Metabolic acidosis

PHYSIOLOGY IN METABOLIC ACIDOSIS HUMAN BODY...

1. Metabolic Acidosis Department of physiology School of medical sciences and research Sharda university sanjog bam HUMAN BIOLOGIST ms c medical physiology

2. INTRODUCTION Disorder characterized by a low arterial pH or a reduced plasma [HCO3-] pH=7.28 and [ HCO3-mEq/L] =18 Most cases of metabolic acidosis results from the abnormal accumulation of organic acids. Uncompensated PCO2 (mm Hg) = 40 & compensated PCO2 = 20mmHg Increased anion gap mostly

3. Common cause LACTIC ACID ACCUMULATION: hypovolemic shock and other forms of circulatory shock :[lactic acidosis] Ketones bodies accumulation: Diabetes mellitus Severe renal failure :kidneys are unable to secrete sufficient H+ to generate new HCO3 - , failure of HCO3 - reabsorbtion Loss of HCO3 - : severe diarrhea, fistula Ingestion of alcohol ,NH 4 Cl,salicylate

4. Respiratory compensation

5. Renal compensation Causes excretion of extra H+ Secreted H+ reacts with buffer system in kidney therefore larger amounts H+ can be secreted ,permitting larger amounts of HCO3 - to be reabsorbed. In chronic acidosis ,kidney gets additional source of NH4+ Respiratory compensation tends to inhibit the renal response but net inhibitory effects is slight.

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