Gastrointestinal agents _ Acidifiers.ppt

MAKAUT/SEM 1/ PHARMACEUTICAL INORGANIC CHEMISTRY/ UNIT 3/GASTROINTESTINAL AGENTS_ACIDIFIERS

BY
KUNAL DATTA
ASSISTANT PROFESSOR
B.PHARM , M.PHARM
NETAJI SUBHAS CHANDRA BOSE INSTITUTE OF PHARMACY
CHAKDAHA , NADIA

1. PT 103 PHARMACEUTICAL INORGANIC
CHEMISTRY(THEORY)
KUNAL DATTA
UNIT III : Gastrointestinal Agents
Acidifiers

2. Acidifiers

3. •AcidifiersorAcidifyingReagentsarethe
drugswhichareabletoincreasetheacidity
temporarilyinGIT.
•InanotherwordsAcidifiersareinorganic
chemicalsthateitherproduceorbecome
acid.
•Thesechemicalsincreasethelevelofgastric
acidinthestomachwheningested,thus
decreasingthestomachpH.
•Systemicacidifiersgivenviainjection
reducesthealkaliaccumulationinthebody
andusefulinreducingmetabolicalkalosis.

4. Types Of Acidifiers
Mainlytherearethreetypesofacidifiers:
1.GastricAcidifiers
2.UrinaryAcidifiers
3.SystemicAcidifiers

5. Gastric Acidifiers
•UsedincontrollingacidicpHinstomach.

6. Urinary Acidifiers
•UsedincontrollingacidicpHinurine.

7. Systemic Acidifiers
•UsedincontrollingacidicpHofallpartsofthe
body.

8. Dilute Hydrochloric acid

9. Preparation
•Itispreparedbyadding274gofconcentratedHCl
slowlyinto726gofpurifiedwater.
•Pungentodour
•Colorlessliquid
•Fuming
•Itreactswithmetalsandreleasehydrogengas.

10. Assay
•Acidbasetitrationreaction.
•Anaccurateamountabout4gofHCldissolvedin
40mlofwaterandtitratedagainst1NNaOH
usingmethylorangeasanindicator.
•Neutralizationreactiontakesplace.
•Methylorangeisyellowinalkalimediumandit
changestoredinacidmedium.

11. Uses
•Itisusedasanacidifier.

12. Storage
•Itisstoredinwellclosedcontainers.

13. Dose
•0.6to8ml

14. Ammonium Chloride

15. Preparation
•Ammoniumchlorideispreparedbycommercial
method.
•NeutralizationofAmmoniawithHClyields
AmmoniumChloride.
•Thepurificationisdonebysublimationprocess.

16. Properties
•Appearance:Whitesolid,hygroscopic
•Odor:Odourless
•Taste:Coolingsaline
•Density:1.5274g/cm3
•Meltingpoint:338degreeC(decomposes,sublimes)
•Solubility:freesolubleinwaterandglycerol,
Sparinglysolubleinalcohol.

17. Assay
•Acidbasetitrationreaction.
•Dissolve1.000gofAmmoniumchloridein20mlof
waterandaddamixtureof5mlofformaldehyde
solution,withfewdropsofphenolphthaleinsolution.
After1minto2min,titrateslowlywith1Msodium
hydroxide.
•Neutralizationreactiontakesplace.
•Endpointistheappearanceofpalepermanentpink
color.

18. Assay
•Indicatoriscolorlessinacidandpinkinalkaline
medium.

19. Uses
Ammoniumchlorideisusedasanexpectorantincough
medicine.
Ammoniumsaltsareanirritanttothegastricmucosaand
mayinducenauseaandvomiting.
Ammoniumchlorideisusedasasystemicacidifyingagent
intreatmentofseveremetabolicalkalosis.
Themainapplicationofammoniumchlorideisasa
nitrogensourceinfertilizers.
Ammoniumchlorideisusedasafluxinpreparingmetals
tobetincoated,galvanizedorsoldered.

20. Storage
•Itisstoredinhighlyclosed
containers.

21. Dose
1to2gm(Assystemicacidifier)
0.3to0.5gm(Expectorant)

22. THANK YOU