IgG group1.pptx

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1. GROUP NO 1 . IMMUNOGLOBULIN G(Ig G) Objectives Introduction Sub-types/sub-classes Properties Functions/roles of Ig G Deficit

2. Introduction Immunoglobulin G (Ig G) Is the most common and abundant antibody. Blood plasma consists of 75-80% of Ig G antibodies It has longest life span of about 23 days, It can cross the placental barrier and provide passive immunity to a developing fetus. Ig G antibodies remember the pathogens that have previously entered the body and caused an infection

3. PROPERTIES It is the most versatile Ig and can carry all function of Ig molecules It is the major Ig in serum It is the only Ig that crosses placenta It is also found in extra-vascular space It fixes complement although not all sub classes do this well It binds to cells and is a good poisoning (substance that enhance phagocytosis)

4. SUB-CLASSES/TYPES Ig G Is the combination of four different types which are IgG1, IgG2, IgG3 and IgG4 IgG1 Is the most abundant IgG sub-class in human sera, it mediates antibody responses against viral pathogen IgG2 it protect against protein antigens but responsible for anti carbohydrate IgG responses against bacterial capsular polysaccharides. IgG3 it is known to promote inflammation as is associated with enhanced control or protection against a range of intracellular bacteria, parasite and viruses. IgG4 It is believed to constitute a veritable antigen ‘garbage disposal’ system which can attenuate inflammation.

5. FUNCTIONS/ ROLES It binds and neutralizes toxin It protect the body from infection It play an important role in antibody dependent cell mediated cytotoxicity Involved in regulation of allergic reaction

6. DEFICIT IgG deficiency is a health problem in which a body does not make enough immunoglobulin G and predispose person to get infection IgG DEFICIENCY may be caused by aging, malnutrition, chemotherapy medicines and long term corticosteroids

7. DEFICIT SYMPTOMS Ear infections Pneumonia Sore throat Bronchitis Gastrointestinal infection

8. GROUP MEMBERS Egon Moshi Asmaa Aboubakary Neema Augustine Lilian Emmanuel Salma Abdalah Sitta Malenya Michael Daudi Agape Piniel