Mechanism of action of hormone

Mechanism of hormone action,

1. MECHANISM OF ACTION OF HORMONE Ms.Anu Sebastian: B.Pharm ; M.Pharm Assistant Professor, Dept. Of Pharmacology Nirmala College Of Pharmacy Muvattupuzha,Ernakulam,Kerala

2. MECHANISM OF WATER SOLUBLE HORMONES Secretory cells release water soluble hormones Interstitial fluid Blood plasma Release into target site Bind with G –protein coupled receptor(GPCR) of target site Hormone + GPCR ATP CAMP 2 molecules of cAMP binds with the regulatory sites of Protein Kinase A Dissociation of catalytic site of protein kinase A Phosphorylation of target proteins Produce physiological effect Diffusion Adenyl cyclase

3. MECHANISM OF ACTION OF LIPID SOLUBLE HORMONES Secretory cells release Lipid soluble hormone Interstitial fluid Blood Combines with a carrier protein in blood Reaches target site & diffuse into the target site Enters into cell cytoplasm through plasma membrane Binds with nuclear receptor Gene transcription Translation Protein synthesis Physiological effect

4. Control of Hormone secretion Nervous system Chemical changes in Blood Other hormones Hypothalamus & Pituitary Gland Pituitary gland is also known as the master endocrine gland. Pituitary gland is a pea shaped gland, located in the sphenoid bone & it is attached to the hypothalamus by a stalk known as infundibulum .

5. Pituitary gland is having two lobes: Anterior pituitary (larger) Posterior pituitary (smaller) Anterior pituitary/ Adenohypophysis having two lobes Pars distalis Pars tuberalis Posterior pituitary / Neurohypophysis having two lobes Pars nervosa Infundibulum

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