Lacrisert.pptx

Name = Pavan Kumar
Topic = Lacrisert
M.Pharmacy (Pharmaceutics)
RR College of Pharmacy, Chhikabanavara, 560090
Bangalore

1. © R R INSTITUTIONS , BANGALORE RR COLLEGE OF PHARMACY DRUG DELIVERY SYSTEM Lacrisert SUBMITTED BY : SUBMITTED TO: PAVAN KUMAR Dr . A. GEETHA LAKSHMI 1 ST SEM , M.PHARMACY PROF. & HOD DEPARTMENT OF PHARMACEUTICS

2. CONTENTS © R R INSTITUTIONS , BANGALORE INTRODUCTION CONTENT OF LACRISERT PHYSICAL & CHEMICAL CHARACTERISTICS MECHANISM OF ACTION HOW TO USE LACRISERT USE DISADVANTAGE SIDE EFFECT REFERRENCE

3. INRODUCTION Lacrisert (hydroxypropyl cellulose) is a long-acting artificial tears insert that helps relieve eye dryness and irritation. It's placed between eyeball and lower eyelid. The insert can be difficult to place, especially in the beginning, but it only has to be placed once a day unlike similar eye drops. © R R INSTITUTIONS , BANGALORE

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5. IT CONSIST OF : Hydroxypropyl cellulose It is a derivative of cellulose that is soluble in both water and organic solvents. It is particularly good at trapping water and producing a film that serves as a barrier to water loss. Hydroxypropyl cellulose possesses good surface activity but does not gel as it forms open helical coils. In general Hydroxypropyl cellulose is a water-soluble thickener, emulsifier and film-former often used in tablet coating. © R R INSTITUTIONS , BANGALORE

6. PHYSICAL AND CHEMICAL CHARECTERSTICS The chemical name for hydroxypropyl cellulose is cellulose, 2-hydroxypropyl ether. It is a tasteless, odorless, and physiologically inert substance, and is soluble in water below 38°C. The ophthalmic inserts are sterile and translucent rods measuring 1.27 mm in diameter and 3.5 mm long. Each insert contains 5 mg of hydroxypropyl cellulose, with no preservatives or any other ingredients. © R R INSTITUTIONS , BANGALORE

7. MECHANISM OF ACTION Hydroxypropyl cellulose acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. Hydroxypropyl cellulose also acts to lubricate and protect the eye. © R R INSTITUTIONS , BANGALORE

8. How to use Lacrisert ? First, rinse the soft and flexible applicator with hot water. Shake off the excess. Then pick up the LACRISERT® insert by lightly touching it with the grooved tip of the applicator. © R R INSTITUTIONS , BANGALORE

9. VIDEO © R R INSTITUTIONS , BANGALORE

10. USES: In the treatment of Dry eye syndrome is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, burning, itching, foreign body sensation, dryness, pain. photophobia, hyperemia, visual disturbance, and tear film instability, with potential damage to the ocular surface. © R R INSTITUTIONS , BANGALORE

11. DISADVANTAGES Minimum rate of patient acceptance Need of expert during every insert SIDE EFFECTS: Temporary blurring of vision Discomfort Irritation or redness in the eye Sticky eyelashes Eye sensitivity to light Swelling of eyelid © R R INSTITUTIONS , BANGALORE

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13. REFRENCES Vyas SP, Khar KR. Targeted and controlled drug delivery system. 1st ed. Delhi: CBS publishers and distributors ; 2002 . Remington G. The science and practice of pharmacy.1st ed. Pennsylvania: Mack publication Company : 1563-1567. Tangri P, khurana S. Basis of ocular drug delivery system . Int J Pharm Biomed Res [Internet]. 2011 Oct [ cited 2014 Jul 05]; 2(4):1540-1541.Available from:http :// www.ijrpbsonline.com/files/RV15.pdf Patel V, Agarwal YK, Current status and advanced approaches in ocular drug delivery system. J Global Trends Pharm. Sci [internet]. 2011 Apr [cited 2014 July 14]; 2(2):131-48. Available from : http ://www.jgtps.com/Patel.pdf www.google.com © R R INSTITUTIONS , BANGALORE

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