pediculosis
Single application is needed in most cases
No development of resistance

5. Lindane
Affects the nervous system
For head lice and scabies
Single treatment needed
Efficacy is lower than Permethrin
Both Lice and mites can develop resistance to
Lindane
Lindane + Benzylbenzoate  avoids resistance
,improves the cure rate to 100%
Systemic toxicity

6. Benzyl Benzoate
Aromatic
Scabies
Convenient
CI in children
2
nd
choice for scabies
Not used for pediculosis

7. Crotamiton
Effective scabicide , pediculocide , anti
pruritic
Preferred in children

8. Ivermectin
Antihelminthic drug
Scabies and pediculosis
Only orally, administered drug for ectoparasites
0.2 mg / kg - single dose
AIDS patient with scabies also respond
CI – children , 5 yrs
CI in pregnancy and lactation
First line for scabies and pediculosis