hypersensitivity reactions - brief overview

a brief description of hypersensitivity pathology of all four types from robbins and cotran

1. Hypersensitivity Reactions Learning Objectives: Define hypersensitivity reactions Classify the hypersensitivity reactions Discuss clinical examples of each type of hypersensitivity reactions Tabulate the comparison

2. Q: Antibody dependent cytotoxicity is associated with Type I hypersensitivity Type II hypersensitivity Type III hypersensitivity Type IV hypersensitivity Ans : B

3. Q: type IV hypersensitivity is also called as Immediate hypersensitivity Delayed hypersensitivity Cytotoxic hypersensitivity Immune complex hypersensitivity Ans : B

4. Q: type III hypersensitivity is triggered by Mast cells and Ig E K cells and Ig G Deposition of antigen and antibody complex Th cells Ans : C

5. Q: A 56 years old male had an attack of asthma during spring season. He has cough and shortness of breath. On examination he has bilateral wheeze. Which antibody is responsible for this allergic reaction? Ig G Ig M Ig A Ig E Ans : D

6. Q: A 35 years old female presents with history of 5 kg weight loss, insomnia and tachycardia. A physician diagnosed her as a case of Graves disease. He contacted his pathology friend to know the pathophysiology of the disease. Which type of hyper sensitivity reaction is the Graves disease? Anti body mediated Delayed type Free antigen – antibody immune complex Fixed antigen – antibody immune complex Ans : D

7. Q: A patient is poisoned by a snake and treated with serum immunoglobulin. This causes an antibody-mediated systemic inflammation and itchy rash two days later. What type of hypersensitivity reaction is this ? Type I Type II Type III Type IV Ans : c