IBUPROFEN ASSIGNMENT 1.pptx , power point presentation on medicine ibuprofen

This power point presentation is about the medical drug ibuprofen, states its function in a medical environment.

1. IBUPROFEN Sahil Ram ID 20200425

2. Introduction Ibuprofen is a traditional non-steroidal anti-inflammatory drug widely used in the treatment of mild to moderate pain and inflammation.  It was discovered by Stewart Adams in 1961. It was used for the treatment of rheumatoid arthritis and osteo arthritis. Formula = C 13 H 18 O 2.

3. Chemical Structure

4. Stereoisomerism in Ibuprofen Chiral Center: A chiral center is a carbon atom that is attached to four different groups. Enantiomers of Ibuprofen: (S)-ibuprofen (S-(+)-ibuprofen ). (R)-ibuprofen (R-(−)-ibuprofen ).

5. R &S Enantiomer

6. Uses: (Analgesic)Used for pain relief such as headaches, toothaches, back pain, muscle aches, and minor injuries . (Anti-Inflammatory) effective in treating conditions that involve inflammation, such as arthritis. ( Antipyretic ) fever reduction in both adults and children.

7. Mechanism of Action of Ibuprofen Inhibition of Cyclooxygenase (COX) Enzymes. Ibuprofen primarily exerts its effects by inhibiting the cyclooxygenase enzymes, COX-1 and COX-2 . Reduction of Prostaglandin Synthesis. Analgesic, Anti-inflammatory, and Antipyretic Effects.

8. Metabolism of Ibuprofen Absorption. Distribution. Hepatic Metabolism . Excretion.

9. Side Effects of Ibuprofen Gastrointestinal Effects: Nausea, Vomiting, and Diarrhea, Gastric Ulcers. Central Nervous System Effects: Headache and Dizziness. Renal Effects: Kidney Function. Cardiovascular Effects: Increased Blood Pressure

10. Future Developments in Ibuprofen Development of Safer NSAIDs: Selective COX-2 Inhibitors Improved Gastrointestinal Safety. Combination Therapies: NSAIDs with Gastroprotective Agents IBuprofen with Omega-3 Fatty Acids.

11. Alternative to Ibuprofen Aspirin. Naproxen. Paracetamol.

12. Conclusion

13. References Boots Company PLC , 1961. Anti-inflammatory agents and methods for their preparation . [Patent] US 3,385,886 . Greenwood, R., 1998. The Discovery of Ibuprofen. In: T.A. Jacob (ed.), Profiles in Drug Synthesis . Boston: Butterworth-Heinemann, pp. 117-137 . Jones, B. & Widdowson , D., 1991. Ibuprofen: Chemistry and Mode of Action . London: Elsevier . Shukla, V.K. & Srivastava, A.K., 2012. Chemistry and Process of Ibuprofen Manufacturing . Journal of Advanced Chemical Research , 4(1), pp. 45-54.

14. References Sheldon, R.A., 2007. Green Chemistry: Sustainable Chemistry with a European Perspective . Green Chemistry Letters and Reviews , 1(1), pp. 13-21.