EXPERIMENTAL PHARMACOLOGY ppt for mmbs bds

experimental Pharmacology 01.09.2021 for mbbs

1. EXPERIMENTAL PHARMACOLOGY

2. 1. Identify the instrument which is used in experimental pharmacology 2. Mention its uses 3. Mention various group of drugs evaluated using this instrument 4. Mention the clinical uses of these drugs

3. 1. Rotarod 2. Widely used to evaluate drug effects on motor coordination, balance and motor learning in rodents. 3. Benzodiazepines, Skeletal muscle relaxants and neuroleptics etc. 4. Anxiety, Convulsions, Skeletal muscle spasms

4. frog heart Effect of various agonists of frog heart contractions Effect of various agonists in presence of antagonists on frog heart contractions

5. 1. Name some cardiac stimulants 2. Name some cardiac depressants 3. Which adrenergic receptor involved in cardiac stimulation 4. Cardiac use of atropine

6. 1. Adrenaline increases both heart rate and amplitude. Tone is same. Atropine increases heart rate without any incrase in amplitude and tone. CaCl 2 - only tone is increased and heart stops in systole 2. Acetylcholine - de creases both heart rate and amplitude. Propranolol decreases heart rate and amplitude KCl decreases tone and heart stops in diastole 3. β 1 adrenergic receptors 4. Vagally induced bradycardia and partial heart block

7. 1.Describe the given experiment. 2.Identify the test drug, with reasons. 3.Name one drug which reduces the ciliary motility 4.Name some anticholinergic agents used in GIT

8. 1. Effects of drugs on frog's ciliary movement 2. ACh, muscarinic receptor agonist, increases ciliary motility, thereby reduces the duration to travel 3. Atropine, antimuscarinic agent, reduces the motility. 4. Hyoscine-GI spastic conditions Propantheline and Oxyphenonium-peptic ulcer and gastritis

9. 1. Describe the graph 2. Identify the test drug. 3. What is the type of interaction of test drug with ACh. 4. Mention the therapeutic uses of the test drug

10. 1. Isolated tissue experiment, demonstrating action of ACh, Physostigmine on frog rectus muscle 2. Physostigmine 3. Pharmacokinetic interaction. reversibly inhibits the choline esterase, thereby potentiates the action of acetyl choline. 4. In glaucoma, belladona poisoning

11. 1. Describe the graph 2. What is the type of interaction of d-Tc with ACh. 3. Mention the therapeutic uses and adverse effects of the d-Tc 4. Name two drugs which potentiates the actions of d-Tc

12. 1. Isolated tissue experiment, demonstrating action of ACh, d-Tc on frog rectus muscle 2. Competitive antagonism, acts at NMJ (N M receptors) 3. Used as Skeletal muscle relaxant. And adverse effects are Respiratory paralysis and prolonged apnoea. 5. Halothane, Gentamicin, Verapamil