Metabolism of lipoproteins

Synthesis and catabolism of lipoproteins; dyslipoproteinaemia

1. Metabolism of Lipoproteins R. C. Gupta Professor and Head Department of Biochemistry National Institute of Medical Sciences Jaipur, India

2. The apoproteins present in lipoproteins are: Apo A-I Apo A-II Apo B-48 Apo B-100 Apo C-I Apo C-II Apo C-III Apo D Apo E

3. The plasma lipoproteins are classified into: Chylomicrons (CM) Very low density lipoproteins (VLDL) Low density lipoproteins (LDL) High density lipoproteins (HDL)

4. Functions of lipoproteins

5. Metabolism of chylomicrons

6. Metabolism of VLDL

7. Metabolism of LDL

8. Reproduced with permission from Danton O’Day

9. Metabolism of HDL

10. Inherited disorders of lipoprotein metabolism

11. Hypolipoproteinaemia

12. Abetalipoproteinaemia

13. Many patients with abetalipo-proteinaemia die in childhood Those who survive develop: Steatorrhoea Intestinal malabsorption Retinitis pigmentosa Neurological abnormalities

14. Hypobetalipoproteinaemia

15. Hypoalphalipoproteinaemia

16. Hyperlipoproteinaemia

17. In W.H.O. classification, hyperlipo-proteinaemia is divided into six types on the basis of: Fasting plasma levels of CM, VLDL, LDL, HDL, cholesterol and trigly-cerides (after a 14-hour fast) Appearance of serum after standing it for 48 hours (serum storage test)

18. Hyperlipoproteinaemia , type I

19. Hyperlipoproteinaemia , type IIa

20. Hyperlipoproteinaemia , type IIb

21. Hyperlipoproteinaemia , type III

22. Hyperlipoproteinaemia , t ype IV

23. Hyperlipoproteinaemia , t ype V

24. Serum storage test in different types of hyperlipoproteinaemia I IIa IIb III IV V