Microphtalmosvsnanophthalmosclinical .pptx

Clinical diferencias del microftalmos

1. Kouatzin Aguilar Morales Microphtalmos VS Nanoftalmos

2. Anatomical calcification of short eyes Carricondo PC, Andrade T, Prasov L, Ayres BM, Moroi SE. Nanophthalmos : A Review of the Clinical Spectrum and Genetics . J Ophthalmol . 2018 May 9;2018:2735465. doi : 10.1155/2018/2735465. PMID: 29862063; PMCID: PMC5971257.

3. Anophthalmia Absence of the eye Simple microphthalmos Short axial length due to global eye reduction with no other findings Complex microphthalmos Short axial length due to global eye reduction and associated ocular malformations (e.g., colobomas, persistent fetal vasculature, retinal dysplasia) Relative anterior microphthalmos Short axial length due to reduced anterior chamber dimension only, with normal posterior segment dimension and normal scleral thickness Posterior microphthalmos Short axial length due to reduced posterior segment dimension with normal anterior chamber dimensions Nanophthalmos Short axial length due to small anterior and posterior segments with thickened choroid and sclera and normal lens volume The clinical spectrum of the small eye phenotype.

4. Duke-Elder in 1964 described 3 categories… Simple microphtalmos ( nanophtalmos ) Short eye no morphologyc anomalies Colobomatous microphtalmos Incomplete closure of embryonic fissure Complex microphtalmos Systemic animalities and other anomalies of the eye Cataract Surgery, 3rd Edition PART V – Special Techniques for Cataract Extraction Chapter 33 – Nanophthalmos , Relative Anterior Microphthalmos, and Axial Hyperopia

5. Nanophthalmos (Simple Microphthalmos) Axial length ( reduction of 2 standard deviations) < 20.5 mm No systemic or other ocular morphologic abnormalities Atosomal Recessive chromosome 11 five genes (i.e., MFRP, TMEM98, PRSS56, BEST1, and CRB1) and two loci have been implicated in familial forms of nanophthalmos . Poor visual acuity related to a high refractive error Wu et al. considered shallow anterior chamber, high hyperopia, axial length up to 21 mm, and posterior wall thickness greater than 1.7 mm as conditions to define nanophthalmic eyes Cataract Surgery, 3rd Edition PART V – Special Techniques for Cataract Extraction Chapter 33 – Nanophthalmos , Relative Anterior Microphthalmos, and Axial Hyperopia

6. Clinical features of nanophtalmos Cataract Surgery, 3rd Edition PART V – Special Techniques for Cataract Extraction Chapter 33 – Nanophthalmos , Relative Anterior Microphthalmos, and Axial Hyperopia

7. Collagen fibers Variations in the size of collagen fibers [23,][27,][28] Increased fraying and splitting of collagen fibers [23] Disordered lamellar arrangement of collagen bundles [22,][29] Extracellular matrix Glycosaminoglycan deposits [22–24] Increased fibronectin content [28]

8. Clinical spectrum of eye size phenotypes based on axial length and anterior segment features by anterior chamber depth and white-to-white corneal diameter  Axial length ( reduction of 2 standard deviations) < 21.00 adults <19.00 in 1 year old child Carricondo PC, Andrade T, Prasov L, Ayres BM, Moroi SE. Nanophthalmos : A Review of the Clinical Spectrum and Genetics . J Ophthalmol . 2018 May 9;2018:2735465. doi : 10.1155/2018/2735465. PMID: 29862063; PMCID: PMC5971257.

9. Carricondo PC, Andrade T, Prasov L, Ayres BM, Moroi SE. Nanophthalmos : A Review of the Clinical Spectrum and Genetics . J Ophthalmol . 2018 May 9;2018:2735465. doi : 10.1155/2018/2735465. PMID: 29862063; PMCID: PMC5971257.

10. Microphtalmos

11. Cataract Surgery, 3rd Edition PART V – Special Techniques for Cataract Extraction Chapter 33 – Nanophthalmos , Relative Anterior Microphthalmos, and Axial Hyperopia

12. Colobomatous microphtalmos Involution of the primary optic disc or incomplete closure of the embryonic fissure Inferonasally Iris or choroidal coloboma, orbital cysts The visual pathways and the occipital cortex may also be hypoplasic. Cataract Surgery, 3rd Edition PART V – Special Techniques for Cataract Extraction Chapter 33 – Nanophthalmos , Relative Anterior Microphthalmos, and Axial Hyperopia

13. Complex microphtalmos Cataract Surgery, 3rd Edition PART V – Special Techniques for Cataract Extraction Chapter 33 – Nanophthalmos , Relative Anterior Microphthalmos, and Axial Hyperopia

14. Relative anterior microphtalmos Anatomic parameters in relative anterior microphthalmos vs. nanophthalmos Cataract Surgery, 3rd Edition PART V – Special Techniques for Cataract Extraction Chapter 33 – Nanophthalmos , Relative Anterior Microphthalmos, and Axial Hyperopia

15. Axial high hyperopia Cataract Surgery, 3rd Edition PART V – Special Techniques for Cataract Extraction Chapter 33 – Nanophthalmos , Relative Anterior Microphthalmos, and Axial Hyperopia

16. Idiopatic and inhereted isolated microphtalmos