Heme catabolism

AMINO ACID METABOLISM

1. STUDY MATERIAL ON AMINO ACID METABOLISM Presented By: Ms. Sayali Dilip Powar (M. Pharm ) Department of Pharmaceutical Chemistry, @ Tatyasaheb Kore College of Pharmacy, Warananagar 1

2. General reactions of amino acid metabolism: Transamination, deamination & decarboxylation , urea cycle and its disorders Catabolism of phenylalanine and tyrosine and their metabolic disorders ( Phenyketonuria , Albinism, alkeptonuria , tyrosinemia ) Synthesis and significance of biological substances; 5-HT, melatonin, dopamine, noradrenaline , adrenaline Catabolism of heme ; hyperbilirubinemia and jaundice Amino acid metabolism 7/7/2021 2

3. Catabolism of Heme METABOLISM CATABOLISM ANABOLISM 7/7/2021 3

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5. INTRODUCTION TO CATABOLISM OF HEME 7/7/2021 11

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7. HEME FUNCTIONS 7/7/2021 13

8. Catabolism of heme Hemoglobin  Heme Heme  Biliverdin by “ Heme oxygenase ” Biliverdin  Bilirubin by “ Biliverdin reductase ” Bilirubin  Bilirubin diglucuronide by “ Bilirubin glucuronyltransferase ” Bilirubin diglucuronide  Urobilinogen by “ Microbial enzymes ” Urobilinogen  Urobilin (To urine) Urobilinogen  Stercobilin (To feces)

9. BLOOD CELLS Hemoglobin H e m e INTESTINE AND KIDNEY Urobilinogen Urobilin Excreted in Urine Stercobilin Excreted in Feces Biliverdin Bilirubin LIVER Bilirubin diglucuronide Bilirubin

10. Catabolism of heme Bilirubin is a bile pigment, and is the excretory end product of heme degradation.

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