GLYCOPYRROLATE.pptx

This PPtx contains information regarding glycopyrrolate

1. Glycopyrrolate BY: Dr.Tahir ENT

2. So Whats Used For? It is synthetic anticholinergic drug. Used to reduce Salivary, tracheobronchial and pharyngeal secretions & reduce the volume of free gastric acid. In GA: Conjunction with neostigmine, (a neuromuscular blocking reversal agent, to prevent neostigmine’s muscarinic effects).

3. Mechanism Of Action Glycopyrrolate competitively blocks acetylcholine, at muscarinic receptors M1, M2, & M3 Resulting in Parasympatholytic effect and allows for dominant Sympathetic activity. It does not cross the BBB, (unlike Atropine) therefore does not exert CNS effects .

4. Available Forms..! Inj. Pyrolate IV (0.2mg/1ml) Available Form in Pakistan Tabs: 1, 1.5, 2 mg Oral Solution ( Cuvposa ) :1mg/5ml

5. Dosage…! IV/IM: ADULT: 0.1-0.2mg/dose TID-QID MAX. DOSE: 0.2mg/dose OR 0.8mg/24hr ORAL: ADULT: 1-2mg/dose BID-TID

6. Onset Of Action & Duration of effect Onset Of Action: IV: 1 min. IM/SC: 15-30 min. Oral: 1 hr Duration of antisialagogue effect; IV/IM/SC: 7 hr Oral: 8-12 hr

7. Metabolism Undergoes little metabolism 80% excreted unchanged via kidney and liver.

8. Use with Caution In hepatic and renal disease Ulcerative colitis Asthma Glaucoma Urinary Retention

9. Side Effects Atropine Like Side effects Reduces the body’s sweating ability It can cause fever, flushing and heat stroke in hot environment. Tachycardia Dry Mouth……40% & Difficulty in urinating Headaches & Constipation It induces drowsiness or blurred vision an effect exacerbated by the consumption of alcohol .

10. ThankYou …..!