Immunological Basis of Graft Rejection

Immunological Basis of Graft Rejection
Transplantation in immunology, refers to the act of transferring cells, tissues, or organs from one site to another.
A healthy organ, tissue, cells which is provided by a donor is termed as a GRAFT.
The immune system has evolved elaborate and effective mechanisms to protect the organism from attack by foreign agents, and these same mechanisms cause rejection of grafts from anyone who is not genetically identical to the recipient.

1. IMMUNOLOGICAL BASIS OF GRAFT REJECTION Harshita Sharma MSc. Biotechnology, 3 rd Semester 190014155003 BT304

2. Transplantation : Transplantation in immunology, refers to the act of transferring cells, tissues, or organs from one site to another. A healthy organ, tissue, cells which is provided by a donor is termed as a GRAFT. The immune system has evolved elaborate and effective mechanisms to protect the organism from attack by foreign agents, and these same mechanisms cause rejection of grafts from anyone who is not genetically identical to the recipient.

3. Type of Grafts : Autograft is self-tissue transferred from one body site to another in the same individual. Isograft is tissue transferred between genetically identical individuals. Allograft is tissue transferred between genetically different members of the same species. Xenograft is tissue transferred between different species. Autografts and isografts are usually accepted, owing to the genetic identity between graft and host.

4. Allograft rejection shows specificity and memory .

5. Rejection due to Memory, Specificity and T-cells :

6. Role of Major Histocompatibility Complex :

7. RBC and HLA Typing :

8. MICROCYTOTOXICITY TEST

9. MIXED LYMPHOCYTE REACTION :

10. Cell Mediated Graft Rejection : 1. SENSITIZATION STAGE

11. 2. EFFECTOR STAGE

12. THANK YOU