Indomethacin drug presentation

Basics regarding indomethacin drug.
Indomethacin class,chemical or pharmacological name.
Indications and contraindications of indomethacin.
Side effects of indomethacin.
Pediatric dosage for indomethacin.
Nurses responsibility.

1. I N D O M E T H A CIN S h i v n e tri Chauhan B . s c ( N ) 3 r d y r . R a m a c o l l ege of n ursing . B Y :

2. I N T R O D U C T ION Indomethacin i s i n d o l e -3-a c e t i c a c i d d e r i v a t ive c l a s s i f i e d a s N S A I D s . P r i m a r ily i t i s a n a n t i - i n f l a m m a tory d r u g .

3. D R U G A N D IT'S G R O U P Non S t e r o i d a l a n t i - i n f l a m m atory d r u g s .

4. T R A D E N A M E I n d o c i n P H A R M A C O L O G I C A L N A M E 4 - c h l o r o b e n z o y l - 5 - m e t h o x y - 2 - m e t h y l - 1 - i n d o l e - 3 - a c e t i c a c i d

5. D O S A G E T h e d o s e o f i n d o m e t h a cin v a r i e s a s p e r diffe r ent b o d y p r o b l ems : F or R h e u m a t oid A r t h i r i t i s I n i t i a l d o s e i s 1 - 2 m g / k g / d a y o r a l ly i n d i v i d e d d o s e s . M a x i m u m d o s e i s 3 - 4 m g / k g / d a y .

6. F o r a n k y l o s i n g s p o n d y l i t i s I n i t i a l d o s e i s 2 5 m g o r a l l y 2 - 3 t i m e s a d a y . M a i n t e n ance d o s e i s a s p e r t h e p a t i e nts t o l e r a t i o n w i t h i n c r e m e n t o f 2 5 - 5 m g w e e k l y u n t i l s a t i s f a c tory r e s p o nse o r m a x i m u m d o s e i s a c h i e v e d . T h e m a x i m u m d o s e i s 1 m g i n s i n g l e d o s e a n d 2 m g i n d a i l y d o s e .

7. F o r o s t e o arthritis 2 5 m g o r a l l y 2 - 3 t i m e s p e r d a y . M a i n t e n a nce d o s e i s i n c r e m e nt o f 2 5 - 5 m g weekly u n t i l g e t s a t i s factory r e sponse . M a x i m um s i n g l e d o s e i s 1 m g . M a x i m u m d a i l y d o s e i s 2 m g

8. F o r B u r s i t i s a n d T e n d i n i tis 7 5 - 1 5 m g o r a l l y p e r day i n 3 - 4 d i v i d e d d o s e s .

9. F o r P a t e n t d u c t u s a r teriosus A g e a t f i r s t d o s e : L e s s t h a n 4 8 h r s : F i r s t d o s e : . 2 m g / k g I V Second d o s e : . 1 m g / k g I V T h i r d dose: . 1 m g / k g I V

10. A g e a t f i r s t d o s e : 2 - 7 d a y s : F i r s t d o s e : . 2 m g / k g I V S e c o n d d o s e : . 2 m g / k g I V T h i r d d o s e : . 2 m g / k g I V A g e a t f i r s t d o s e : O v e r 7 d a y s F i r s t d o s e : . 2 m g / k g I V Second dose : . 2 5 m g / k g I V T h i r d d o s e : . 2 5 m g / k g I V

11. S T R E N G T H I n d o m e t h a cin o r a l s u s p e nsion i s o f 2 5 m g p e r 5 m l i s a n o f f w h i t e s u s p e n s ion .

12. Route O f A d m i n i stration O R A L I V SUPPOSITORY

13. P H A R M A C O K I N E T I C S H a l f l i f e i s a b o u t 5 - 1 h r s . M e t a b o l i s e d i n l i v e r . Excreted via k i d n e y . U n d e r g o e s appreciable e n t e r o h e p a t i c c i r c u l a t i o n .

14. M e c h a n i s m O f A c t i o n I n d o m e t h a cin p r o d u c e s p o t e n t a n a l g e s ic a n d a n t i i n f l ammatory e f f e c t s b y i n h i b i t ing t h e synthesis o f p r o s t a glandi n s via i n h i b i ting t h e c y c l o o x y g e nase e n z y m e o r C O X e n z y m e .

15. INDICATIONS P a i n R h e u m a toid Arthritis P D A O s t e o arthritis S p o n d y l itis G o u t y a rthritis

16. CONTRAINDICATIONS H y p e r s e n sitivity Peptic u l c e r s A s t h m a U r t i c a r i a S u p p o s i t o ries a r e contraindicated i n p a t i e n t s w i t h h i s t o ry o f p r o c t i t i s o r r e c t a l b l e e d i n g .

17. S I D E EFFECTS Headache D i z z i n e s s D y s p e p s ia Hyponatremia N a u s e a H e a r t b u r n I n d i g e s t ion V o m i t i n g

18. N U R S E ' S R E S P O N S I B ILI T I E S Q u e s t i on p a t i e n t c a r e f ully r e g a r d i a s p i r i n s e n s i t i vity b e f o r e i n i t i a t i o n o f therapy . O b s e r v e p a t i e n t s c a r e f u l l y , i n s t r u c t t o r e p o r t a d v e r s e r e a c tions p r o m p t l y t o p r e v e n t s e r i o u s a n d s o m e t i m e s i r r e v e r s i b l e o r f a t a l e f f e c t s .

19. G i v e d r u g w i t h f o o d o r a f t e r m e a l s . D i s c o n t i n u e d r u g i f e y e changes o r s y m p t oms o f h e p a t i c o r r e n a l i m p a irment o c c u r . T e s t R F T b e t w e e n d o s e s . U s e t h e d r u g o n l y a s s u g g e s ted a n d a v o i d o v e r d o s e .

20. T H A N K U . . .