Mechanism Of Apoptosis, its function and its significance.pptx

explained the mechanism of apoptosis.

1. Topic – Mechanism Of Apoptosis By Ananya khanna Roll No. 18

2. Definition of Apoptosis Apoptosis is defined as a type of cell death that is induced by a tightly regulated suicide program in which cells destined to die activate intrinsic enzymes that degrade the cells’ genomic DNA and nuclear and cytoplasmic proteins.

3. Mechanism of Apoptosis Apoptosis results from the activation of C ASP ASES Presence of active caspases is marker for apoptosis. PRESENCE OF CYSTEINE AT ACTIVE SITE CLEAVE ASPARTATE RESIDUES ENZYMES

4. EXTRINSIC PATHWAY OF APOPTOSIS

5. It is due to engagement of plasma membrane death receptors . Death receptors belong to TNF aplha family like TNFR1. Death domains are present that deliver apoptotic signals. This pathway can be inhibited by FLIP protein that bind to procaspase 8 and inhivit its activation.

6. INTRINSIC PATHWAY OF APOPTOSIS

7. It results from increased permeability of outer mitochondrial membrane with consequent release o f death inducing molecules into cytoplasm. It includes a) Antiapoptotic - BCL2,BCL-X1,MCL1 b) Proapoptotic - BAX and BAK c) Regulated apoptosis inhibitors- BAD,BIM,BID,Puma and Noxa