MULTI DRUG RESISTANCE _TB_Presentation.pptx

MDR TB Presentations

1. Prevalence of Multidrug Resistance Tuberculosis in Adult Patients in India: A Systematic Review and Meta-Analysis Authors: Jaykaran Charan, Nitish Tank, Tea Reljic, Surjit Singh, Pankaj Bhardwaj, Rimplejeet Kaur, Jagdish P. Goyal, Ambuj Kumar Journal: Journal of Family Medicine and Primary Care (2019)

2. Abstract Background: MDR-TB is a critical public health issue in India. However, national-level prevalence data are limited. Methods: A systematic review and meta-analysis were conducted using observational studies from PubMed and Google Scholar. Results: - MDR-TB prevalence in new cases: 3% (95% CI: 2%-5%) - MDR-TB prevalence in previously treated cases: 35% (95% CI: 29%-41%) Conclusion: The study found higher MDR-TB prevalence in previously treated cases compared to national survey estimates.

3. Introduction • Tuberculosis (TB): Leading infectious cause of death worldwide. • MDR-TB: Resistant to first-line drugs (rifampicin and isoniazid). • India: Accounts for one-fourth of the global TB burden. • Challenges: - Limited diagnostic facilities in low-income settings. - Poor treatment adherence leading to drug resistance.

4. Objectives • To determine the prevalence of MDR-TB in adult patients in India. • To compare newly diagnosed vs. previously treated TB cases. • To analyze regional variations and methodological differences in MDR-TB prevalence studies.

5. Materials & Methods • Study Design: Systematic review and meta-analysis. • Data Sources: PubMed and Google Scholar. • Selection Criteria: - Included: Observational studies reporting MDR-TB prevalence in India. - Excluded: Review articles, duplicate studies, and non-English papers.