Formulation and evaluation of fast dissolving tablets

The concept of mouth dissolving drug delivery systems (MDDDS) or fast dissolving tablets emerged with an objective to improve patient’s compliance.
These dosage forms rapidly disintegrate and/or dissolve to release the drug as soon as they come in contact with saliva, thus obviating the need for water during administration, an attribute that makes them highly attractive for pediatric and geriatric patients.

1. FORMULATION AND
EVALUATION OF FAST
DISSOLVING TABLETS
By
Suryakantverma
Under the Supervision of
Dr. VIKESH KUMAR SHUKLA
Assistant Director
DEPARTMENT OF PHARMACEUTICS
IIMT COLLEGE OF MEDICAL SCIENCE
GANGA NAGAR, MAWANA ROAD, MEERUT,
UTTAR PRADESH, INDIA

2. Sr.no .Topic Slide no
1. INTRODUCTION 1
2. AIM AND OBJECTIVE 2
3. FORMULATION REVIEW 3-5
4. LITERATURE REVIEW 6-7
5. PLAN OF WORK 8-10
6. EXPECTED OUTCOMES 11
7. REFERENCE 12
Content

3. INTRODUCTION

4. Theconceptofmouthdissolvingdrugdelivery
systems(MDDDS)orfastdissolvingtabletsemerged
withanobjectivetoimprovepatient’scompliance.
Thesedosageformsrapidlydisintegrateand/or
dissolvetoreleasethedrugassoonastheycomein
contactwithsaliva,thusobviatingtheneedforwater
duringadministration,anattributethatmakesthem
highlyattractiveforpediatricandgeriatricpatients.
Difficultyinswallowingconventionaltabletsand
capsulesiscommonamongallagegroups,especiallyin
elderlyanddysphagicpatients.

5. AIM AND OBJECTIVE

6. Toimprovepatient’scompliance.
Thesedosageformsdesigntorapidly
disintegrateand/ordissolvetoreleasethe
drugassoonastheycomeincontactwith
saliva,thus
Obviatingtheneedforwaterduring
administration,
Anattributethatmakesthemhighly
attractiveforpediatricandgeriatric
patients.

7. FORMULATION REVIEW

8. TechniquesofMDTFormulation
Thefast-dissolvingpropertyoftheMDTsisattributed
toquickingressofwaterintotabletmatrixresulting
inrapiddisintegration.Hence,thebasicapproachesto
developMDTsinclude:
•Maximizingtheporousstructureofthetablet
matrix.
•Incorporatingtheappropriatedisintegrating
agent/agents.
•Usinghighlywater-solubleexcipientsinthe
formulation.

9. PATENTED TECHNOLOGY TABLETS
Zydis
Quicksolv
Lyoc
Flashtab
Orasolv
Durasolv
Wowtab
Ziplets
Advatab
Flashdose
Oraquick

10. Various manufacturing techniques for MDDDS include:
1. Lyophilization
2. Moulding
3. Direct Compression
4. Cotton Candy Process
5. Spray Drying
6. Sublimation
7. Mass Extrusion
8. Nanonization
9. Fast Dissolving Films

11. LITERATURE REVIEW

12. •Panigrahietal(2012)haveformulatedfastdissolvingtabletofgliclazidefor
rapidactionbydirectcompressionmethodandevaluatedforpost
compressionparameterlikehardness,disintegrationtime,weightvariation,
friability,wettingtime,waterabsorptionratioandmouthfeel.Themouthfeel
wasdonebytakinghumanvolunteersinapanelscalemethod.Different
formulationwaspreparedusingthesuperdisintegrantsinthreeindividual
concentrationi.e.(3%,5%,and10%).Theresultobtainedshowedthatat10%
concentrationsuperdisintegrantsshowedlessdisintegrationtimeandgood
hardness.Itwasconcludedthatformulationcontainingcrosspovidoneat10%
wasselectedtobethebestformulation.
•Rizwanullaetal(2011)havepreparedfastdissolvingtabletbyusingdirect
compressionmethodandevaluatedforhardness,friability,weightvariation,
waterabsorptionratio,dissolutionandassay.Andconcludedthatamongthe
fourgroups(B)containingAC-Di-Solemergedasthebestformulationand
showedmaximumdissolutionrate.

13. •Kumaretal(2010)havedevelopedoralfastdissolvingtabletsof
promethazineHClbydirectcompressionmethodusingcamphorassubliming
agentinthreeconcentrationsof2%,5%,&10%.Sodiumstarchglycolate,
crosscarmelloseandtulsion414areusedassuperdisintegrantsindifferent
ratio(5%,10%)andevaluatedevaluatedforweightvariation,hardness,
friability,drugcontent,disintegrationtime,wettingtimeandinvitro
dissolution.Theresultrevealedthattabletscontainingcamphorhadagood
dissolutionprofile.
•Ghorwadeetal(2011)havepreparedbysolventcastingmethodusing
HPMCasfilmbasewithdifferentconcentrationofsuperdisintegrantslike
microcrystallinecelluloseandcrospovidoneusingPEG400asplasticizerand
concludedthatthereleaseofdrugfromthefilmhasfollowedfirstorder
kinetics.Nochangeinthephysicalparameterinvitrodisintegrationtimeand
drugcontentofF
2.
Thedatademonstratedthat4%crospovidoneand10%
MCCwith4%HPMCasafilmbasewassuitablefordevelopingfast
dissolvingfilmofmontelukastsodium.

14. PLAN OF WORK

15. STAGE 1)
•REVIEW OF LITERATURE
•Survey
•Review of articles
•Review of old Resources
STAGE 2)
•PREFORMULATION STUDIES
•Solubility Profile of drug
•Melting Point of the drug
•Preparation of Standard Caliberationcurve
•Drug ExcipientCompatibility Studies

16. STAGE 3)
•FORMULATION AND OPTIMIZATION METHODS
•Zydis
•Quicksolv
•Lyoc
•Flashtab
•Orasolv
•Durasolv
•Wowtab
•Ziplets
•Advatab
•Flashdose
•Oraquick

17. STAGE 4)
•PHYSICAL PROPERTIES
•Weight variation test
•Surface ph determination
•Drug content uniformity
•Mechanical strength
•Particle size
•Solubility
STAGE 5) CHARACTERISATION
•Weight variation test
•Surface ph determination
•Drug content uniformity
•Friability
•Hardness test
•Water absorption test
•Porosity determination
•Effervescent test
•In-vitro and in-vivo disintegration test.
•In-vitro and in-vivo dissolution test.
•Acid neutralisationtest

18. EXPECTED OUTCOMES

19. Withcontinuedinnovationsinpharmaceutical
excipients,onecanexpecttheemergenceofmorenovel
technologiesforFDTsinthedaystocome.
Theseinnovationsmayinvolvemodifying
formulationcompositionandprocessingtoachievenew
performanceend-pointsorthemergerofnew
technologicaladvanceswithtraditionalpharmaceutical
processingtechniquesfortheproductionofnovel
mouthdissolvingdosageforms.
Itisreasonabletoexpectthatfuturetrendsin
innovationsofdrugdeliverysystemswillcontinueto
bringtogetherdifferenttechnologicaldisciplinesto
createnoveltechnologies.

20. REFERENCES

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