Merits and Demerits of Glass as a packing materials.pptx

Diksha Kunwar
B.Pharmacy 5th Sem
RR College of Pharmacy, Bangalore
- Merits & Demerits of Glass as packing of a parenterals .

1. 26 -03-2022 © R R INSTITUTIONS , BANGALORE 1 INDUSTRIAL PHARMACY- I MERITS & DEMERITS OF GLASS AS A PACKING MATERIALS FOR PARENTERALS RR COLLEGE OF PHARMACY SUBMITTED BY: SUBMITTED TO: DIKSHA KUNWAR PROF. Dr. A GEETHA LAXMI MAM 5 TH SEM , B.PHARM

2. © R R INSTITUTIONS , BANGALORE 2 Discuss the merits and demerits of glass as a packing materials for Parenterals ? Ans : Parenterals are sterile preparation or sterile dosage form which can be administrated other than the oral route & bypass the metabolism in liver & GI tract, directly goes into systematic circulation.

3. © R R INSTITUTIONS , BANGALORE 3 Different materials are used for packing of Parenterals : Glass Plastic Metals Rubbers Paper & Board

4. © R R INSTITUTIONS , BANGALORE 4 Glass containers: Glass is still preferred material for container for injectables products. Glass container is composed of sand-pure silica , soda ash- NaHCO 3, Lime stone-Calcium Carbonate, Cullet(recycled & Broken glass) that is mixed with batch silicon dioxide.

5. Different Types of Glass: Type I = Borosilicate glass Type II = Treated soda lime glass Type III = Regular soda lime glass Type IV = General purpose sodalime glass © R R INSTITUTIONS , BANGALORE 5

6. Advantages Versatile & attractive: Glass is used in every type of the parentral dosage form mostly it is used in ampoules, vials, saline bottles etc. Different coloured glass are used as packing materials of parenterals and make it attractive. © R R INSTITUTIONS , BANGALORE 6

7. 2. Moulded into different shape, size & colour : Glass used in the parenterals can be easily moulded into different types shapes, size and colour . © R R INSTITUTIONS , BANGALORE 7

8. 3. High Transparency: It has high transparency which allows easy inspection of its content. © R R INSTITUTIONS , BANGALORE 8

9. 4. Protection: Glasses used in the parenterals is coloured to protect the light sensitive materials and to prevent the degradation of API. 5. It is chemically resistance to most of the medicinal product. © R R INSTITUTIONS , BANGALORE 9

10. © R R INSTITUTIONS , BANGALORE 10 6. Sealed: Glasses used in the parenterals can be used to sealed hermetically as a result preventing the passage of air, oxygen and makes its airtight.

11. 7. It is suitable for sterilization at various temperature & pressure. 8. It can be easily recycle & reused and it can be cost effective. 9. They are not deteriorate with age. 10. It is economical & easily available. 11. It can be easily labelled. © R R INSTITUTIONS , BANGALORE 11

12. 12. It is having rigidity & protective quality so that’s why it is used in parenterals preparation. © R R INSTITUTIONS , BANGALORE 12

13. Disadvantages: Fragile: Glass used in parenterals packing are fragile in nature so that it can be easily break by the small force or pressure. Glasses are relatively heavy & difficult to transport. Glasses are harder to decompose. © R R INSTITUTIONS , BANGALORE 13

14. 4. It is expensive to manufacture. 5. During its heat sterilization some type of glass container have the tendency of shedding, some part of the silica into the formulation. 6. Hermetic seal that is more easily compromised. 7. It has vulnerability to fracture from the thermal shock( like rapid temperature changes) & physical shock. © R R INSTITUTIONS , BANGALORE 14

15. References: The theory and practice of industrial pharmacy by Leon Lachmann www.goggle.com http:// en.wikipedia.org/wiki/parenterals © R R INSTITUTIONS , BANGALORE 15

16. © R R INSTITUTIONS , BANGALORE 16