excretory system, EXCRETION KIDNEY ITS FUNCTIONS

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1. GENITOURINARY SYSTEM

2. INTRODUCTION The genitourinary tract begins at the kidneys, a retroperitoneal organ whose primary function is to filter blood and secrete waste products as urine. 

3. SYSTEM CONSISTS OF 2 kidney- Secretes urine 2 ureters- Conveys urine from kidney to urinary bladder Urinary Bladder- Where urine collects & temporary stored. Urethra- Urine is discharged from the renal system. Location- It occupies E pigastric , Hypochondriac, Lumber, umbilical region. Extend from- Upper border of 12 th TV to centre of 3 rd LV in adults.

4. KIDNEY Right kidney is Lower than left because of some space occupies by liver. Bean shaped organ: Reddish Brown Long- 11-12 cm Wide- 6 cm Thick- 3 cm Weight- Male- 150 gm Female- 135 gm Total renal blood flow 1200 ml/ mt. Receives 20% of cardiac output. Filter 200 liters of Blood daily.

5. URETERS Slender shape conveys urine from kidney to urinary bladder. Ureters enters base of the bladder by posterior walls. 3 cm in diameter. It is about 25-30cm long 10 cm in abdomen & 15 cm in pelvic cavity.

6. URINARY BLADDER Mascular hollow organ Reservoir of urine. It is pear shaped become more oval as it fills with urine. Capacity- 600-800 ml Residual volume- 50ml

7. URETHRA Male- it is about 19-20cm long . Female- it is about 4cm long 6 mm in diameter. Sizes of Urinary Catheter- Male- 16-18 Fr. Female- 14-16 Fr. Children- 6-8 Fr.

8. NEPHRONS Filtering functional units of kidney are Nephrons Approximately 1 million Nephrons in each kidney 3 cm long. Location- Between within cortex & Medulla of each kidney.

9. Highly Nitrogenous toxic waste- Ammonia NH3 (9.5-50 mcg/dl) Pressure in Bowman’s Capsular Space- 10mmHg Glomerular Capillaries Pressure- 50-70 mmHg

10. URINE Composition H2O- 96% Urea- 2% Other Substance- 2% Clear amber color due to presence of urobilin . Urine output 1-1.5 L/day average 30 ml/Hr. Obligatory urine Volume- 500ml-700ml/day or 30 ml/ hr (min. OP of urine necessary to remove waste) Normal Level of urobilin - 0.2-1.0 mg/ dL . pH- 6 Slightly acidic

11. Blood urea Nitrogen- 7-20mg/dl Male- 8-25 mg/dl Female- 6-21mg/dl children- 5-18mg/dl Pregnant women- 5-12mg/dl Creatinine - 0.6-1.3 mg/dl Uric acid Male- 4.0-8.5 mg/ dL Female- 2.7-7.3 mg/ dL Urea- End product of protein metabolism Creatinine - End product of muscle creatinine catabolism . Uric acid- End product of Purin BUN:Creatinine 10:1 Indicators of kidney functions

12. Specific gravity- shows the concentration of urine. Ranges- 1.010-1.025 Hypersthenurea - Increased Isosthenurea Hyposthenurea - Decreased

13. URINE FORMATION

14. FUNCTIONS Filter-  Every day, the kidneys filter fluid from the bloodstream. Waste processing-  The kidneys then process this filtrate, allowing wastes and excess ions to leave the body in urine while returning needed substances to the  blood in just the right proportions. Elimination-  Although the  lungs and the skin also play roles in excretion, the kidneys bear the major responsibility for eliminating nitrogenous wastes, toxins, and drugs from the body .

15. Regulation-   The kidneys also regulate the blood’s volume and chemical makeup so that the proper balance between  water and salts  and between  acids and bases  is maintained. Other regulatory functions-  By producing the enzyme renin, they help regulate blood pressure and their hormone erythropoietin stimulates red blood cell production in the bone marrow. Conversion-  Kidney cells also convert vitamin D to its active form .

16. Function of the Excretory System The human excretory system functions to remove waste from the human body. During this process animals get rid of nitrogenous waste products of metabolism, including ammonia, urea, and uric acid. Although excretory systems are diverse, nearly all produce urine in a process that involves several steps. K idneys Ureters Urinary bladder U rethra Organs of the Excretory System © iTutor . 2000-2013. All Rights Reserved

17. Filtration: The excretory tubule collects filtrate from the blood. Water and solutes are forced by blood pressure across the selectively permeable membranes of a cluster of capillaries and into the excretory tubule. Reabsorption: The transport epithelium reclaims valuable substances from the filtrate and returns them. Secretion: Other substances are extracted from body fluids and added to the contents of the excretory tube. Excretion: The filtrate leaves the system and the body. © iTutor . 2000-2013. All Rights Reserved Function of the Excretory System

18. Structure of the Excretory System This system consists of specialized structures and capillary networks that assist in the excretory process. The human excretory system includes the kidney and its functional unit, the nephron . The excretory activity of the kidney is changed by specialized hormones that regulate the amount of absorption within the nephron . Excretory System Bladder Kidneys Urethra Ureters Meatus

19. Kidney Located both sides of the spine between thoracic and lumbar vertebrae. Blood enters the kidneys through renal arteries and leaves through renal veins. Tubes called ureters carry waste products from the kidneys to the urinary bladder for storage or for release . During urination, urine is expelled from the urinary bladder through the urethra.

20. Flow of Urine Flow of Urine Glomerulus Renal Tubules Renal Pelvis Renal C alices Ureters Renal cortex Renal capsule Renal medulla Ureter Renal vein Renal artery Nephron Urinary Bladder Urethra

21. Parts of the Kidney Parts of the kidneys Cortex - outer protective portion Medulla - inner soft portion Hilum - a depression located in the middle of the concave side of the kidney where blood vessels, nerves, and the ureters enter and exit the kidneys Cortex Medulla Hilum The cortex is where the blood is filtered. The medulla contains the collecting ducts which carry filtrate (filtered substances) to the pelvis. The pelvis is a hollow cavity where urine accumulates and drains into the ureters.

22. The functional units of the kidney are called nephrons. Nephrons are located in the renal cortex, except for their loops of Henle, which descend into the renal medulla. Nephron

23. Two parts Renal Corpuscle Bowman Capsule Glomerulus Fenestrae - pore in endothelial walls of glomerulus. Podocytes - specialized cells. Filteration slits Renal Tubule - Series of single layer tubules 1 . Proximal Convoluted tubule 2. Loop of Henle 3. Distal Convoluted tubule Nephron Kidneys are made up of nephrons . Blood enters the nephron , where impurities are filtered out and emptied into the collecting duct. The purified blood leaves the nephron through the renal vein. © iTutor . 2000-2013. All Rights Reserved

24. Artery Vein Loop of Henle Bowman’s capsule Glomerulus Capillaries Collecting duct To the ureter Nephron

25. The glomerulus is a mass of thin-walled capillaries. The Bowman’s capsule is a double-walled, cup-shaped structure. The proximal tubule leads from the Bowman’s capsule to the Loop of Henle. The loop of Henle is a long loop which extends into the medulla. The distal tubule connects the loop of Henle to the collecting duct. Each nephron has its own blood supply: An arteriole A venule A network of capillaries connecting them Each nephron releases fluids to a collecting duct, which leads to the ureter.

26. Each kidney contains more than 1 million nephrons . Blood Flow through the Kidneys Blood enters through the renal artery Arterioles Each arteriole leads to a nephron Renal corpuscle The glomerulus filters fluid from the blood, and is the first place where urine is formed in the kidneys. Blood flows through the glomerulus at a constant rate. Each glomerulus is surrounded by a capsule known as Bowman’s capsule. Blood then passes into the renal tubules where some substances are reabsorbed and the remaining become urine.

27. The Kidneys As blood enters a nephron through the arteriole, impurities are filtered out and emptied into the collecting duct . The purified blood exits the nephron through the venule . The mechanism of blood purification involves two distinct processes: Filtration Reabsorption

28. Filtration   Passing a liquid or gas through a filter to remove wastes is called filtration. The filtration of blood mainly takes place in the glomerulus. The glomerulus is a small network of capillaries encased in the top of the nephron by a hollow, cup-shaped structure called Bowman's capsule. Fluid from the blood flows into Bowman’s capsule. The materials filtered from the blood include water, urea, glucose, salts, amino acids, and some vitamins. Plasma proteins, cells, and platelets remain in the blood because they are too large to pass through the capillary walls.

29. Reabsorption   Most of the material removed from the blood at Bowman's capsule makes its way back into the blood. The process in which liquid is taken back into a vessel is called reabsorption . Almost 99% of the water that enters Bowman’s capsule is reabsorbed into the blood. When the filtrate drains in the collecting ducts, most water and nutrients have been reabsorbed into the blood. Glomerulus Afferent arteriole Efferent arteriole Bowman’s capsule Glomerular Filtration

30. Remaining material, called urine, is emptied into a collecting duct. Urine is primarily concentrated in the loop of Henle. The loop of Henle is a section of the nephron tubule in which water is conserved and the volume of urine minimized . As the kidney works, purified blood is returned to circulation while urine is collected in the urinary bladder. Urine is stored here until it is released from the body through a tube called the urethra.

31. Ureters Ureters Peristalsis, a rhythmic contraction of the ureter smooth muscle which helps to move the urine into the bladder. A tube approximately 6 to 7 inches long attached to each kidney. Made up of three layers of tissue Smooth muscle Fibrous tissue Mucous layer Ureter

32. Urinary Bladder Urinary Bladder Hollow, muscular organ that stores urine Sphincter muscles hold the urine in place Holds 300 to 400 milliliters of urine before emptying Walls contain epithelial tissue that stretch to allow the bladder to hold twice its capacity Urethra Prostate gland Ureter Urinary bladder The trigone is a triangular area at the base of the bladder where the ureters enter and the urethra exits

33. Urethra Urethra Female Urethra Male Urethra Approximately 1.5 inches long Opens through the meatus Approximately 8 inches long Passes through three different regions: Prostate gland Membranous portion Penis A tube of smooth muscle with a mucous lining that carries urine from the bladder to the outside of the body.

34. Tiny pores in the tubing allow salts and small molecules to pass through. Wastes diffuse out of the blood into the fluid-filled chamber, allowing purified blood to be returned to the body. Dialysis Air detector Dialysis machine Fresh dialysis fluid Compressed air Vein Artery Shunt Blood pump Blood in tubing flows through dialysis fluid Used dialysis fluid Blood is removed by a tube and pumped through special tubing that acts like nephrons .

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