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Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female
reproducve tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepac
synthesis of s** hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and
suppress follicle-smulang hormone (FSH) from the anterior pituitary. Drospirenone is progesterone, and
together with estradiol, it can provide contracepon by suppressing release of ovum (eggs) from your ovary, and
interfering with other mechanisms that support occurrence of pregnancy. It suppresses the natural progesterone
in the body, and thereby helps in PMDD and acne. Its mechanism of acon in prevenon of osteoporosis is not
known.
What is Ethinyl estradiol and Drospirenone
Ethinyl estradiol and Drospirenone also sold under the brand name Yaz is a birth control pill. It works by
prevenng ovulaon or the release of a female egg from the ovaries. It also causes changes in the cervical and
uterine lining making the cervical mucus more viscous thereby making it harder for male sperms to reach the
uterus and also for a ferlized egg to aach to the uterus wall.
This pill is used as a contracepve method to prevent pregnancy. It is also used in treang moderate acne in
women who are above 14 years of age and have started geng their periods, and who also wish to use
contracepon to avoid pregnancy.
Ethinyl estradiol/Drospirenone is also used for alleviang the symptoms of premenstrual dysphoric disorder
(PMDD), such as depression, anxiety, irritability, concentraon troubles, lethargy, changes in sleep paerns or
appete, muscle or joint pain, tender breasts, and weight gain.
This pill may also be given for treatments beside those listed above.
Important Information about Ethinyl estradiol and Drospirenone
Ethinyl estradiol and drospirenone is not recommended if you are pregnant or if you have recently delivered a
baby. You must also not take this pill if you are suffering from any of these condions: heart disease, out of control
high blood pressure, blood clong disorder, problems with circulaon, problems in eyes or kidneys due to
diabetes, unexplained vaginal bleeding, liver disease or liver cancer, migraine, if you are smoker and above 35,
breast or uterine cancer, jaundice due to birth control pills, or a heart aack or a stroke in the recent past.
You may need to employ an alternate birth control method such as condoms or spermicide in the inial few days
of starng with the pills or if you happen to miss a dose. Consult your doctor for more details.
Always store ethinyl estradiol and drospirenone pills in a cool and dry place away from heat, light, moisture,
children and pets.
Before taking Ethinyl estradiol and Drospirenone