GUGGULU PRAYOGA

COMMONLY USED GUGGULU FORMULATIONS AND THERE USES. HOPE IT PROVIDES INSIGHT OF GUGGULU IN AYURVEDA

1. G u g g u l u prayoga in MSK dISEASES KAMAL KISHORE [email protected] 2 ND YR P.G. SCHOLAR DEPT. OF P.G. STUDIES IN KAYACHIKITSA SKAMCH&RC BANGALORE

2. DEFINITION Guggulu is an exudate ( Niryasa ) obtained from the plant Commiphora mukul . 1

3. 2 GUGGULU DISTRIBUTION

4. TYPES There are five different varieties of Guggulu described in the texts. However, two of the varieties, namely Mahishaka And Kanaka Guggulu are usually preferred for medicinal preparations. A. Mahishaksha B. Mahaneel C. Kumuda D. Padma E. Hiranya /Kanaka 3

5. Mahiksha Guggulu is DARK GREENISH BROWN Kanaka Guggulu is YELLOWISH BROWN in colour . Rasa : TIKTA KATU Guna : Old - LAGHU, RUKSHA, TIKSHNA, VISHADA, SUKSHMA, SARA New – SNIGDHA, PICHHILA Veerya : USHNA Vipaka : KATU Nava Guggulu – Fresh Guggulu  (before one year) is Bruhmana – nutritious, improves body strength & Vrushya . Purana Guggulu –  Guggulu older than a year – is Lekhana . It is tridoshhara . 4 PHARMACOLOGICAL PROPERTIES

6. CHARAKA SAMHITA “ Sangya Sthapana Maha Kashaya ” ( Ch.Su . 4/48) “ Kashaya Skandha ” (Ch.Vi.8/144) In diseases like Urustambha , Vatarakta etc SUSHRUTA SAMHITA Guggulu in the list of seven most important drugs for the treatment of Sthaulya ( Su.Su . 15/32) , ( Su.Chi . 5/35) Vidradhi (Chi. 17/32), Shotha ( Su.Chi . 23/12), Gulma ( Su.Utt . 42/63) etc. ASHTANGA Medoroga and Vatavikaras . Kushtha , Prameha , Shopha etc. 5 GUGGULU IN AYURVEDA

7. HARITA SAMHITA Maharishi Harita has elaborated guggulu in a separate chapter titled “Guggulu Kalpa ” (5th chap./6-8). BHELA SAMHITA Dhoomrapan of guggulu and vrana ropana propertY . SHARANGADHARA SAMHITA Various formulations are mentioned e.g. kanchnara guggulu BHAISYAJYA RATNAVALI, BHAV PRAKASH DHANVANTARI NIGHANTU, MADANPAL NIGHANTU, RAJ NIGHANTU, BHAVAPRAKASHA NIGHANTU ETC. 6 GUGGULU IN AYURVEDA

8. Many Acharyas have quoted Medohara property of guggulu , the references are- Sushruta Su. 15/32, Chi. 5/40-42 Ashtanga Sangraha Su. 12/74-76, Su. 13/2 Ashtanga Hridaya Su. 14/13, Chi. 21/50 Dhanvantari Nighantu Chandanadi Varga 128-131 Bhavaprakash Nighantu Karpuradi Varga 30-41 Kaidev Nighantu Aushadhi Varga 1015 – 1018 Dravyaguna Vigyana 1st chap. Vedanasthapana 7 MEDOHARA PROPERTIES

9. SHODHANA Process of shodhana (1) Sand stone, glass etc. are first removed. (2) It is then broken into small pieces. (3) It is thereafter bundled in a piece of the cloth and boiled in Dola Yantra containing any one of the following fluids. ( a) Gomutra ( b) Triphala kashaya . ( c) Vasapatra Kashaya . ( d) Vasapatra Svarasa . ( e) Nirgundi patra Svarasa with Haridra Choorna (f) Dugdha . 8

10. The boiling is continued till the Guggulu becomes a soft mass. It is then taken out of the cloth and spread over a smooth wooden board smeared with ghee or oil . By pressing with fingers the sand and other remaining foreign impurities are removed. It is taken out and again fried with ghee and ground in a stone mortar ( khalva ). This is called Shodhita Guggulu. Guggulu, which BURNS in fire, MELTS in sunlight and gives MILKY EMULSION when dissolved in lukewarm water. It should be free from foul smell and GOLDEN COLOR are said to be the Prasashta guggulu lakshanas (properties). 9

11. CHARACTERISTICS Shodhita Guggulu is soft, waxy and brown in colour . General dose is 3GM PER DAY or 1-2 gulika twice/thrice per day in divided doses. Possible side effects could be heartburn, acidity, burning sensation in abdomen, allergic reaction (rare). Common apathya are AMLA, KATU, TIKSHAN AHARAS, AJIRNA, VYAYAMA, SHRAMA, ATAPA, MADYA ETC. 10

12. COMMON PREPARATIONS 1 KANCHANARA GUGGULU SHARANGDHARA SAMHITA MADHYAMA KHANDA ADHYAYA 7 2 KAISHORA GUGGULU BHAISYAJYARATNAVALI VATARAKTA ADHIKARA 3 GOKURSHADI GUGGULU SHARANGDHARA SAMHITA MADHYAMA KHANDA ADHYAYA 7 4 TRAYODASHANGA GUGGULU BHAISYAJYARATNAVALI VATARAKTA ADHIKARA 5 TRIPHALA GUGGULU SHARANGDHARA SAMHITA MADHYAMA KHANDA ADHYAYA 7 6 MAHA YOGARAJA GUGGULU SHARANGDHARA SAMHITA MADHYAMA KHANDA ADHYAYA 7 11

13. 7 YOGARAJA GUGGULU BHAISYAJYARATNAVALI AAMAVATA ADHIKARA 8 LAKSHA GUGGULU BHAISYAJYARATNAVALI BHAGANDARA ADHIKARA 9 VYOSHADI GUGGULU ASHTANGA HRIDYA CHIKITSA STHANA 10 VATARI GUGGULU BHAISYAJYARATNAVALI AAMAVATA ADHIKARA 11 SAPTAVIMSHATIKA GUGGULU BHAISYAJYARATNAVALI BHAGANDARA ADHIKARA 12 SIMHANANDA GUGGULU BHAISYAJYARATNAVALI AAMAVATA ADHIKARA 13 AMRITA GUGGULU BHAISYAJYA RATNAVALI 12

14. 14 PANCHAMRITA LOHA GUGGULU BHAISYAJYA RATNAVALI MASTISHKA ROGADHIKARA 15 PANCHATIKTA GHRITA GUGGULU RASATANTRA SAARA 16 PUNARNAVA GUGGULU BHAISYAJYA RATNAVALI VAATRAKTA ADHIKARA SOPHA CHIKITSA 17 RASNADI GUGGULU BHAISYAJYA RATNAVALI VAAT VYADHI ADHIKARA CHAKRADATTA 18 SHIVA GUGGULU BHAISYAJYA RATNAVALI AMAVATA ADHIKARA 13

15. KANCHANARA GUGGULU 14

16. GUGGULU KANCHANARA TWAK TRIFLA TRIKATU VARUNA TRIJATA 0.5 PART 0.25 PART 0.15 PART 0.075 PART ( each ) 0.05 PART 0.002 PART COMPOSITION Fine powders of all drugs are added to the guggulu and pounded well. Ghrita is added to the extent required when pounded to form a mass. 15

17. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS KASHAYA TIKTA KATU LAGHU RUKSHA SUKSHMA USHNA VIRYA TRIDOSHA HARA Esp. KAPHA HARA MAMSA MEDO (CHEDANA & LEKHANA) DIPANA PACHANA (DHATWAGNI LEVEL) ANTINFLAMMATORY ANTI CANCEROUS LYMPHATIC REGULATOR SHOOLA HARA JANTUGHANA VRANA SHODHANA MAMSA CHEDANA GRANTHI VILAYANA 16

18. IMPORTANT THERAPEUTIC USES GALAGANDA APACHI ARBUDA GRANTHI VRANA GULMA KUSHTHA BHAGANDARA TONSILITIS HYPOTHYROIDISM NASAL POLYPS INT. & EXT. CYST OBESITY GOITRE TUMOUR LYMPH ADENOPATHY PCOS BPH OBESITY ASS. JOINT PAINS SYPHILIS SINUSITIS WARTS 17

19. ANUPANA VARUNADI KASHAYA HYPOTHYROIDISM,GOITRE, TUMOUR, ADENOMA, POLYPS etc VYAGHRADI KASHAYA GUGGULUTIKTAM KASHAYA DASHMOOLAKATUTRAYAM KASHYAM CH. SINUSITIS USHNA JALA PATHYA KWATHAM KHADIRA SARA KWATHA 18

20. KAISHORE GUGGULU 19

21. GUGGULU TRIKATU AMRITA TRIFLA VIDANGA TRIVRIT/DANTI TRIJATA 0.8 PART 0.075 PART 0.05 PART 0.025 PART ( each ) 0.025 PART ( each ) 0.01 PART 0.001 PART COMPOSITION Kashaya of trifla (0.8 part) guduchi ((1.5 part) is prepared. Guggulu is added to the filtered Kashya and boiled in an iron vessel. When the Kashya becomes concentrated, fine powder of remaining drug is added and stirred well. Ghrita is added last and mixed well to form a mass. 20

22. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS TIKTA KASHAYA KATU USHNA VIRYA PRABHAV KARMA TRIDOSHA HARA RAKT PRASADANA MEDO HARA (RATK GATA DOSHA PACHANA) ANTINFLAMMATORY IMMUNOMODULATOR Slightly laxative IMPROVES MICRO CIRCULATION MALANULOMNA VIBANDHHARA SOOLA PRASAMANA JANTUGHANA KAISHORE GUGGULU IS AMRITA VISHESHA SHODHITA GUGGULU KALPANA AND HAS BEST RESULTS IN PITTA ANUBANDHA OR PK ANUBANDHA VAATA ROGA / VAATA RAKTA. ALSO ACTS AS RAKT SUDDHIKARA RAKTMARGA VISHODHANA,RAKT GATA DOSH PACHANA, JEERNA RAKTA PRADOSHAJA VYADHIS AND AAMA VISHA JANYA VYADHIS. 21

23. IMPORTANT THERAPEUTIC USES VAATSHONITA MANDAGNI VIBHANDA PRAMEHA PIDIKA JARA DOSHA SWAYATHU GULMA SARVA KUSTHA PANDU NETRA ROGA JARA DOSHA SRAVI VRANA INFLAMMATORY ARTHRITIS esp. GOUT EYE DISEASES INFLAMMATION OF NAIL BED (PARONYCHIA) PSORIATIC ARTHRITIS JUVENILE ARTHRITIS BURSITIS OA AVASCULAR DISEASES SKIN DISEASES ULCERS 22

24. ANUPANA VARUNADI KASHAYA GULMA GUGGULUTIKTAM KASHAYA DASHMOOLAKATUTRAYAM KASHYAM AMAVATAAI KASHAYAM RASNAERANDADI KASHAYAM ARTHRITIS SPECTRUM BURSITIS AVASCULAR JOINT DISEASES VASADI KASHYAM NETRA ROGA KHADIRADI KASHYAM SKIN DISEASES YUSHA, USHNA JALA, SUGHANDHA JALA, KSHIRA, MAHAMANJISTHADI KWATHA Arunshika 23

25. GOKURSHADI GUGGULU 24

26. GUGGULU TRIKATU TRIFLA MUSTA 0.5 PART 0.2 PART 0.2 PART 0.07 PART ( each ) COMPOSITION Kashaya Of Gokshura (2parts) is prepared. Guggulu is added to the filtered Kashaya Which is boiled again to rasakriya p aka . Fine powder of remaining drugs is added and mixed well. 25

27. PHARMACOLOGY GUNA DOSHA DUSHYA PHARMACODYNAMICS MADHUR TIKTA KATU SHEETOSHNA VIRYA TRIDOSHA HARA MEDO HARA DIURETIC ANTINFLAMMATORY ANTI HTNSIVE ANTI CANCEROUS ANTI VIRAL NEPHRO PROTECTIVE INC. VIGOUR AND VITALITY STREGTHEN KIDNEY & PROSTRATE 26

28. IMPORTANT THERAPEUTIC USES MUTRAKRICHRA PRAMEHA MOOTRAGHATA VAATRAKTA ASHMARI PRADRA SHUKRA DOSHA VATA ROGA UTI OLIGOURIA GOUT REACTIVE ARTHRITIS GEN. & LOCALIZED OEDEMA BPH, CRF LEUCORRHOEA GONORRHOEA BED WETTING (NOCTURNAL ENURESIS) HAEMATUREA GB & UB DISORDERS CHOLELITHIASIS INFERTILITY OEDEMA DUE TO RENAL DISEASES PROSTATITIS, CYSTITIS URINARY OBSTRUCTION 27

29. ANUPANA VARUNADI KASHAYA PUNARNAVA SAVA PUNARNAVA KASHAYAM CHANDRAPRABHA VATI MUSTA KWATHA PASHANBHEDA KWATHA USHIRA KWATHA 28

30. TRAYODASHANGA GUGGULU AABHA GUGGULU 29

31. GUGGULU AABHA/ BABOOL AMRITA, ASWAGANDHA,SHATAVARI,HAPUSHA, GOKSHURA, RASNA, SHATI,YAVANI, SUNTHI, SARPI,VRIDHDARU, SATAVAHA 12 PART 1 PART 1 PART COMPOSITION Fine powder of all drugs is added to the guggulu and pounded well. Gh¤ta , in small quatities , is added at the time of pounding till the whole thing becomes as soft mass. 30

32. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS TIKTA KASHAYA KATU MADHURA RUKSHA-SNIGDHA USHNA VIRYA PRABHAV KARMA TRIDOSHA HARA Esp. VAATA SHAMANA ASTHI & MAJJA GAT VAATA ASTHI DHATU DEEPANA ANTINFLAMMATORY SANDHI SOPHA HARA SANDHI GRAHA GHANA SHOOLA PRASHMANA BHAGNA SANDHANA TRYODASHANG GUGGULU IS BEST FOR SANDHIGAT/MAJJAGATA/SNAYUGATA VAATA ROGA ASTHIBHAGNA DHATUKSHYAJANYA VAAT VIKARAS KATI KSHERU VAAT VIKARAS DOSE = 1 TAB B.D. 31

33. IMPORTANT THERAPEUTIC USES ASTHI SOUSHIRYA ARDITA KATIGRAHA/SHOOLA BAHU/PRISHTA SHOOLA ASTHIBHAGNA KHANJA VAATA HANUGRAHA JANUGRAHA PADAGRAHA GRIDHRASI ASTHI/ SNAYU/ MAJJA GAT VAATA HRIDGRAHA LUMBAR SPONDYLOSIS DEGENRATIVE ARTHRITIS LUMBO SACRAL STRAIN SCIATICA FRACTURE RECOVERY OSTEOPOROSIS BONE MARROW DISORDERS LOCK JAW HEART FAILURE 32

34. ANUPANA SURA DHANYA YUSHA USHNA JALA KSHIRA MAMSA RASA SHACHARADI KASHYAM RASNA SAPTAKAM KS 33

35. TRIPHALA GUGGULU 34

36. GUGGULU TRIFALA PIPPALI 0.5 PART 0.3 PART 0.1PART COMPOSITION Fine powder of all drugs is added to the guggulu and pounded well. 35

37. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS TIKTA KASHAYA KATU LAGHU RUKSHA SUKSHMA USHNA VIRYA TRIDOSHA HARA Esp. KAPHAVAATA SHAMANA MEDO HARA MALANULOMNA MEDO AGNI DEPANA ANTINFLAMMATORY LEKHANA VRANA SHODHANA/ROPANA SOPHA HARA PAKA HARA PUTI GANDHA HARA VISHA HARA HYPOLIPIDAEMIC ANTIBIOTIC DETOXIFYING ANTI OXIDANT 36

38. IMPORTANT THERAPEUTIC USES BHAGANDARA GULMA SHOPHA/SHOTHA ARSAS VIDRADHI NAADI VRANA GANDAMALA VRANA KOTHA GRANTHI PILES/HAEMORRHOIDS FISTULA IN ANO INT. ABCESS INTERNAL ORGAN INFLAMMATION SKIN ERUPTIONS OBESITY FATTY LIVER DIABETIC GANGERENE NON HEALING ULCER DIABETIC WOUND PATHOLOGICAL SINUSES VARICOSE VEINS BOILS 37

39. ANUPANA GUGULU TIKTAM KASHAYAM /GHRITAM NON HEALING WOUND MAHATIKTAM KASHAYAM, TIKTAM KASHAYAM ABCESS GHRITA YUKT BHOJANA 38

40. MAHA YOGARAJA GUGGULU 39

41. GUGGULU TRIFALA RAS AUSHADHIS VANGA, RAJATA, NAGA, LOHA, ABHRAK, MANDOORA, PARADA 0.3 PART 0.2 PART 0.07PART each COMPOSITION The fine powder of all the drugs, guggulu and the bhasmas are mixed and pounded well with Ghrita . Other drugs are added in small quantity like chaturjaat , jeerak dwaya , vidanga , ativisha , vacha , moorva etc 40

42. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS TIKTA KASHAYA KATU LAGHU RUKSHA SUKSHMA USHNA VIRYA TRIDOSHA HARA Esp. VK SHAMANA ASTHI MAJJA PACHANA DEPANA (JATHRAGNI & DHATWAGNI) ANTINFLAMMATORY ANALGESIC ANTISPASMODIC MUSCLE RELAXANT MEDOHARA VRISHYA BALYA RASAYANA SANDHI ASTHI MAJJAGAT VAATA RASAYANA DHATUPOSHAKA NAADI BALYA VANDHYATA HARA ANTI OXIDANT 41

43. IMPORTANT THERAPEUTIC USES AAMVAATA AARTVASHOOLA ANAARTAVA CH. VAAT VIKARAS VAATIK PRAMEHA HRIDGRAHA UDARA PANDU VANDHYATA VATRAKTA GRAHANI ARSAS KUSTHA KSHAYA APASMAAR DEGENRATIVE ARTHROPATHY NEUROPATHY NERVOUS DEBILITY MENSTRUAL DISORDERS EPILEPSY UDAVARTA GULMA NABHI SHOOLA RAJA DOSHA SHUKRA DOSHA DAURBALYA 42

44. ANUPANA RASNADI KS VAATA ROGA KAKOLYADI KS PAITIIKA ROGA ARAGWADADI KS KAPHAJA ROGA/ KAPHANUBANDHA VATA ROGA TRIFLA KW 43

45. YOGARAJA GUGGULU 44

46. GUGGULU KASTHA AUSHADHIS Chitraka , pipalamoola , jiraka , vidanga , saindhava , ajmoda , trikatu , trifla etc 0.5 PART 0.5 PART (total) COMPOSITION Fine powder of all drugs is added to guggulu and pounded well. Ghrita is added in small quantities while pounding till the whole thing becomes a soft mass 45

47. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS TIKTA KASHAYA KATU LAGHU RUKSHA SUKSHMA USHNA VIRYA TRIDOSHA HARA Esp. VK SHAMANA ASTHI MAJJA GAT VAATA PACHANA DEPANA (JATHRAGNI & DHATWAGNI) AAMPACHANA ANTINFLAMMATORY ANALGESIC ANTIARTHRITIC ANTISPASMODIC MUSCLE RELAXANT MEDOHARA VRISHYA BALYA RASAYANA SANDHI ASTHI MAJJAGAT VAATA RASAYANA DHATUPOSHAKA NAADI BALYA VANDHYATA HARA ANTI OXIDANT 46

48. IMPORTANT THERAPEUTIC USES AAMVAATA AADHYAVAAT PLIHA ROGA ASTHI SANDHI MAJJAGAT VAATA PADA GRAHA KROSHTUKA KARNA GRHA/SHOOLA SHIRA SHOOLA SOPHA ACUTE OA INF. ARTHRITIS DEGENRATIVE ARTHROPATHY HYPERLIPIDEMIA LUMBAGO MUSCLE SPASM 47

49. ANUPANA RASNADI KS MAHARASNADI KS GUGGULUTIKTAM KS AAMVATARI KS RASNASAPTAKAM KS YOGRAJ GUGGULU IS ONE OF THE MOST FAMOUS MEDICINE USED. IT PROVIDES BEST RESULTS IN KAPHANUBANDHA VAAT ROGA, SAAMAVASTHA OF SANDHIGATA VAATA SROTORODHA JANYA VAATA VIKARA VAATARAKTA IT HAS WHOLE BODY ACTION ESP. IN SANDHI ROGAS. 48

50. MAHAYOGRAJA GUGGULU VS YOGRAJA GUGGULU MAHAYOGRAJA GUGGULU YOGRAJA GUGGULU GUGGULU IS 0.3 PART CONTAINS RAS AUSHADHIS RASAYNA/VRISHYA PROPERTY IS MORE BEST RESULTS IN JEERNA AMAAVASTHA/NIRAMA AVASTHA & DHATUKSHAYA JANYA VAAT ROGAS GUGGULU IS 0.5 PART ONLY KASTHA AUSHADHIS CONSIDERED AS LESS SUPERIOR WORKS BETTER FOR SAAMAVASTHA AND SROTORODHA JANYA VAAT VIKARAS 49

51. LAKSHA GUGGULU 50

52. GUGGULU LAKSHA, ASTHISHRINKHALA, ARJUNA, ASWAGANDHA,NAGBALA 0.5 PART 0.5 PART (total) COMPOSITION Fine powder of all drugs is added to guggulu and pounded well. Ghrita is added in small quantities while pounding till the whole thing becomes a soft mass 51

53. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS TIKTA KASHAYA GURU RUKSHA USHNA VIRYA TRIDOSHA HARA ASTHI PACHANA (DHATU LEVEL) ANTINFLAMMATORY ANALGESIC FRACTURE HEALING ASTHI SANDHANKARA 52

54. IMPORTANT THERAPEUTIC USES BHAGNA ASTHI RUJA RAKTPITTA SANDHI SHOOLA ASTHI SOUSHIRYA OSTEOPOROSIS RICKETS FRACTURES LIGAMENT INJURIES OSTEOARTHRITIS VERTEBRAL FRACTURES 53

55. ANUPANA WARM WATER 54

56. VYOSHADI GUGGULU NAVAKA GUGGULU MEDOHARA GUGGULU 55

57. GUGGULU TRIKATU TRIFLA TRIMADA 0.5 PART 0.5 PART (TOGETHER) COMPOSITION Fine powder of all drugs is added to guggulu and pounded well. Ghrita is added in small quantities while pounding till the whole thing becomes a soft mass 56

58. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS KATU TIKTA KASHAYA LAGHU SUKSHMA RUKSHA TIKSHANA USHNA VIRYA TRIDOSHA HARA ESP. KV SHAMANA MEDO HARA DEEPANA PACHANA AAM PACHANA ANTINFLAMMATORY ANTIARTHRITIC ANTI ATHEROSCLEROTIC ANTI LIPIDEMIC DURMEDOHARA IT CAN DIGEST ALL THE AMA PRODUCTS IN KOSTHA & DHATU LEVEL. IT IS CONSIDERED BEST FOR CHOLESTEROL PROBLEMS. IT IS NOT RECOMMENDED IN KEVALA PITTA / RAKTA CONDITIONS. 57

59. IMPORTANT THERAPEUTIC USES AAMVAATA URUSTAMBHA STHOLYA SHLIPADA HYPERCHOLESTEROLEMIA DYSLIPIDAEMIA HELIMENTHIASIS OBESITY ASS. JOINT PAIN MYALGIA 58

60. ANUPANA USHNA JALA NAVAGA GUGGULU/VYOSHADI GUGGULU VS NAVAYASA LAUHA 1.) NAVAGA GUGGULU HAS GUGGULU 0.5 PARTS WHEREAS NAVAYAS LAUHA HAS AYO RAJA/LOHA BHASMA AS 0.5 PARTS. 2.) NAVAGA GUGGULU HAS EXCELLENT STHOLAYA HARA PROPERTY WHEREAS NAVAYAS LAUHA HAS EXCELLENT PANDU SHAMANA PROPERTY. 3.) NAVAGA GUGGULU HAS NO ROLE IN PANDU ROGA WHEREAS NAVAYAS LAUHA IS USED IN BOTH DISEASES e.g. STHOLAYA ASS. ANAEMIA. 59

61. VATARI GUGGULU 60

62. GUGGULU ERANDA TAILA TRIFLA GANDHAKA 1/6 PART 1/6 PART 1/6 PART (EACH) 1/6 PART COMPOSITION Guggulu is made soft by adding Eranda Taila . Powder of other drugs are added and mixed well. 61

63. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS KATU TIKTA MADHURA KASHAYA SNIGDHA RUKSHA USHNA VIRYA TRIDOSHA HARA ESP. VK SHAMANA MEDO HARA DEEPANA PACHANA AAM PACHANA ANTINFLAMMATORY ANTIARTHRITIC MALANULOMNA MILD LAXATIVE IT CAN DIGEST ALL THE AMA PRODUCTS IN KOSTHA & DHATU LEVEL. IT IS CONSIDERED BEST FOR CHOLESTEROL PROBLEMS. IT IS NOT RECOMMENDED IN KEVALA PITTA / RAKTA CONDITIONS. 62

64. IMPORTANT THERAPEUTIC USES AAMVAATA GRIDHRASI KHANJA PANGU SASHOPHA VAATRAKTA SNAYUGATA VATA SANDHIGATA VAATA KROSTHRUKA SHIRSHAKA SYNOVITIS RA PARAPLEGIA BURNING PAIN INFLAMMATION 63

65. ANUPANA USHNA JALA 64

66. SAPTAVISHATI GUGGULU 65

67. GUGGULU TRIFLA,TRIKATU, TRIMADA, AMRITA, HARIDRA DWAYA, SHATI SAINDHAVA, SARJ KSHARA ETC. 54 PART 1 PART EACH COMPOSITION Fine powder of all drugs is added to guggulu and pounded well. Ghrita is added in small quantities while pounding till the whole thing becomes a soft mass 66

68. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS KATU TIKTA LAVANA KASHAYA LAGHU TEEKSHANA SUKSHMA RUKSHA USHNA VIRYA KV SHAMANA MEDO HARA DEEPANA PACHANA AAM PACHANA ANTINFLAMMATORY ANTIARTHRITIC APANA SAMANA AND UDANA VATAANULOMNA, JANTUGHANA KRIMIGHANA ARSHOGHANA ANTRAVRIDDHI HARA IT HAS PROPERTIES 67

69. IMPORTANT THERAPEUTIC USES KASA SWASA SOPHA ARSHA BHAGANDARA PARSHWASHOOLA KUKSHI/VASTI/GUDA RUJA ASHMARI MOOTRAKRICHRA AANTRAVRIDDHI KRIMI NAADI VRANA JWARA UDARA SHLIPADA HYPERLIPIDEMIA INTERCOSTAL MYALGIA PILONIDAL SINUS FISSURE WORMS FILIARISIS 68

70. ANUPANA MADHU 69

71. SIMHANANDA GUGGULU 70

72. ERANDA TAILA TRIFLA KASHAYA GUGGULU 0.4 PART 0.3PART 0.2PART COMPOSITION Kashaya of triphala is prepared in an iron vessel, Eranda Taila is added to the Kashaya and boiled. When the liquid is concentrated guggulu are added and mixed well 71

73. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS KATU TIKTA MADHURA KASHAYA LAGHU RUKSHA SUKSHMA USHNA VIRYA KAPHA HARA ESP. VK SHAMANA MEDO HARA DEEPANA PACHANA DHATUGATAAMA PACHANA ANTINFLAMMATORY ANTIARTHRITIC MALANULOMNA VIRECHANA LEKHANA BALYA , RASYANA IT CAN DIGEST ALL THE AMA PRODUCTS IN KOSTHA & DHATU LEVEL. IT IS CONSIDERED BEST FOR CHOLESTEROL PROBLEMS. IT IS NOT RECOMMENDED IN KEVALA PITTA / RAKTA CONDITIONS. 72

74. IMPORTANT THERAPEUTIC USES AAMVAATA SANDHIVAATA KATIGRAHA PLIHA ROGA MEDO ROGA ARSHA SANDHI SOPHA SANDHI GRAHA SWASH KAAS VISHAMA JWARA PANDU PRAMEHA KUSTHA KSHAYA VAATRAKTA GULMA JARA PALITYA RA OA ASTHMA OBESITY DYSLIPIDAEMIA GOUT ANAEMIA 73

75. ANUPANA USHNA JALA SIMHNANDA GUGGULU HAS EXCELLENT RESULTS IN MARGAVRODHA JANYA VAAT VYADHIS AND ALSO EFFECTIVE FOR VAAT ROGAS WITH VIBANDHA. IT HAS MAINLY ACTION ON SHAKHA AND DHATU LEVEL.THIS MEDICINE GRADUALLY DIGESTS AAMA AND SLOWLY EXPELS IT OUT TOO. 74

76. BHAVA PRAKASHA BHAISYAJYA RATNAVALI in MEDOROGA ADHIKARA AMRITADI GUGGULU 75

77. COMPOSITION GUGGULU AMRITA TRIFLA, TRIKATU, DANTI , VIDANGA 32PART 1 PART 1 PART (EACH) 76

78. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS TIKTA KASHAYA RUKSHA USHNA VIRYA TRIDOSH HARA ESP. KP SHAMANA RASA RAKTA MEDO PRASADANA DEEPANA ANTINFLAMMATORY ANTIARTHRITIC MALANULOMNA VRAN ROPANA SOPHA HARA PAAKA HARA SRAVA HARA 77

79. IMPORTANT THERAPEUTIC USES VATARAKTA KUSTHA PRAMEHA SWAYATHU PAMA VICHARCHIKA MANDALA KUSTHA SKIN DISEASES ABSCESS PILES PSORIATIC ARTHRITIS GOUT 78

80. ANUPANA NIMBADI KS ABCESS VARUNADI KS OBESITY GUGGULUTIKTAM KS FISTULA AMRITA GUGGULU IS EFFECTIVE FOR PITTANUBANDHA KUSTHA, SANTARPANA JANYA KUSTHA SRAVI KUSTHA VAATRAKTA. IT ALSO HAS PROPERTIES LIKE AMA HARA, ATISWEDA HARA, DOUGANDHYA HARA. 79

81. BHAISYAJYA RATNAVALI MASTISHKA ROGADHIKARA PANCHAMRIT LOHA GUGGULU 80

82. COMPOSITION GUGGULU LOHA BHASMA RASA, GANDHAKA,RAJAT,ABHRAK, MAKSHIKA KATU TAILA (MUSTARD OIL) 0.5 PART 0.2 PART 0.07 PARTS (EACH) QS DOSE: 125-250MG 1-3 TIME/DAY 81

83. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS RUKSHA USHNA VIRYA PRABHAVA AVARAN VAAT HARA RAKTA PRASADANA NADI BALYA RASAYANA SHOOLA HARA STAMBHA HARA KAMP HARA 82

84. IMPORTANT THERAPEUTIC USES MASHTISHKA ROGA SNAYUGATA VAATA VAATAVYADHI APABAHUKA MAJJAKSHAYA CERVICAL SPONDYLOSIS HEADACHE HEAVINESS TREMORS TINGLING NUMBNESS 83

85. ANUPANA MAHARASNADI KS DASHMOOLARISHTA 84

86. RASATANTRA SAARA CHAKRADATT BHAISYAJYA RATNAVALI IN KUSTHA ADHIKAR PANCHTIKTA GHRITA GUGGULU 85

87. COMPOSITION GOGHRITA GUGGULU PATHA, VIDANGA, BHALLATAKA, ATIVISHA, CHITRAKA, VACHA, KATUKI ETC 0.2 PART 0.3 PART 0.02 PARTS (EACH) 86

88. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS TIKTA KATU KASHAYA RUKSHA USHNA VIRYA TRIDOSHA HARA ESP. VK SHAMANA RASA RAKTA PRASADANA ASTHI POSHAKA TWACHYA KUSTHGHANA KANDUGHANA SANDHI ASTHI MAJJAGAT VAAT SHAMANA 87

89. IMPORTANT THERAPEUTIC USES TWAK VIKARAS KUSTHA ARBUDA BHAGANDARA ARSAS VAATRAKTA SANDHI ASTHI MAJJA GATA VAATA CERVICAL SPONDYLOSIS LUMBAR SPONDYLOSIS PSORIATIC ARTHROPATHY GOUTY ARTHRITIS PAGETS DISEASE OA OSTEOPOROSIS DRY AND CRACKED SKIN AVN PSORIASIS DRY ECZEMA DANDRUFF Dandruff with itching 88

90. ANUPANA PANCHTIKTA KASHAYAM USHNA JALA ABHYAARISHTA Bhagandara Arsha Naadivrana 89

91. BHAISYAJYA RATNAVALI IN VAATRAKTA ADHIKARA & SOPHA CHIKITSA PUNARNAVA GUGGULU 90

92. COMPOSITION GUGGULU (GOMUTA BHAVITA AND SHODHITA) PUNARNAVA DEVDARU, HARITAKI GUDUCHI ERANDA TAILA 1/2 PART 1/8 PARTS (EACH) QS 91

93. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS LAGHU RUKSHA USHNA VIRYA KAPHA HARA MEDO HARA AAMA PACHANA DEEPANA SOPHA HARA PAAKA HARA KLEDA HARA MOOTRALA 92

94. IMPORTANT THERAPEUTIC USES VRIKKA VIKARA SANTARPANA JANYA VYADHIS MOOTRAKRICHHA VAATRAKTA VRIDDHI ROGA KAPHAJ SOPHA JALODARA PID UTI RENAL CALCULI JOINT PAIN WITH OEDEMA GOUT FIBROCYST HYPOTHYROIDISM INDUCED OBESITY CUSHING SYNDROME 93

95. ANUPANA PUNARNAVASAM AMRITARISHTA 94

96. BHAISYAJYA RATNAVALI IN VAAT VYADHI ADHIKARA RASNADI GUGGULU 95

97. COMPOSITION GUGGULU RASNA GOGHRITA 1/2 PART 1/2 PART QS 96

98. PHARMACOLOGY GUNA DOSHA DUSHYA AGNI PHARMACODYNAMICS TIKTA KATU LAGHU SUKSHAMA RUKSHA TIKSHANA USHNA VIRYA KAPHA ATA SHAMANA MEDO HARA ANTISPASMODIC ANTIINFLAMMATORY ANTIARTHRITIC ANALGESIC (MILD TO MODERATE) 97

99. IMPORTANT THERAPEUTIC USES GRIDHRASI SNAYUGATA VAATA AAMVAATA VAATRAKTA SANDHIGATA VAATA OA KNEE LBA WITH RADICULOPATHY SCIATICA RHEUMATIC PAIN 98

100. ANUPANA RASNADI KASHAYAM 99

101. SHIVA GUGGULU BHAISYAJYA RATNAVALI IN AMAVATA ADHIKARA 100

102. GUGGULU ERANDA TAILA TRIFLA KASHAYA GANDHAKA BHASMA RASNA VIDANGA MARICHA, PIPPALI, DEVDARU 0.4 PART 0.4 PART COMPOSITION 101

103. PHARMACOLOGY GUNA DOSHA DUSHYA PHARMACODYNAMICS KASHAYA TIKTA KATU SUKSHAMA RUKSHA U SHNA VIRYA VK SHAMANA ALANULOMANA ANTIARTHRITIC 102

104. IMPORTANT THERAPEUTIC USES AAMVAAT KATISHOOLA GRIDHRASI KROSHTUKA SIRSHA 103

105. ANUPANA USHNA JALA SIMHNANADA GUGGULU, VATARI GUGGULU &SHIVA GUGGULU ALL OF THESE HAS SIMILAR INGREDIENTS BUT QUANTITY OF INDIVIDUAL INGREDIENTS IS DIFFERENT. VATARI GUGGULU GUGGULU ERANDA TAILA TRIFLA GANDHAKA 1/6 PART 1/6 PART 1/6 PART (EACH) 1/6 PART SIMHANANDA GUGGULU ERANDA TAILA TRIFLA KASHAYA GUGGULU 0.4 PART 0.3PART 0.2PART SHIVA GUGGULU GUGGULU ERANDA TAILA TRIFLA KASHAYA GANDHAKA BHASMA RASNA,VIDANGA MARICHA, PIPPALI, DEVDARU 0.4 PART 0.4 PART 0.2 PARTS (TOTAL) 104

106. RESEARCH WORK ( 1) ANTIARTHRITIC activity : The oleoresin fraction showed significant antiarthritic activity in some studies. The acid fraction was also effective. ( 2 ) ANTIINFLAMMATORY activity : Guggulsterones also appear to reduce circulating levels of pro-inflammatory cytokines and markers such as IL-1b, IL-2, and TNF-a.[23] Guggulsterones are also able to reduce CycloOxygenase-2 (COX2) mRNA levels and suppress its TNFa mediated induction (activation).[ (3) ANTILIPDAEMIC and ANTI CHOLESTEROL activity was also recorded. (5) ANTI CANCEROUS effects through inhibition of P-glycoprotein efflux in breast cancer cells, guggulsterones have been implicated at increasing chemosensitivity to doxorubicin in drug-resistant breast cancer cells 105

107. CONCLUSION 106 Most commonly used Guggulu for MSK related problems are YOGRAJA GUGGULU Vaata Rogas TRYODASHANGA GUGGULU/ ABHA GUGGULU Asthimajjagat vaat , OA, Dhatukshaya janya vaat vikaras RASNADI GUGGULU Vaat vyadhi Gridhrasi LAKSHA GUGGULU Bhagna , Osteoporosis SIMHANADA GUGGULU,SIVA GUGGULU, VATARI GUGGULU Aamvaat Most commonly used Guggulu for ANO RECTAL related problems are TRIFLA GUGGULU Arsha , Bhagandara , Vrana SAPTVIMSHATI GUGGULU Arsha , Bhagandara,Kshaya , Kaas , swaas , Jwara

108. CONCLUSION 107 Most commonly used Guggulu for MEDO ROGA VYOSHADI GUGGULU/ NAVAKA GUGGULU/MEDOHARA GUGGULU Medo roga , anti atherosclerotic SHUDH GUGGULU Dyslipidaemias , Obesity, Metabolic syndromes Most commonly used Guggulu for URINARY DISORDERS GOKSHURADI GUGGULU UTI, Prameha , Mootra krichra , BPH, Ashmari PUNARNAVA GUGGULU Mootrakrichra / Vaatrakta / Sopha / Udara

109. 108 Most commonly used Guggulu for SKIN related problems are AMRITA GUGGULU Pama , Vicharchika , Sravi Kustha KAISHORE GUGGULU Sarva Kustha , Vaatrakta PANCHTIKTA GHRITA GUGGULU Kustha , Sandhi-asthi-majja gat vaata Most commonly used Guggulu as RASAYANA MAHAYOGRAJA GUGGULU Nadi balya , Dhatukshaya janya vaat vikara GOKSHURADI GUGGULU Vrishya PANCHAMRIT LOHA GUGGULU Daurbalya , Pandu CONCLUSION

110. 109 Most commonly used Guggulu for Glandular problems are KANCHNARA GUGGULU Goitre , Lymph adenopathy,BPH , PCOS, Ch.Sinusitis , Nasal Polyps, Cysts,Tumors CONCLUSION Some other uses of Guggulu HTN GOKSHURADI GUGGULU UDARA, SOPHA PUNARNAVADI GUGGULU TREMORS, HEADACHE PANCHAMRIT LOHA GUGGULU

111. Guggulu has its place and importance in Ayurveda just like Google in Internet. Guggulu given bhavna , shodhana with specific herbs make it more effective e.g 110 DISCUSSION AMRITA GUGGULU Bhavna with Guduchi & Trifla useful for Skin related diseases PUNARNAVA GUGGULU Bhavna with GOMUTRA Shodhana with GOMUTRA Useful in Udara , Sopha , Sotha , Mootra krichra PANCHTIKTA GHRIT GUGGULU Bhavna with NIMB TWAK KASHAYA, GUDUCHI SWARAS, VAASA SWARAS, PATOLA KS, KANTKARI KS. Shodhana with TRIPHALA Useful in Kustha Sandhi Asthi Majja gata vaata .

112. 111 DISCUSSION KANCHNAR GUGGULU Shodhana with TRIPHALA Gandmala TRIFLA GUGGULU Shodhana with TRIPHALA Arsh Stholaya KAISHORE GUGGULU Shodhana with AMRITA Vaatrakta , kustha SIMHNADA GUGGULU Shodhana with AMRITA Amavata & Margavarodhajanya Vatavyadhii PANCHTIKT GHRIT GUGGULU Shodhana with TRIPHALA Sarva kustha , Psoriasis

113. 112 DISCUSSION YOGRAJA GUGGULU Shodhana with DASHMOOLA Vaat vikaras GOKSHURADI GUGGULU Shodhana with Triphala Niramavastha of Amavata & disorders of Mootravaha Srotas

114. Guggulu is without doubt number one choice of all practitioners as shaman aushadhi for vaat vikaras in Sandhi , asthi & majjagat vaat vikara . Preparation of Different Guggulu’s is very easy and hassle free. Guggulu preparations are relatively cheaper. Guggulu acts as rasayana and special preparations like Maha yograja guggulu , P anchtikt loha guggulu Different ingredients of guggulu preparations gives us the clue where to use what e.g Sravi V rana = K aishore G uggulu, Trifla Guggulu Dry Skin disorders = P anchtikta Ghrita Guggulu 113 DISCUSSION

115. THANK YOU