Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)

Hyocimax Plus (Generic Hyoscine Butylbromide and Acetaminophen Tablets) are used for the relief of spasm of the genito-urinary tract or gastro- intestinal tract and for the symptomatic relief of Irritable Bowel Syndrome.
This medicine is also used to treat functional disorders in the biliary and urinary tracts and female genital organs (e.g. dysmenorrhoea) including menstrual cramps and urinary tract spasm.

1. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy

2. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Hyocimax Plus (Generic Hyoscine Butylbromide and Acetaminophen
Tablets) are used for the relief of spasm of the genito-urinary tract
or gastro- intestinal tract and for the symptomatic relief of Irritable
Bowel Syndrome.
This medicine is also used to treat functional disorders in the
biliary and urinary tracts and female genital organs (e.g.
dysmenorrhoea) including menstrual cramps and urinary tract
spasm.

3. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Hyocimax Plus Tablets are manufactured
by Acme Pharmaceuticals Limited,
India and marketed by German
Remedies (Cadila Healthcare).
They are available in the strength of 510
mg i.e. Hyoscine Butylbromide 10 mg &
Acetaminophen (Paracetamol) 500 mg

4. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy

Chemical Structure - Hyoscine Butylbromide

5. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy

Chemical Structure - Acetaminophen (Paracetamol)

6. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
The active ingredients contained in
Hyocimax Plus tablets are Hyoscine
Butylbromide and Acetaminophen
(Paracetamol).
Each Hyocimax Plus tablet contains 10
mg of Hyoscine Butylbromide and 500
mg of Acetaminophen (Paracetamol).

7. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Uses of Hyocimax 10mg Tablets:
Hyocimax Plus (Generic Hyoscine Butylbromide tablets) is a
treatment in adult patients and children 6 to 12 years for the relief of
smooth muscle spasm/cramping of the gastrointestinal system and its
associated pain and discomfort.
Hyocimax Plus tablets contains two medicines, Hyoscine
Butylbromide which belongs to a group of medicines called
“antispasmodics” and Acetaminophen (Paracetamol).
Hyocimax Plus tablets are used to relieve cramps in the muscles of
the Stomach, Gut (intestine) Bladder, female genital organs (e.g.
dysmenorrhoea), menstrual cramps and the tubes that lead to the
outside of your body (urinary system).
It can also be used to relieve the abdominal cramps which cause
pain and discomfort associated with Irritable Bowel Syndrome (IBS).

8. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Recommended Dosage
The dose of
Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets) for
adult patients is 1 to 2 tablets 3 times daily. The total daily dose
should not exceed 6 tablets .
Hyocimax Plus tablets should not be chewed, but swallowed in
whole with a sufficient amount of water.

9. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Contraindications
➔Hyocimax Plus tablets are contraindicated in patients with a known
hypersensitivity to Hyoscine Butylbromide, Acetaminophen
(Paracetamol) or any other component of the tablet.
➔Patients with myasthenia gravis.
➔Mechanical stenosis in the gastrointestinal tract
➔Paralytical or obstructive ileus
➔Megacolon
➔Narrow angle glaucoma
➔Severe hepatocellular insufficiency (Child - Pugh C).

10. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Storage Instructions
Hyocimax Plus (Generic Hyoscine Butylbromide and
Acetaminophen Tablets) have to be stored at
controlled room temperature i.e. from 20°C to 25°C
(68°F to 77°F) with excursions permitted between
15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away from
children and pets.

11. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Warnings
In case severe, unexplained abdominal pain persists or worsens, or occurs
together with symptoms like fever, nausea, vomiting, changes in bowel
movements, abdominal tenderness, decreased blood pressure, fainting, or
blood in stool, medical advice should immediately be sought.
Hyocimax Plus 510 mg tablets should be used with caution in conditions
characterised by tachycardia such as thyrotoxicosis, cardiac insufficiency or
failure and in cardiac surgery where it may further accelerate the heart rate.
Due to the risk of anticholinergic complications, caution should be used in
patients susceptible to intestinal or urinary outlet obstructions.
Because of the possibility that anticholinergics may reduce sweating, Hyocimax
Plus should be administered with caution to patients with pyrexia.

12. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Warnings
Elevation of intraocular pressure may be produced by the
administration of anticholinergic agents such as Hyocimax Plus in
patients with undiagnosed and therefore untreated narrow angle
glaucoma. Therefore, patients should seek urgent ophthalmological
advice in case they should develop a painful, red eye with loss of vision
whilst or after taking Hyocimax Plus.
As the tablet coat contains sucrose (41.2 mg), patients with rare
hereditary problems of fructose intolerance, glucose-galactose
malabsorption or sucrase-isomaltase insufficiency should not take
Hyocimax Plus tablets.

13. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Warnings
Hyocimax Plus contains Acetaminophen (Paracetamol).
Severe liver damage may occur if an adult takes more than 4000 mg of
Acetaminophen in 24 hours (8 tablets of this medicine), which is the
maximum daily amount.
Do not use with any other medicine containing Acetaminophen
(prescription or nonprescription). If you are not sure whether a
medication contains Acetaminophen, ask a doctor or pharmacist
Severe liver damage may occur if adult has 3 or more alcoholic drinks
every day while using this product.

14. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Possible Side Effects
Hyoscine Butylbromide and Acetaminophen (Hyocimax Plus tablets)
side effects are given below:
Side effects due to Hyoscine Butylbromide
Immune system disorders: Frequency Not known: anaphylactic shock,
anaphylactic reactions, dyspnoea, other hypersensitivity
Cardiac disorders: Uncommon: tachycardia
Gastrointestinal disorders: Uncommon: dry mouth
Skin and subcutaneous tissue disorders: Uncommon: skin reactions (e.g.
urticaria, pruritus), abnormal sweating. Frequency Not known: rash,
erythema
Renal and urinary disorders: Rare: urinary retention

15. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Possible Side Effects
Hyoscine Butylbromide and Acetaminophen (Hyocimax Plus tablets)
side effects are given below:
Side effects due to Acetaminophen (Paracetamol):
The most common side effects in patients treated with Acetaminophen
(Paracetamol) were nausea, vomiting, headache, and insomnia in adult
patients and nausea, vomiting, constipation, pruritus, agitation, and
atelectasis in pediatric patients.

16. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Hyocimax Plus Overdosage
Hyocimax Plus tablets is made up of two medicines: Hyoscine
Butylbromide and Acetaminophen (Paracetamol).
Serious signs of poisoning following acute overdosage of Hyoscine
Butylbromide have not been observed in man.
In the case of overdosage, anticholinergic effects such as urinary
retention, dry mouth, reddening of the skin, tachycardia, inhibition of
gastrointestinal motility and transient visual disturbances may occur,
and Cheynes-Stokes respiration has been reported.

17. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Hyocimax Plus Overdosage
In acute Acetaminophen overdosage, dose-dependent, potentially
fatal hepatic necrosis is the most serious adverse effect. Renal
tubular necrosis, hypoglycemic coma, and thrombocytopenia may
also occur.
Early symptoms following a potentially hepatotoxic overdose may
include: nausea, vomiting, diaphoresis, and general malaise. Clinical
and laboratory evidence of hepatic toxicity may not be apparent until
48 to 72 hours post-ingestion.

18. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Treatment of Hyocimax Plus Overdosage
In the case of oral poisoning, gastric lavage with medicinal charcoal
should be followed by magnesium sulfate (15%). Symptoms of Hyoscine
Butylbromide overdosage respond to parasympathomimetics.
For patients with glaucoma, pilocarpine should be given locally.
Cardiovascular complications should be treated according to usual
therapeutic principles. In case of respiratory paralysis, intubation and
artificial respiration should be considered. Catheterisation may be
required for urinary retention.
In addition, appropriate supportive measures should be administered as
required.

19. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Treatment of Hyocimax Plus Overdosage
If an acetaminophen overdose is suspected, obtain a serum
acetaminophen assay as soon as possible, but no sooner than 4 hours
following oral ingestion. Obtain liver function studies initially and repeat
at 24-hour intervals. Administer the antidote N-acetylcysteine (NAC) as
early as possible. As a guide to treatment of acute ingestion, the
acetaminophen level can be plotted against time since oral ingestion on a
nomogram (Rumack-Matthew).
The lower toxic line on the nomogram is equivalent to 150 mcg/mL at 4
hours and 37.5 mcg/mL at 12 hours. If serum level is above the lower
line, administer the entire course of NAC treatment. Withhold NAC
therapy if the Acetaminophen level is below the lower line.

20. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Hyocimax Plus Tablets During Pregnancy
Hyocimax Plus tablets contain Hyoscine Butylbromide and Acetaminophen
(Paracetamol). Hyoscine Butylbromide and Acetaminophen (Paracetamol) have both
been classified by the US FDA as Pregnancy Category C.
There are limited data from the use of Hyoscine Butylbromide in pregnant women.
Animal studies are insufficient with respect to reproductive toxicity.
In limited reproductive toxicity studies Hyoscine Butylbromide showed no evidence of
teratogenicity in rats at 200 mg/kg in the diet or in rabbits at 200 mg/kg by oral gavage
or 50 mg/kg by subcutaneous injection.
Epidemiological data on oral Acetaminophen use in pregnant women show no increased
risk of major congenital malformations. It is not known whether Acetaminophen can
cause fetal harm when administered to a pregnant woman.
As a precautionary measure Hyocimax Plus tablets are not recommended during
pregnancy.

21. Hyocimax Plus (Generic Hyoscine and Acetaminophen Tablets)
© The Swiss Pharmacy
Hyocimax Plus Tablets are manufactured by Acme
Pharmaceuticals Limited, India and marketed by German
Remedies.
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