effect of maternal drugs on fetus and neonates.pptx

effect of maternal drugs on foetus and neonates.pptx midwifery and gynaecology presentation

1. SHRI SHANKARACHARYA COLLEGE OF NURSING SUBJECT :MIDWIFERY &OBSTETRICS TOPIC : Effect Of Maternal Medication On Fetus & Neonates Presented by HONEY DAS B.SC NURSING 4 TH YEAR

2. INTRODUCTION NEW MEDICINES ARE SUBJECTED TO RIGOROUS TESTS BEFORE BEING RELEASED FOR CLINICAL USE.EVERY NEW DRUGS IS TESTED FOR ACTIVITY,POTENCY,&TOXICITY.IT IS TESTED ON PREGNANT LABORATORY ANIMALS.

3. DEFINITION

4. FETUS : FETUS IS THE DEVELOPING BABY BETWEEN THE EIGHTH WEEK & THE END OF PREGNENCY NEONATE NEONATE IS A NEW BORN SPECIALLY PERTAING TO A BABY UNDER ONE MONTH

5. MATERNAL-FETAL DRUG TRANSFER PRIOR TO IMPLANTATION DURING ORGANOGENESIS FROM SECOND TRIMESTER

6. MATERNAL MEDICATION WITH ESTABLISHED TERATOGENIC PROPERTIES AND THEIR EFFECTS CYTOTOXIC DRUGS :- MULTIPLE FETAL MALFORMATIONS AND ABORTIONAS. ANDROGENIC STEROIDS HYDROXY PROGESTRON LITHIUM:- NEONATAL GOITER, CONGENITAL MALFORMATION ,HYPOTONIA & CYNOSIS. MACULINIZATION OF FEMALE OFFSPRING .

7. POSSIBLE TERATOGENS. ANTI THYROID DRUGS:- GOITER ,MENTAL RETARDATION. ORAL ANTIDIABETIC DRUGS:- ABNORMALITIES IN THE EYE ,CNS,SKELETAL SYSTEM & NEONATAL HYPOGLYCEMIA. VITAMIN D:- CARDIOPATHIES ,HYPERCALCEMIA &MENTAL RETARDATION. LSD:- CHROMOSOMAL ABNORMALITIES & SLUNTED GROWTH.

8. CONT…. ANTICONVULSANTS:- MENTAL RETRDATION , CARDIAC ABNORMALITY ,LIMB DEFECT ,NEONATAL BLEEDING &EPILEPSY.

9. FETOTOXIC DRUGS ASPIRIN:- PREMATURE CLOSURE OF DUCTUS ARTERIOSIS,PULMONARY HYPERTENSION & KERNICTERUS IN THE NEWBORN. CORTICOSTEROIDS:- -FETAL AND NEONATAL ADRENAL SUPRESSION. AMINOGLYCOSIDES:- AUDITORY OR VESTIBULAR DAMAGE. CHLORAMPHENICOL:- PERIPHERAL VASCULAR COLLAPSE . TETRACYCLINE:- DENTAL DISLOCATION AND DEFORMITY,INHIBITION OF BONY GROWTH. LONG ACTING SULPHONAMIDES:- NEONATAL HEMOLYSIS ,JAUNDIS AND KERNICTERUS.

10. CONT.. ALCOHOL AND SMOKING:- IUGR,PRETERM LABOUR, MENTAL RETARDATION. NARCOTICS:- DEPRESSION OF CNS, APNEA, BRADICARDIA AND HYPOTHERMIA. ANESTHETIC AGENT:- CONVULSION,BRADYCARDIA, ACIDOSIS,HYPOXIA AND HYPERTONIA. ANTIHISTAMINES:- TACHYCARDIA ,VOMITTING ,DIARRHOEA. ANTI COAGULANTS:- OPTIC ATROPHY,MICROCEPHALY .

11. CONT.. DIURETICS:- FETAL COMPREMISE DUE TO DIMINISHED PLACENTAL PERFUSION. BETA BLOCKERS:- IUGR, FETAL BRADYCARDIA AND IMPAIRED FETAL RESPONSE TO HYPOXIA . VITAMIN K:- HYPERBILIRUBINEMIA AND KERNICTERUS.

12. MATERNAL DRUG INTAKE & BREAST FEEDING FACTORS CHEMICAL PROPERTIES MOLECULAR WEIGHT DEGREE OF PROTIEN BINDING IONIC DISSOCIATION LIPID SOLUBILITY TISSUE pH DRUG CONCENTRATIN EXPOSURE TIME

13. EFFECTS ON NEONATES

14. BROMIDES:- RASH ,DROWSINESS&POOR FEEDING IODIDES:- NEONATAL HYPOTHYROIDISM CHLORAMPHENICOL:- BONE MARROW TOXICITY . ORAL PILLS:- SUPRESSION OF LACTATION. BROMOCRIPTINE :- SUPRESSION OF LACTATION METRONIDAZALE:- ANOREXIA ,BLOOD DYSCARIASIS,IRRITABILITY,WEAKNESS&NEUR-OTOXIC DISORDER.

15. CONT…. ANTI COAGULANTS:- HAEMORRHAGIC TENDENCY. ISONIACID:- ANTI D.N.A. ACTIVITY & HEPATOTOXICITY . ANTI THYROID DRUGS AND RADIOACTIVE IODINE:- HYPOTHYROIDISM & GOITER . ANTIMETABOLITES:- ANTI DNA ACTIVITY, IMMUNOSUPRESSION . DIAZEPAM:- SEDATION EFFECT WITH POOR SUCKING REFLEX

16. CONCLUSION

17. THANK YOU