Epinephrine and Norepinephrine.pptx

Physiology and biochemistry of epinephrine and norepinephrine

1. Neurotransmitters – Epinephrine and Norepinephrine Dr Zaid Azhar

2. Epinephrine Also known as Adrenaline Catecholamine, Derived from phenylalanine and tyrosine Molecular weight – 183g

3. Synthesis

4. Adrenergic Receptors

5. Adrenergic Receptors

6. Adrenergic Receptors

7. Mechanism of Action

8. Mechanism of Action

9. Uses of Adrenaline Resuscitation Management of anaphylaxis Inotropic support in hypotension, shock, status asthmaticus

10. Norepinepherine Catecholamine with multiple roles: Hormone Neurotransmitter

11. Synthesis

12. Functions Stress hormone Fight-or-flight response Increases heart rate Triggers the release of glucose Increases blood flow to skeletal muscle. Suppress neuro-inflammation

13. Actions Potent action-both a1 & b1 receptors Little action on b2 Causes potent vasoconstriction ( α) Lacks bronchodilating effect ↑ systolic, diastolic & MAP Reflex bradycardia Metabolic acidosis

14. Comparison