Epinephrine and Norepinephrine.pptx

4,524 views 15 slides Oct 09, 2022
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About This Presentation

Physiology and biochemistry of epinephrine and norepinephrine


Slide Content

Neurotransmitters – Epinephrine and Norepinephrine Dr Zaid Azhar

Epinephrine Also known as Adrenaline Catecholamine, Derived from phenylalanine and tyrosine Molecular weight – 183g

Synthesis

Adrenergic Receptors

Adrenergic Receptors

Adrenergic Receptors

Mechanism of Action

Mechanism of Action

Uses of Adrenaline Resuscitation Management of anaphylaxis Inotropic support in hypotension, shock, status asthmaticus

Norepinepherine Catecholamine with multiple roles: Hormone Neurotransmitter

Synthesis

Functions Stress hormone Fight-or-flight response Increases heart rate Triggers the release of glucose Increases blood flow to skeletal muscle. Suppress neuro-inflammation

Actions Potent action-both a1 & b1 receptors Little action on b2 Causes potent vasoconstriction ( α) Lacks bronchodilating effect ↑ systolic, diastolic & MAP Reflex bradycardia Metabolic acidosis

Comparison