integration-modified n cellular 98.pptx

cellular neurobiology

1. Delta Rhythm of Sleep

2. Hippocampal oscillatory activity

3. Electrical Resonance

4. Thus, h-channels improve temporal precision of EPSP–spike coupling by reducing the temporal window during which an AP might be elicited.

5. Neural integration Spatial integration -ripples can combine

6. Phenomenology of dendritic spikes

7. The effect of ion channel distribution in Phenomenology of dendritic spikes

8. Effects of morphology on active integration

9. Effects of locations of input synapses on active integration

10. The regulatory effect of Ih on membrane excitability has been attributed to its partial activity at resting membrane potentials, resulting in a shunt conductance, which decreases the temporal integration of EPSPs . In addition , HCN channels have been shown to provide a tonic depolarizing current that increases resting activation of the delayed-rectifier M-type K+ channels along with inactivation of N- and T-type voltage-gated Ca2+ channe ls

11. 322

12. Effects of on path and off path on active integration

13. Rall ’ s early motivation (1959) Understand experimental synaptic potentials recorded at the soma Most of the input current flows into the dendrites (not directly to soma) Dendrites are non- isopotential electrical devices ( i ) voltage attenuates from synapse to soma; (ii) it takes time (delay) for the PSP to reach the soma; (iii) somatic EPS P/IPSP shape is expected to change with synaptic location

14. Axial current (originated from the synapse) Membrane current (lost via membrane resistance) synapse The origin of the passive (linear) cable equation Synaptic potentials attenuate from the synapse origin towards other regions of the dendrites

15. Neural integration

16. Sub linear summation

17. Sub linear summation

18. Neural integration Temporal integration -ripples can combine to make bigger ripples