hyperuricemia ppt.pptx presentation on hyperuricemia

Presentation on hyperuricemia contains introduction of hyperuricemia and the causes of hyperuricemia

1. Amity University, Raipur Amity Institute of Pharmacy Presentation on hyperuricemia Name – Muskan Chakradhari Enrollment no.- A81313324008 Subject – Biochemistry Submitted to – Aarti Gupta mam

2. Content Hyperuricemia Causes of hyperuricemia Pathophysiology of hyperuricemia Symptoms of hyperuricemia Risk factors Diagnosis Treatment

3. Hyperuricemia It is an excess of uric acid in the blood. Uric acid passes through the liver and enters to the blood stream. Purine breakdown into uric acid . Purine are nitrogen containing compounds which are made inside of our body. Increased level of uric acid may accumulate in tissue and form crystals. The amount of urate in the body depends upon the amount of purines eaten in food. About 70% of produced uric acid is excreted through the kidneys and 30% passed into the intestine.

4. Causes of hyperuricemia Uric acid underexcretion– Poor rate of uric acid excretion. Uric acid overproduction - Over production of uric acid caused by external factors like high purine diet , medication ,etc. Combined causes - Cause due to combination of uric acid underexcretion and uric acid overproduction, alcohol consumption, presence of disease.

5. Pathophysiology of hyperuricemia Uric acid is the result of purine breakdown. Purine metabolism mainly occurs in liver . Purine Metabolism: Purines, like adenine and guanine, are naturally broken down in the body, with inosine as a key intermediate.
Hypoxanthine Formation: Inosine is converted to hypoxanthine by the enzyme purine nucleoside phosphorylase.
Xanthine Formation: Hypoxanthine is then oxidized to xanthine by xanthine oxidase.
Uric Acid Formation: Xanthine is further oxidized to uric acid by xanthine oxidase.

6. Symptoms Kidney stones Swelling and redness in joints Fever Itching Vomiting Intense pain joints

7. Risk factors Dietary factors (Alcohol consumption , purine rich diet ) Risk increase with age Lifestyle factors (Dehydration , weight loss or fasting)

8. Diagnosis Physical examination Blood test Urine test X –Rays Treatment – Avoid alcohol consumption Exercise Pharmacological therapy (e.g. corticosteroids) Monitor renal function

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