Non selective beta blockers

Beta Blockers

1. NON SELECTIVE BETA-BLOCKERS BY SHIVA HOSUR

2. WHAT ARE BETA BLOCKERS ?? BETA BLOCKERS ARE THE DRUGS THAT BLOCK THE ACTION OF CATECHOLAMINES MEDIATED THROUGH β RECEPTORS ALL β BLOCKERS ARE COMPETATIVE ANTAGONISTS

3. CLASSIFICATION

4. PHARMACOLOGICAL ACTIONS HEART – beta blockers decreases HR, FORCE OF CONTRACTION, CARDIAC OUTPUT BP FALLS AV CONDUCTION IS DELAYED DUE TO BLOCKADE OF BETA RECEPORS IN AV NODE ,THUS MYOCARDIAL OXYGEN REQUIREMENT IS REDUCED DUE TO REDUCED CARDIAC WORK. BETA-BLOCKERS PREVENTS EXERCISE –INDUCED IN HR & FORCE OF CONTRACTION

5. PHARMACOLOGICAL ACTION RESPIRATORY TRACT- BLOCKADE OF β 2 RECEPTORS IN BRONCHIAL SMOOTH MUSCLE CAUSES AN INCREASES IN AIRWAY RESISTANCE MAY PRECIPITATE ACCUTE ATTACK IN ASTHMATICS. EYE- MANY BETA BLOCKERS REDUCES IOP BY DECREASED SECRETION OF AQUEOUS HUMOUR OTHER EFFECTS- MANY BETA BLOCKERS IN HIGHER DOSES SODIUM CHANNELS AND HAVE A LOCAL ANAESTHETIC EFFECT- MEMBRANE STABLISING EFFECT

6. NON SELECIVE BETA BLOCKERS SOTALOL - NON SELECTIVE ,HAS ADDITIONAL POTASSIUM CHANNEL BLOCKING PROPERTY . NADOLOL - LONG ACTING BETA BLOCKER ,USED IN HYPERTENSION,ANGINA ,OESOPHAGEAL VARICES, MIGRANE PROPHYLAXIS AND IN TREMORS.

7. BETA BLOCKER IN EYE

8. PINDOLOL OXPRENOLOL & PENBUTALOL NON SELECTIVE, PARTIAL AGONISTS ACT BETA 1 & BETA 2 RECEPTORS . PENBUTOLOL IN ADDITION HAS WEAK INTRINSIC SYMPATHOMIMETIC ACTIVITY. ADVANTAGES MILDER BRADYCARDIA MILDER MYOCARDIAL DEPRESSION BETTER TOLERATED IN ASTHMATICS MILDER EFFECT ON LIPID PROFILE LESS CHANCES OF REBOUND HYPERTENSION ON WITHDRAWAL.

9. DIS ADVANTAGE NOT SUITABLE FOR PROPHYLAXIS OF MIGRANE AND MYOCARDIAL INFARCTION DOSES PINDOLOL-10-30 mg OXPRENOLOL -40-80mg PENBUTALOL-20-80mg LEVATOL 20,40mg

10. ADVANTAGES OF CARDIO SELECTIVE β BLOCKERS OVER NON SELECTIVE β BLOCKERS SAFER IN ASTHMATICS SAFER IN DIABETES PERIPHERAL VASCULAR DISEASES LESS DELETERIOUS EFFECTS ON LIPID PROFILE LESS LIABLE TO IMPAIR EXERCISE CAPACITY

11. Third generation beta blockers THESE INCLUDES ,CARVEDILOL,CARTELOL,LAVETALOL,BUCINDALOL THESE ARE BETA BLOCKERS WITH ADDITIONAL VASODIALATORY PROPERTIES CARTELOL- NON SELECTIVE BETA BLOCKER WITH PARTIAL AGONISTIC ACTIVITY AT β 1 RECEPTORS AND THUS CAUSES BRADYCARDIA CARVEDILOL- BLOCKS β 1, β 2 & α 1 RECEPTORS IT ALSO HAS MEMBRANE STABILIZING AND ANTI INFLAMMATORY PROPERTIES.