1
Explain the transport mechanisms in cells (bluk
or vesicular transport) (STEM_BIO11/12-Ig-h-14).
2
How do large molecules such as
proteins pass through the cell?
3
Proteins help our body for muscle development, improved
immune system, bone development, and metabolism.
Proteins are one of the essential macromolecules needed
for different cellular processes.
4
Vesicles
●These are structures
within or outside a cell,
consisting of a cytoplasm
and enclosed by a lipid
bilayer.
Structure of a vesicle
Bulk or Vesicular Transport
5
Vesicles
●These are formed
naturally during the
process of secretion,
uptake, and transport of
molecules.
Structure of a vesicle
Bulk or Vesicular Transport
6
Golgi Bodies
●The Golgi body often
produces the vesicles
that carry these cell
products to the
membrane.
Golgi bodies producing
transport vesicles
Bulk or Vesicular Transport
7
Bulk or vesicular transport
general mechanism
Budding
Scissio
n
Uncoati
ng
Transl
ocation
Tetheri
ng
Fusion
General Mechanism of Bulk Transport
8A selected cargo undergoing the general steps of bulk transport
General Mechanism of Bulk Transport
Coat proteins bind
to sorting signals
9A selected cargo undergoing the general steps of bulk transport
General Mechanism of Bulk Transport
A soluble cargo is
selected
10A selected cargo undergoing the general steps of bulk transport
General Mechanism of Bulk Transport
The membrane
deforms and it
forms a “bud”
containing the
molecule.
11A selected cargo undergoing the general steps of bulk transport
General Mechanism of Bulk Transport
Scission proteins
help release the
coated vesicle
containing the
selected material.
12A selected cargo undergoing the general steps of bulk transport
General Mechanism of Bulk Transport
The coat
proteins are
removed
through the
process of
uncoating.
13A selected cargo undergoing the general steps of bulk transport
General Mechanism of Bulk Transport
Determine
whether it is a
correct target.
14A selected cargo undergoing the general steps of bulk transport
General Mechanism of Bulk Transport
The vesicle will
move closer to
the target
membrane for
fusion.
15A selected cargo undergoing the general steps of bulk transport
General Mechanism of Bulk Transport
The vesicle
delivers its
membrane
components
then it
physically fuses
with the target
membrane.
17
How are the types of vesicular transport
different from one another?
18
General Mechanism of Bulk Transport
Types of
Vesicular
Transport
Phagocytosis
Exocytosis
Pinocytosis
Receptor-mediated
endocytosis
19
Types of Vesicular Transport
Types of
Vesicular
Transport
Phagocytosi
s
Exocytosis
Pinocytosis
Receptor-
mediated
endocytosis
20
Types of Vesicular Transport
Types of
Vesicular
Transport
Phagocytosi
s
Exocytosis
Pinocytosis
Receptor-
mediated
endocytosis
21
Types of Vesicular Transport
Types of
Vesicular
Transport
Phagocytosi
s
Exocytosis
Pinocytosis
Receptor-
mediated
endocytosis
22
Types of Vesicular Transport
Types of
Vesicular
Transport
Phagocytosi
s
Exocytosis
Pinocytosis
Receptor-
mediated
endocytosis
23
Which among the types of bulk transport is
shown by the process wherein the white
blood cells release antibodies as an
immune response?
24
Identify the terms being described by the following
statements.
1.Inthisprocess,theplasmamembraneballoonsinward
takinginthemolecule.
2.Inthisprocessofendocytosis,thecellengulfsthe
moleculethroughtheuseofitsextensionsthenitpacks
themoleculesinavacuole.
3.Thiskindofendocytosisformsavesiclearoundaliquid
molecule.
25
●Larger molecules that cannot be carried through
transport proteins can be transported into and out of
the cell through bulk or vesicular transport.
●Molecules that can be transported through the
process of bulk transport include proteins,
polysaccharides, andnucleic acids.
26
●There are different processes involved in bulk
transport which are budding, scission, uncoating,
translocation, tethering andfusion.
●Exocytosisis a process of transporting molecules
outside the cell while endocytosisis transporting the
molecules into the cell.
27
●The two kinds of endocytosis are phagocytosis and
pinocytosis.
○Phagocytosisis a process of endocytosis in
which the cell engulfs the molecules.
○In pinocytosis, the vesicles form around a liquid.
28
●A special form of pinocytosis is known as receptor-
mediated endocytosiswhich enables the cell to
acquire solutes through the coated pit that pinches to
form a vesicle.
29
General mechanism of bulk or vesicular transport
3030
Neurotransmitters are stored inside small
sacs called synaptic vesicles which are
released into the synaptic cleft of the
synapse. These are used to communicate
with each other at junctions known as
chemical synapses. What type of bulk
transport is being used in the situation?
Justify your answer.
31
●Slide 10: Golgi apparatus_ borderless version)-
en.svgby Kelvinsong, is licensed under CC BY 3.0
via Wikimedia Commons.
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