Malaria Life cycle of plasmodium

malaria life cycle

1. PRESENTION ON PRESENTION ON
MALARIA MALARIA
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3. When an female Anophels When an female Anophels
mosquito Penetrates human skin mosquito Penetrates human skin
to obtain a blood meal, it injects to obtain a blood meal, it injects
saliva.saliva.
If the mosquito is infected with If the mosquito is infected with
Plasmodium,it will also inject Plasmodium,it will also inject
elongated Sporozoites into the elongated Sporozoites into the
Blood stream of its victim.Blood stream of its victim.

4. The Sporozoite travel to the The Sporozoite travel to the
Liver where they enter liver Liver where they enter liver
cells & rapidly divide asexually. cells & rapidly divide asexually.
This asexual division , which is This asexual division , which is
called Schizogony,generates called Schizogony,generates
the next life cycle form called the next life cycle form called
Merozoites.Merozoites.
The released Merozoites invade The released Merozoites invade
other liver cells & enter hosts’ other liver cells & enter hosts’
blood stream,where they invade blood stream,where they invade
Erythrocytes.Erythrocytes.

5. Once inside the erythrocytes, the Once inside the erythrocytes, the
Merozoite begins to enlarge as a Merozoite begins to enlarge as a
uninucleate cell termed a ring uninucleate cell termed a ring
trophozoite.The trophphozoite trophozoite.The trophphozoite
nucleus then divides asexually to nucleus then divides asexually to
produce a Schizont which contains produce a Schizont which contains
several nuclei.several nuclei.

The Schizont then divides & The Schizont then divides &
produces mononucleated produces mononucleated
Merozoites.Merozoites.


6. The Erythrocytes ruptures & releases The Erythrocytes ruptures & releases
toxins throughtout the body of host, toxins throughtout the body of host,
bringing about the well known cycle of bringing about the well known cycle of
fever & chills that is characerstics of fever & chills that is characerstics of
Malaria. Malaria.
Plasmodium enters a sexual phase when Plasmodium enters a sexual phase when
some merozoites in the Erythrocytes develop some merozoites in the Erythrocytes develop
into gametocytes, Cells capable of producing into gametocytes, Cells capable of producing
both male & female gamates.Erythrocytes both male & female gamates.Erythrocytes
containing gametocytes do not rupture.containing gametocytes do not rupture.


7. Gametocytes are incapable of producing gamates Gametocytes are incapable of producing gamates
within their human hosts & do so only when they within their human hosts & do so only when they
are extrcted from an infected human host by a are extrcted from an infected human host by a
mosquito.mosquito.
With in the Gut of mosquito, the gametocytes With in the Gut of mosquito, the gametocytes
form male & female gamatesform male & female gamates
The resultant Diploid zygotes develops with in the The resultant Diploid zygotes develops with in the
mosquitoes intestinal walls & ultimatly mosquitoes intestinal walls & ultimatly
differentiatly into oocystdifferentiatly into oocyst

8. Within the oocysts,repeated mitotic Within the oocysts,repeated mitotic
divisions takesplace, producing divisions takesplace, producing
large number of Sporpzoites.large number of Sporpzoites.

These Sporozoites migrate to the These Sporozoites migrate to the
salivary glands of the mosquito & salivary glands of the mosquito &
from they are injected by the from they are injected by the
mosquito into the blood stream of mosquito into the blood stream of
a human,thus starting the life cycle a human,thus starting the life cycle
of parasite again.of parasite again.