Eosinopenia

presented by HAFIZ M WASEEM
university of education LAHORE Pakistan
i am from mailsi vehari and studied in lahore
bsc in science college multan
msc from lahore

1. HAFIZ M WASEEM UNIVERSITY OF EDUCATION LAHORE

2. Table of Contents Serial # CONTENTS EOSINOPENIA Symptoms Causes Treatment Conclusion

3. AN OVERVIEW There are number of elements in the circulating tissue called as the blood.There are three types of Blood Elements: RBC’S (Erythrocytes) WBC’S (Leukocytes) Blood Platelets (Thrombocytes) The main discussion point is the Eosinophils related disorder. Our WBC’s are composed of 1.Neutrophils 2.Eosinophils 3.Basophils The Eosinophils are little larger than the neutrophil. The granules are spherical. They have three lobed nuclei.

4. Now, as our main concern is about eosinophils; in normal healthy person normal number of eosinophils are 1-3% in the peripheral blood. Now, in abnormal condition there are two poosibilities: Eosinophil level may increase called as eosinophilia, It may decreasefrom the normal called as eosinopenia.

5. Eosinopenia In precised term a characteristic the decrease in the eosinophil level of peripheral blood is called as the eosinopenia. It is considered low a number of less than 50-100 eosinophils per mm 3 of blood..

6. ACTIVITY OF EOSINOPHILS

7. Symptoms of Eosinopenia The reason for having no particular symptom is because the eosinopenia is associated with the low number of cells in the peripheral blood. It can occur together with the symptoms of other diseases Fever Infection Hives Asthma Allergic Reactions Stroke Immunoglobins deficiency Auto immune disorders.

8. The most important of the case which I could never be able to neglect is the symptom of pandemic COVID-19 also has the shortage of the Eosinophils. AcutePancreatitiss Acute Upper Gastrointestinal Bleeding. Acute Myocardial Infarction. Cerebrovascular Accident. Typhoid Fever. Rash . Leptospirosis. Fever of Unknown Origin Inflammation of Unknown Region.

9. Causes of Eosinopenia 1.Inflectional Effect: When there is accumulation of these cells occur in the tissues or the organs where there is bacterial infection, or the parasite present; these cells become less in the blood flowing in the periphery of the body. It means the infection whether it is viral or bacterial can induce eosinopenia. 2.Corticosteroid Drug: When the high dose of this drug is implemented it can also lead to the eosinopenia because it decreases the amount of Eosinophils

10. 3.Stress: Stress is also the factor of the eosinopenia because under stress internal corticosteroid and epinephrine production lowers the total number of Eosinophils around.

11. DIAGNOSIS The diagnosis of eosinopenia occurs by Absolute eosinophil count. Also the Hemogram exhibits the amount of the eosinophils in the peripheral blood.  Less than 40 eosinophils per mm 3 of blood and more than 10,000 leukocytes per mm 3blood test, the specificity and the positive predictive value for bacterial infection is 100%.(Disease inicator) The Eosinopenia severe (less than 10 eosinophils / mm 3 ) is a very specific marker for sepsis (a potentially fatal syndrome caused by an excessive immune response to infection) in the emergency department.

12. TREATMENT It is necessary to determine what the cause may be in order to apply the correct treatment. If the cause of eosinopenia were only stress , medications could be used to lower its levels. 

13.  If the cause was the administration of corticosteroids , this medication could be substituted for another or the doses could be adjusted and the risk / benefit ratio evaluated. Regarding the cause of infections, the application of the correct antimicrobial therapy (antibiotics, antiparasitics) would result in a rapid resolution of the eosinopenia. 

14. Conclusion: Although by itself it is not a cause for concern, if it occurs together with these alterations, the cause should be evaluated. It can also be used as an  indicator for infections.   The treatment of eosinopenia goes through establishing the causes and acting on them.