Multiple Dosage Regimen.pptx

Welcome to my SlideShare presentation on Multiple Dosage Regimens. In this comprehensive guide, we delve into the intricacies of creating and understanding multiple dosage regimens.

1. Multiple Dosage Regimen(MDR)

2. CONTENTS 01 Main concept of MDR 02 Steady-state plasma concentration 03 Drug Accumulation

3. Multiple dosage regimen: To maintain prolonged therapeutic action some drugs are given in multiple-dose. The objective of the dosage regimen: The overall objective of dosage regimen design is to achieve a target drug concentration at the receptor site.

4. Multiple dosage regimen:

5. Why multiple dosages regimen is important? Ensure the correct dose To achieve an optimum therapeutic effect Prevent drug accumulation besides the therapeutic level For better action

6. The most important factor affecting the design of the dosage regimen: The size of the drug dose The frequency of drug administration, tau( tau sign means the time interval) Multiple dosage regimen:

7. The concentration at which the drug concentration consistently stays is known as the steady concentration. Note: At all steady-state levels the rate of change in drug concentration is zero. Steady state plasma concentration( Css /Cav infinity )

8. Drug Accumulation Deposition of the drug in the body. Cmax is an important parameter to understand drug accumulation. When the value of Cmax infinity crosses the MTC level then there is drug accumulation occurs. time Plasma concentration

9. So it’s a question for you Why does this type of deposition occur in our body?

10. The mathematical expression of drug accumulation R=1 R<1; no accumulation occur R>1; in case of loading dose Expected: R=1 MTC level MEC level Time Plasma concentration

11. Note: This equation mainly depends on- Elimination rate constant/ Elimination half-life 2. Frequency/Dosing interval Equation of accumulation half-life

12. Accumulation half-life The time taken to achieve half of the steady-state concentration is the accumulation half-life. The equation derived by Van Rossum and Tomey - Accumulation half-life depends on the elimination half-life and route of administration.

13. THANK YOU

14. Any Query?