Inflammatory_and_Proliferative_Phases.pptx

wound healing is a process by which healing takes when the skin is broken

1. The Inflammatory Phase Duration: 0 to 3 Days post-injury Primary Goal: - Defend the wound against pathogens - Clean (debride) dead tissue & debris Key Outcome: Prepares the wound for the healing process

2. Signs and Early Response Clinical Signs: - Redness - Heat - Swelling - Pain First Responders – Neutrophils: - Phagocytosis of bacteria & debris - Release enzymes to break down damaged tissue

3. Transition to Repair Macrophages: - Continue phagocytosis - Secrete cytokines & growth factors to trigger repair Lymphocytes: - Arrive later - Regulate and control the immune response - Prepare transition to the Proliferative Phase

4. The Proliferative Phase Duration: Day 3 – up to 3 weeks Primary Goal: - Fill and cover the wound - Form connective tissue & new blood vessels - Restore the epithelial surface

5. Key Processes 1. Angiogenesis – New blood vessels (Endothelial cells) 2. Fibroplasia – Fibroblasts build collagen & ECM 3. Wound Contraction – Myofibroblasts shrink wound edges 4. Re-epithelialization – Keratinocytes cover wound surface

6. Granulation Tissue Appearance: Beefy red, moist, bumpy Composition: Capillaries, fibroblasts, collagen, ECM Significance: Healthy tissue indicates proper healing

7. Key Cells in Proliferative Phase - Fibroblasts: Deposit collagen & ECM - Endothelial cells: Form new vessels - Myofibroblasts: Contract wound edges - Keratinocytes: Cover wound with new epithelium