Liposomes-Tiny-Vesicles-with-Big-Potential.pptx

Liposome research

1. Liposomes: Tiny Vesicles with Big Potential Liposomes are tiny, spherical vesicles with a lipid bilayer membrane. They are used in various applications, including drug delivery, gene therapy, and cosmetics. AC by Argha Chakraborty

2. Liposome Structure and Composition Lipid Bilayer Liposomes are primarily composed of phospholipids, especially phosphatidylcholine and cholesterol. Aqueous Core The core of a liposome is filled with an aqueous solution, which can encapsulate hydrophilic molecules.

3. Liposome Types Multilamellar Vesicles (MLV) MLVs have multiple lipid bilayers, forming concentric circles. Unilamellar Vesicles (SUV, MUV, LUV, GUV) Unilamellar vesicles have a single lipid bilayer, varying in size. Multivesicular Vesicles (MVV) MVVs contain one or more smaller vesicles within a larger vesicle.

4. Liposome Applications: Drug Delivery 1 Encapsulation Liposomes can encapsulate both hydrophilic and hydrophobic molecules. 2 Targeted Delivery Liposomes can be designed to target specific cells or tissues. 3 Improved Drug Efficacy Liposomes can protect drugs from degradation and enhance their delivery.

5. Liposome Applications: Gene Therapy 1 Gene Delivery Liposomes can deliver genetic material, such as DNA or RNA, into cells. 2 Transfection The process of delivering genetic material using liposomes is called lipofection. 3 Therapeutic Potential Liposomes have potential for treating genetic disorders and diseases.

6. Liposome Applications: Other Uses Cosmetics Liposomes are used to deliver active ingredients to the skin. Food Liposomes can encapsulate nutrients and enzymes for food applications. Textiles Liposomes can deliver dyes to textiles for improved colorfastness.

7. Liposome Discovery 1 1961 Alec Douglas Bangham first described liposomes at the Babraham Institute. 2 1964 Bangham's findings on liposomes were published. 3 1965 The term "liposome" was coined by Gerald Weissmann.

8. Liposome Mechanism: Encapsulation Hydrophilic Molecules Hydrophilic molecules are encapsulated in the aqueous core. Hydrophobic Molecules Hydrophobic molecules are incorporated into the lipid bilayer. Encapsulation Efficiency The amount of encapsulated compound is measured by encapsulation efficiency.

9. Liposome Mechanism: Delivery 1 Fusion Liposomes can fuse with cell membranes, releasing their contents. 2 Endocytosis Cells can engulf liposomes through endocytosis. 3 Diffusion Liposomes can release their contents through diffusion.

10. Liposomes: A Promising Future Liposomes are a versatile and promising technology with applications in various fields. Their ability to encapsulate and deliver molecules makes them valuable tools for drug delivery, gene therapy, and other biomedical applications.