Methods of Asymmetric Synthesis using chiral pool 2.pptx

Detail about Methods of Asymmetric Synthesis using chiral pool including ASYMMETRIC SYNTHESIS,STEREOSELECTIVE SYNTHESIS and ENANTIOPURE SEPERATION

1. Methods of Asymmetric Synthesis using chiral pool PERSENTED TO :- PRESENTED BY:- Dr.Kuldeep Singh Shafiurahman Faculty of P harmacy M. P harm 1 st year Integral University

2. CONTENT Asymmetric synthesis Methods of asymmetric synthesis using chiral pool Chiral auxiliaries and catalytic asymmetric synthesis Enantiopure separation Stereoselective synthesis References

3. ASYMMETRIC SYNTHESIS The direct synthesis of an optically active substance from optically inactive compound with or without the use of optically active reagents is called asymmetric synthesis.

4. LEVOCETIRIZINE DEXTROCETIRIZINE

5. 3.enantioselective catalysts sharless asymmetric epoxidation

6. ENANTIOPURE SEPERATION Enantiopure seperation is a process of seprating isomers in a racemic mixture into their individual enantiomer. 1.Selective crystalisation 2.Supercritical extraction 3.Fractional reaction extraction 4.Diastereomer separation by distillation 5.Membrane assisted seperation 6.Chromatography and simulated moving bed

7. STEREOSELECTIVE SYNTHESIS Stereoselective reactions- reactions where one stereoisomer of products is formed predominantly because the reaction has a choice of pathways,and one pathway is more favourable than the other.

8. The fact that the addition of halogens to alkenes is both stereoselective and stereospecific give us additional information about the stereochemistry of the addition and the mechanism for the reaction.

9. REFERENCES Wikipedia Slide share

10. THANK YOU