HTN management & recent dev._250524.pptx

Recent update on Hypertension

1. Hypertension management & recent developments

2. Hypertension overview

3. 3 Natural History of a 35 year old man Build and BP Study: 1935-1954, Metro Life 1991

4. 4 Cardiovascular Disease in South Asia & India Among all CVD risks, high systolic blood pressure accounted for the largest proportion of DALYs at 46% Global Burden of Cardiovascular Diseases and Risks Collaboration, 1990-2021 (jacc.org)

5. Global Ranking of Risk Factors Contributing to All-Cause Mortality in 2019 Cardiovascular Disease DALYs attributable to Risk factors Hypertension is the leading causative factor for CVD and all-cause mortality

6. 6 Hypertension India 2023 country profile (who.int ) _assessed on 21 st feb,2024 Indian report on Hypertension “The Silent Killer” 1/3 rd are suffering from Hypertension

7. Hypertension: Awareness, Treatment & Control Curr Opin Cardiol 2019, 34:331–341 7

8. Schematic model of untreated hypertension Hala Yamout and George L. Bakris. Use of Combination Therapies. HYPERTENSION A Companion to Braunwald’s Heart Disease. Third Edition . 2018

9. 9 Aram V. Chobanian . Med Clin N Am 101 (2017) 219–227. Hypertension BP Level and Classification

10. Hypertension . 2020;75:1334-1357 10 Office Blood Pressure Measurement Home and Ambulatory BP Measurement

11. Hypertension control

12. 12 Hypertension control key to reducing CVD deaths The percentage by which deaths from cardiovascular diseases (CVDs) could be reduced if specific risk factors were brought under control

13. EVOLUTION OF BP TARGETS- A moving goal post It is challenging to determine an ideal range of blood pressure by simple measurement that has long-term positive outcome. Pathophysiological alterations, comorbidities, different postures, and different circumstances contribute to blood pressure variation

14. Office BP targets for drug treatment

15. 15 Early BP screening and the importance of education at younger ages as a part of primary & primordial prevention

16. 16 Main class of antihypertensive drugs Blood Pressure 2024, VOL. 33, NO. 1, 2320401, https://doi.org/10.1080/08037051.2024.2320401

17. 17 General treatment algorithm for patients with high blood pressure Annals of Medicine 2024, VOL. 56, NO. 1, 2338242, https://doi.org/10.1080/07853890.2024.2338242

18. Hypertension control: Newer Drugs

19. 19 New antihypertensive drugs in development Blood Pressure 2024, VOL. 33, NO. 1, 2320401, https://doi.org/10.1080/08037051.2024.2320401

20. 20 New antihypertensive drugs in development Blood Pressure 2024, VOL. 33, NO. 1, 2320401, https://doi.org/10.1080/08037051.2024.2320401

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22. ARNI in Hypertension Approved by Regulatory Authority of Japan ( Pharmaceuticals and Medical Devices Agency ) in 2021 Approved by Regulatory Authority of China ( National Medical Products Administration ) in 2021 ESC Hypertension guidelines 2023 recommended ARNI for hypertension with heart failure

23. Clinical Research in Cardiology (2023) 112:855–867

24. Radar plot of various doses for all outcomes Results of the SUCRA analysis. 200 mg once daily of sacubitril /valsartan located in the outer area of radar plot for msSBP , 24-h maSBP , and 24-h maDBP , indicating that it might be the best treatment option for lowering msSBP , 24-h maSBP , and 24-h maDBP Clinical Research in Cardiology (2023) 112:855–867

25. Resistant Hypertension and role of RDN

26. 36 The most common characteristics observed in RH patients Int. J. Mol. Sci. 2023, 24, 12911

27. BP-lowering strategy in true resistant hypertension 2023 ESH Guidelines for the management of arterial hypertension

28. 2023 ESH Guidelines for the management of arterial hypertension

29. Absolute systolic blood pressure (BP) reduction in renal denervation studies reporting on both short-term (2–6 months) and longer term (36 months) outcomes (Hypertension. 2024;81:1194–1205. DOI: 10.1161/HYPERTENSIONAHA.123.21715 .)

30. Device Therapy for Drug-Resistant Hypertension List of current renal denervation devices, their specifications and latest clinical trials Irish Journal of Medical Science (1971 -), https://doi.org/10.1007/s11845-020-02421-1

31. THANK YOU Regular Check-up is Necessary