Methadone, oxazolidinedione.pptx

Methadone and Carbamazepine synthesis is described, Also summarized about oxazolidinedione.

1. Methadone , Carbamazepine and oxazolidinedione By Dr. Nidhi Gupta M.M. University, Mullana , Ambala, India

2. Methadone synthesis Methadone is a chiral substance, therefore, presents itself as a racemic mixture of two enantiomers in mutual relationship of 1:1, respectively the levorotatory form of methadone (L)-methadone and dextrorotary shape (D)-methadone: the dextrorotatory form possesses potent antitussive properties, but is almost completely devoid of analgesic properties; the levorotary one is about two times more effective as an analgesic, than the racemic form of methadone.

3. Methadone synthesis

4. Methadone synthesis contd. The process of chemical synthesis of racemic methadone is obtained from the nitrile with the synthesis of Kolbe and with the diphenylacetonitrile . One can obtain the formation of a racemate L-(+) with the tartaric acid.

5. Oxazolidinedione anticonvulsants Oxazolidinedione  is a  heterocyclic  chemical compound that forms the core structure of a variety  anticonvulsant  drugs including: Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome. Paramethadione

6. 2,4-oxazolidinedione Dimethadione

7. Methyldopa structure Methyldopa