In A Nutshell: Endometrial Cancer Molecular Subtypes

In recent years, molecular subtypes have played an increasingly important role in classifying endometrial cancers and driving important clinical decisions. Join us on Facebook Live as Dr. Tashanna Myers, Division Chief, Gynecologic Oncology and Vice Chair Academic Affairs for the Department of OB/GYN at Baystate Medical Center, discusses the key molecular subtypes to provide you with a better understanding of the basics.

1. The Cancer Genome Atlas: Molecular Classification for Endometrial Cancer
MOLECULAR
SUBTYPE
POLE
Ultramutated
MSI-H Copy number low
P53 wild type
Copy number
highP53
mutation
PROGNOSIS best intermediate intermediate worse
Potential
Treatment
Options
No additional or
de-escalation
Immunotherapy,
PD-L1 inhibitors
Chemotherapy
Distribution of
Endometrioid
tumors
~4% ~39% ~48% ~9%
Histologic TypesEndometrioid
Grade 1-3
Endometrioid
Grade 1-3
Endometrioid
Grade 1-2
Grade 3,
Carcinosarcoma,
Serous
Diagnostic testNext generation
sequencing
IHC IHC IHC