Mesoskinline-Algesium -Silicium for Skin Reconstruction

Mesoskinline is our specially designed concept in anti-ageing treatments - without medical intervention and related risk.
Our concept is based entirely on 100% safe, tested and certified products and equipment from the EU - your guarantee of impressive results

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www.exsymol.com
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. Increases skin cell proliferation
. Stimulates collagen production
. Improves cell communication
. Preserves skin hydration
. Stimulates lipolysis
. Prevents inflammation
. Prevents glycation
. Protects skin cells from free radicals
Detailed scientific files are available on demand for each of these benefits.
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INCI name: METHYLSILANOL MANNURONATE
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Silanols is a family of compounds where all members share
the same core of organic silicium. However, this silicium is
prone to polymerization that will lead to a loss of activity.
It is therefore mandatory to stabilize this organic silicium
core in order to ensure an optimal activity.
The silanol technology relies on exchangeable molecules to
stabilize the organic silicium core and, with each different
molecule chosen to stabilize this core, we have a different,
more specialized silanol.
ALGISIUM is the father of the silanol family. Its organic
silicium core is stabilized with alginic acid that has virtually
no cosmetic benefits. All of
ALGISIUM’s benefits therefore
come from the organic silicium core only.
Active molecule Active molecule
Active molecule
Organic
silicium
core
STABILIZATION
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Si
Cafeine+
CAFEISILANE
For anti-aging benefits coupled
with strong slimming benefits
For anti-aging benefits coupled
with strong soothing benefits
Si Salicylic acid+
D.S.B. C
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Si Hyaluronic acid+
For strong anti-aging benefits in
all skin compartments
EPIDERMOSIL
Because all silanols have the same core of organic silicium, they also have all the benefits it provides. However, depending on which
molecule the silicium core is stabilized with, we can have additional and specific benefits.
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Silicium is an essential component of the skin. Indeed, by
interacting with structure and elastic proteins within the
dermis such as collagen fibers, elastin and proteoglycans, the
silicium insures optimal skin organization and architecture.
Furthermore, many studies show that silicium is capable
of stimulating skin cell metabolism for enhanced cell
proliferation and activity (e.g. collagen production,
contraction ability…).
However, with age the amount of silicium naturally present
in the skin tends to decrease. As a result, an overall
collapse of the skin architecture will happen, which will in
turn induce skin metabolism slow down, inevitably leading
to wrinkles.
With the silanol technology, we replenish the natural pool
of silicium hence allowing a complete skin restructuration
for global benefits at all levels.
Alginic acid Alginic acid
Alginic acid
Organic
silicium
core
SPECIALIZATION
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Wrinkles
Time
Silanol
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. Anti-aging
. Anti-wrinkle
. Eye contour
. Hydration


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. Anti-cellulite
. Slimming
. Firming
. Hydration

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With age, there are more and more adipocytes (fat storing
cells). This causes a fat accumulation leading for example
to cellulite on the body and eye bags on the face.
ALGISIUM stimulates adipocite ability to get rid of the
fat by improving lipolysis. A treatment with ALGISIUM
improves three folds the amount of fat released by
adipocytes. Cellulite is strongly reduced, skin is firmer and
eye bags are reduced.
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Because of aging, keratinocytes have a lower proliferation
rate that slowly leads to an epidermis thinning and eventually
weakens skin protection and reduce skin hydration because
of an increased transepidermis water loss.
ALGISIUM improves the number of proliferative
keratinocytes (in bright green) in human reconstructed
epidermis. That leads to a thickening of the epidermis for
a skin that will be better protected and better hydrated.
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The dermal epidermal junction (DEJ) is the interface between both skin compartments. It is responsible for skin cohesion. With age, the DEJ becomes thinner and can be duplicated, hence leading to a loss of cohesion and a decreased cell communication.
ALGISIUM is capable of improving collagen VII (in green)
expression, one of the key constituent of the DEJ in human
skin explants. This leads to an improved skin cohesion and
skin cell communication.
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With age, all metabolisms tend to slow down. In the dermis this results in a lower proliferation rate and a lower activity
of fibroblasts. There are too few collagen fibers and the skin
is flaccid and wrinkled.
ALGISIUM stimulates fibroblast number and activity.
In the dermis, there will be more fibroblasts and each one
of them will produce more collagen. This strong collagen
booster effect leads to a firmer and more elastic skin.
Wrinkles are filled and erased.
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HYPODERMIS
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Reduced cellulite
Leaner body
DERMIS
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Improved elasticity
Filled wrinkles
EPIDERMIS
Better protection
Better hydration Keratinocyte proliferation
(% of control)
ControlOSC
eq. ALGISIUM
(5%)
130
120
110
100
90
Collagen VII expression
(% of control)
ControlOSC
eq. ALGISIUM
(5%)
130
120
110
100
90
Fat released
(% of control)
Young cells
(10% FCS)
300
200
100
0
ALGISIUM
(3%)
DEJ
Better cohesion
Better cell
communication
+20%
+20%
+163%
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Control Organic silicium core



Control Organic silicium core
Control Organic silicium core

Keratinocytes have the ability to support
fibroblast proliferation by secreting
cytokines that will go from the epidermis
through the DEJ and into the dermis
where fibroblasts are located. With
age, this cross-communication decreases
and keratinocytes lose this ability to
support fibroblast proliferation. That
leads to a generalized impairment of skin
architecture.
ALGISIUM stimulates keratinocyte’s
ability to support fibroblast proliferation
and therefore restores an optimal cell
communication for global benefits.
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Collagen production
(% of control)
Young cells
(10% FCS)
200
100
80
60
40
20
0
Aged cells
(2% FCS)
ALGISIUM
(2.5%)
Aged cells
(3% FCS)
ALGISIUM
(0.01%)
ALGISIUM
(0.1%)
200
150
100
50
0
Fibroblast number
(% of control)
+15%
+96%
+165%
Fibroblast proliferation
(% of control)
Fibroblasts alone
(10% FCS)
200
150
100
50
0
+ aged
keratinocytes
+ ALGISIUM
(1%)
+ ALGISIUM
(1.5%)
+93%
+41%
+60%
Because of aging, the whole skin
architecture is altered, and this is
especially true within the dermis as
the thick dark collagen bundles ( )
observed in a younger skin completely
vanish.
Because of the silicium ability to
stimulate fibroblast combined with its
affinity for collagen fibers, a treatment
with
ALGISIUM leads to a complete
reorganization of skin fibers for strong
and long lasting rejuvenation effect.
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Control
Aged + MTS
Aged + OSC (eq. 4% ALGISIUM)Young Aged
Epidermis
Dermis
Epidermis Epidermis
Dermis Dermis
DEJ
DEJ
DEJ

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Monomethylsilanetriol 0.3%
Including organic SILICIUM 0.09%
Mannuronic acid 0.6%
Water and preservative (sqf) 100%
Limpid and colorless liquid.
S+§
'HQVLW\DWƒ&§
Miscible with water, alcohol and glycol.
Not miscible in oil.
Different preservative systems are available in order to fit with
your requirements. Please contact us for additional details about the
available versions.
ALGISIUM is perfectly tolerated. Tolerance and toxicity studies were
performed using both in vitro (cell culture and reconstructed epidermis)
and in vivo (human volunteers) methods.
Advised doses: 3 to 6%.
ALGISIUM is not temperature sensitive.
Formula pH: 4 to 7.
ALGISIUM is not compatible with high concentrations of calcium salts,
alcohol and glycols.
ALGISIUM is available in 5, 30 kg drums and 1 ton container (IBC).


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Thanks to ALGISIUM’s restructuration properties, global
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of the treatment at 28 days.
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Realized under dermatological control, this test was
performed on 10 women aged 25 to 35. All volunteers
received a treatment with
ALGISIUM (5%) for ten weeks.
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by the end of the treatment.
Ten volunteers aged 28 to 52 received a treatment with
ALGISIUM (6%) and we measured skin hydration only
minutes after a treatment. A dramatic improvement of skin
hydration with a strong long lasting effect was measured.
Before After
Mature skin
(50+)
Deep wrinkles
Adult skin
(40+)
Expression lines
Young skin
(30+)
Skin tone
D14
D28
Improvement (%)
Moisturization
Softness
Luminosity
Radiance
General aspect
30
25
20
15
10
5
0 D14
D28
Placebo
A
LGISIUM (5%)
-3.5
-4.4
-1.7
-0.6
Waist Hip Thigh Knee
0
-1
-2
-3
-4
-5
Cirtometry (cm)
Placebo
A
LGISIUM (6%)
Corneometry unit
100
90
80
70
60
50
0 100 200 300 400
Time (min)
At different age, different problems arise. Thanks to
ALGISIUM’s global benefits, specific problems to all skin
type is treated and solved.
Realized under dermatological control, this test was performed on 35 women aged 32 to 60.
All volunteers received a facial treatment with ALGISIUM (5%) twice a day for 28 days.
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+20% after 2h
+37% after 6h
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5. P8_1457GB1606D
4 avenue Albert II - MC 98000 MONACO
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