Intra peritoneal (ip) route of drug administration

This route is preferred in rodents, but its applications in humans are also discussed here for better understanding. This presentation covers all the areas for IP Route with maximum details of route along with other basic details such as methods of drug aspiration etc.

1. Intra Peritoneal Route of Drug Administration Presented by: Zainab Bibi (L1F20PHMD0180) Muqaddas Raza (L1F20PHMD0060) Marwa Zaheer Ahmad (L1F20PHMD0052) Muhammad Umer (L1F20PHMD0176) Muhammad Nouman Azam (L1F20PHMD0054) Sheikh Talha Ali (L1F20PHMD0068) Muhammad Rohan Shahjahan (L1F20PHMD084)

2. Objectives In this presentation, you will be presented: Intra Peritoneal Route of Drug Administration Vectors for administration Containers for Storage of Medications Methods of Aspirations of drugs Procedure of IP Administration Distribution of Drug Applications of IP Route Pros and Cons Brands available in market

3. Intra Peritoneal(IP)Route Intra Peritoneal drug administration is a method of drug delivery via injection or infusion of a substance into the peritoneum, where it is absorbed by the lining. First Pass: The substance is subject to first pass through the liver. Fr equently Used Route: This route is frequently used in rodents for administration.

4. Vectors for administration Injections: Needle Size: 27 Gauge Angle: 30 Degree Site: Lower quadrant of abdomen Infusions (Catheters ): Material: Flexible Silicon tube Needle Size : 18 Gauge Angle: 45 Degrees Site: 4-5cm below belly button

5. Containers for Storage of Medication Ampoule Vial Disposable Bag

6. Procedure of IP Administration Use the gloves Wear face mask Wear neat clean aprin Take disposable syringe with 26 gauze needle Draw the solution to be administered in the syringe

7. Procedure of IP Administration Hold the animal neck between thumb and index finger Wrap remaining fingers on body and straighten them to restrain animal P lace to inject is lower right abdominal quadrant Insert the needle at angle of 30-42 degree into IP region Aspirate, and the gently push the piston and deliver the drug

8. Taped Representation

9. Distribution

10. Applications Peritoneal Dialysis: Peritoneal dialysis is a treatment for kidney failure that uses the lining of your abdomen to filter your blood inside your body . During peritoneal dialysis a cleansing fluid flows through a tube (Catheter) into part of your abdomen. The lining of abdomen act as a filter and remove waste product from your blood. After a set period of time , the fluid with filter waste products flows out of your abdomen and is discarded.

11. Applications Peritoneal Chemotherapy: The catheter is inserted to your peritoneal space . For IP the chemotherapy your medication will be mixed with fluid such as normal saline . It will be injected directly into your peritoneal space through your access port. The medication will directly target the cancer in your peritoneal space. This treatment method uses the higher dose of chemotherapy medication. About an hour later, the fluid is removed through the same port and the patient can go home.

12. Pros & Cons Significance: Convenient and easy to master. Less stressful/harmful. Suitable for variety of formulations. Large volumes can be administered. Large absorptive surface thus rapid absorption. Risks & Complications : High first pass metabolism. Abdominal organs may get punctured. Not suitable for irritating compounds. Can’t use hypertonic solutions. Risk of infection. Less clinical applicability.

13. Brands

14. References https://www.tititudorancea.com/z/intraperitoneal_route_of_administration.htm https:// www.perkinelmer.com/uk/lab-products-and-services/application-support-knowledgebase/in-vivo-preclinical-imaging/ip-injections-nirf.html https://www.pdempowers.com/patient/how-pd-works https://chemocare.com/chemotherapy/what-is-chemotherapy/how-chemotherapy-is-given.aspx https://www.researchgate.net/publication/41434592_Intraperitoneal_Drug_Therapy_An_Advantage Video Link: https://youtu.be/Lst96Kxd6vU

15. Question Answer Session !!!

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