micro bioto, METSNew Microsoft Office PowerPoint Presentation (4).pptx

IT EXPLAINS ABOUT THE MICROBIOTA, AND ITS EFFECT IN THE GUT.
IT ALSO SAYS ABOUT THE BENEFITS , ESP IN DIABETIC AND IN METABOLIC SYDROME

1. Microbiome Effect on weight gain., metabolic syndrome.

2. Gut and metabolic syndrome the pathogenesis of MetS is related to a variety of factors, such as insulin resistance, chronic inflammation, autonomic dysfunction, and oxidative stress. In recent years, it has been found that gut microbiota disorder is also a risk factor for the development of MetS

3. certain microbiota -derived metabolites are harmful to the host, which include cytotoxins , genotoxins , and immunotoxins .The gut microbiota , therefore, plays a key role in maintaining the physiological function of the host, and dysbiosis of the gut microbiota caused by various factors leads to extensive physiological changes and increases the risk of MetS .

4. A study found that those who had obesity had different gut bacteria than their twins without obesity. In particular, obesity was associated with lower gut bacteria diversity, meaning there were fewer types of bacteria in the gut . Other studies have shown that if the gut bacteria from people with obesity are put into mice, the mice gain weight. This suggests that gut bacteria could affect weight

5. Studies in mice have found that Akkermansia can reduce weight gain and insulin resistance by reducing inflammation. Similarly, when mice were fed prebiotic fibers to help increase Bifidobacteria in the gut, weight gain and insulin resistance were found to be decreased.

6. body produces a number of different hormones that affect your appetite, including leptin , ghrelin , peptide YY (PYY). Some studies have shown that different bacteria in the gut can affect how much of these hormones are produced and whether you feel hungry or full

7. People who ate 16 grams of prebiotics per day for two weeks had higher levels of hydrogen in their breath. This indicates gut bacterial fermentation, less hunger and higher levels of the hormones GLP-1 and PYY, which make you feel full

8. Lipopolysaccharide endotoxin is the only known bacterial product which, when subcutaneously infused into mice in its purified form, can induce obesity and insulin resistance via an inflammation-mediated pathway.. They showed that one endotoxin -producing bacterium isolated from a morbidly obese human's gut induced obesity and insulin resistance in germfree mice

9. . The Enterobacter -induced obese mice showed increased serum endotoxin load and aggravated inflammatory conditions. The obesity-inducing capacity of this human-derived endotoxin producer in mice suggests that it may contribute to the development of obesity in its human host.

10. . Flax seeds in the diet has been proven to change the growth of gut bacteria and decrease insulin resistance.

11. A recent study found that the ratio of two types of bacteria in your intestines may determine how much weight you lose when given a particular diet. These two bacteria are Prevotella , which digests fiber and carbohydrates, and Bacteroidetes , which people who eat more animal protein and fat have more Prevotella

12. Effect on hunger. Short-chain fatty acids are chemicals that are produced when certain species of gut bacteria break down fiber. One of these is known as propionate. One study in 60 overweight adults found that taking propionate for 24 weeks significantly increased levels of the hormones PYY and GLP-1, both of which influence hunger. People who took propionate also had reduced food intake and reduced weight gain

13. THANK YOU

14. “The concept that gut bacteria contribute not only to atherosclerosis , but also to heart failure and chronic kidney disease, opens up exciting new nutritional and interventional prospects,” says Stanley Hazen, MD, PhD , Head of Preventive Cardiology and Rehabilitation.