Lifecycle of malarial parasite

The life cycle of malarial parasite power point presentation.

1. LIFECYCLE OF LIFECYCLE OF
MALARIAL PARASITEMALARIAL PARASITE
Soorej Jaiboi KSoorej Jaiboi K

2. MALARIAMALARIA
MalariaMalaria is a mosquito borne infectious is a mosquito borne infectious
disease affecting humans and other disease affecting humans and other
animals caused by parasitic protozoans (a animals caused by parasitic protozoans (a
group of single-celled microorganisms) group of single-celled microorganisms)
belonging to the belonging to the Plasmodium typePlasmodium type..

4. LIFECYCLE LIFECYCLE
In the life cycle of In the life cycle of PlasmodiumPlasmodium, a female , a female
AnophelesAnopheles mosquito (the definitive host) mosquito (the definitive host)
transmits a motile infective form (called transmits a motile infective form (called
the sporozoite) to a vertebrate host such the sporozoite) to a vertebrate host such
as a human (the secondary host), thus as a human (the secondary host), thus
acting as a transmission vector. acting as a transmission vector.

6. The malaria parasite life cycle involves two The malaria parasite life cycle involves two
hosts.hosts.
During a blood meal, a malaria-infected female During a blood meal, a malaria-infected female
AnophelesAnopheles mosquito inoculates sporozoites mosquito inoculates sporozoites
into the human host .into the human host .
1)Sporozoites infect liver cells.1)Sporozoites infect liver cells.
2)Mature into schizonts. 2)Mature into schizonts.

8. 3) Which rupture and release merozoites. 3) Which rupture and release merozoites.
4) After this initial replication in the liver ,the 4) After this initial replication in the liver ,the
parasites undergo asexual multiplication in parasites undergo asexual multiplication in
the erythrocytes .Merozoites infect red blood the erythrocytes .Merozoites infect red blood
cells.cells.
5) The ring stage trophozoites mature into 5) The ring stage trophozoites mature into
schizonts, which rupture releasing schizonts, which rupture releasing
merozoites. merozoites.

10. 6) Some parasites differentiate into sexual 6) Some parasites differentiate into sexual
erythrocytic stages (gametocytes). erythrocytic stages (gametocytes).
7) Blood stage parasites are responsible for the 7) Blood stage parasites are responsible for the
clinical manifestations of the disease. clinical manifestations of the disease.
8) The gametocytes, male (microgametocytes) 8) The gametocytes, male (microgametocytes)
and female (macrogametocytes), are ingested and female (macrogametocytes), are ingested
by an by an AnophelesAnopheles mosquito during a blood mosquito during a blood
meal. meal.

12. C) The parasites multiplication in the mosquito C) The parasites multiplication in the mosquito
is known as the sporogonic cycle.is known as the sporogonic cycle.
9) While in the mosquito's stomach, the 9) While in the mosquito's stomach, the
microgametes penetrate the macrogametes microgametes penetrate the macrogametes
generating zygotes. generating zygotes.
10) The zygotes in turn become motile and 10) The zygotes in turn become motile and
elongated (ookinetes). elongated (ookinetes).

14. 11) Which invade the midgut wall of the 11) Which invade the midgut wall of the
mosquito where they develop into oocysts. mosquito where they develop into oocysts.
12) The oocysts grow, rupture, and release 12) The oocysts grow, rupture, and release
sporozoites. sporozoites.
13) Which make their way to the mosquito's 13) Which make their way to the mosquito's
salivary glands. Inoculation of the sporozoites salivary glands. Inoculation of the sporozoites
into a new human host perpetuates the malaria into a new human host perpetuates the malaria
life cycle. life cycle.

15. Only female mosquitoes feed on blood,male Only female mosquitoes feed on blood,male
mosquitoes feed on plant nectar, and do not mosquitoes feed on plant nectar, and do not
transmit the disease.transmit the disease.
Malaria parasites can also be transmitted by Malaria parasites can also be transmitted by
blood transfusions, although this is rare.blood transfusions, although this is rare.