HELLP Syndrome Powerpoint from the perspective of obgyn

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1. HELLP -Call for help?
Dr. Aarathi Bellary
Lead consultant Physician
KIMS Hospitals, Kondapur

2. agenda
INTRODUCTION
PATHOGENESIS
MANAGEMENT
STRATEGIES
NOVEL THERAPIES
CLINICAL TAKEAWAYS

3. •
HELLP syndrome is considered to be a
severe form of pre-eclampsia
Haemolysis(H), also expressed as
microangiopathic haemolyticanaemia,
elevated liver enzymes (EL), and low
platelets (LP)
The condition usually occurs antepartum,
between 27 and 37 weeks' gestation
15% to 30% of cases present initially
postpartum.
The disease is associated with progressive
and sometimes rapid maternal and fetal
deterioration.

4. The diagnosis of HELLP syndrome should be
considered in any pregnant patient presenting in
the second half of gestation or immediately
postpartum with significant new-onset
epigastric/RUQ pain until proven otherwise.
To meet diagnostic criteria
Liver transaminases [AST/ALT] should be elevated >70
IU/L, or twice the upper limit of normal concentration not
accounted for by alternative diagnoses.
Platelet count should be <100 x 10⁹/L
Haemolysismay be indicated by elevated total bilirubin (>1.2
mg/dl
LDH and AST elevations, and characteristic findings
(schistocytes) on a peripheral blood smear, haematuria,
worsening anaemia, and a low serum haptoglobin.

5. Pathogenesis

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12. Novel therapy
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Eculizumab,
a targeted inhibitor of complement protein C5, which
resulted in marked clinical improvement and complete
normalization of lab parameters.
Pregnancy was prolonged 17 days, likely resulting in a
reduction of neonatal morbidity with its associated short
and long-term health care costs. Successful use of
Eculizumab in this case suggests that complement
inhibition may be an effective treatment strategy for
severe preeclampsia/HELLP syndrome.

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14. Take aways
HIGH INDEX OF SUSPICION
DELIVERY IS THE DEFINITIVE
TREATMENT
PROMPT CARE

15. thank you
DR. AARATHIBELLARY
502-555-0152
[email protected]
draarathi.com